公开(公告)号：WO2011024031A1

公开(公告)日：2011-03-03

申请号：PCT/IB2009/053779

申请日：2009-08-29

Applicant: FORIMTECH S.A. ,  GRIGORIEV, Eugene

Inventor： GRIGORIEV, Eugene

IPC: G01T1/161

CPC classification number: G01T1/161 ,  A61B6/4258

Abstract: A simple and potentially disposable compact probe of Figure 1, which is primarily aimed to be used for radio-guided or fluorescence-guided surgery, diagnostics or biopsy, and method of using it, is invented. The novel method reduces limitations inherent to the existing technologies. It consists in shifting most of the functions (signal analysis, detector controls and user visual and audio interfaces) from the probe to an external personal computer connected with the probe via wireless link. Maximum simplification and miniaturization of the probe itself makes it potentially disposable, supplied in sterile package similar to disposable syringe. Due to use of single photon time-resolved counting photo-sensors and microelectronic circuits with sub-nanosecond timing, the probe can be used with fluorescent markers as well. New probe should enhance efficiency of medical procedures and open opportunities for more wide application of the intra-operative probing techniques in medical practice, especially in oncology. Applications other than medical are also possible.

Abstract translation: 发明了一种主要旨在用于无线电导引或荧光引导手术，诊断或活检的简单且潜在的一次性紧凑型探针及其使用方法。 新颖的方法减少了现有技术固有的局限性。 它将大多数功能（信号分析，检测器控制和用户视觉和音频接口）从探头转移到通过无线链路与探头连接的外部个人计算机。 探头本身的最大化简化和小型化使其成为潜在的一次性，在无菌包装中提供，类似于一次性注射器。 由于使用具有亚纳秒时间的单光子时分解算光电传感器和微电子电路，探针也可与荧光标记一起使用。 新的探索应该提高医疗程序的效率，并开放更广泛地应用于医学实践中的术中探查技术的机会，特别是肿瘤学。 医疗以外的应用也是可以的。

公开(公告)号：WO2007131536A1

公开(公告)日：2007-11-22

申请号：PCT/EP2006/005828

申请日：2006-05-11

Applicant: ADVANCED ACCELERATOR APPLICATIONS ,  FORIMTECH S.A. ,  BUONO, Stefano ,  DESFORGES, Iris ,  GRIGORIEV, Eugène ,  ROCCA, Roberto

Inventor： BUONO, Stefano ,  DESFORGES, Iris ,  GRIGORIEV, Eugène ,  ROCCA, Roberto

IPC: G01T5/08 ,  G01T1/161

CPC classification number: G01T1/161 ,  A61B6/4258 ,  A61B6/508 ,  G01T1/201

Abstract: The invention relates to detection of radiations by means of any appropriate devices, particularly those comprising small probes used e.g. in diagnostics or in surgery., or in biomedical or pharmacological research. The aim of the invention is to improve the performance of probes and their working methods in terms i.a of background, miniaturization sensitivity and selectivity. In this respect, the invention concerns a Method of detecting, locating and/or analyzing a radioactive source(s) emitting charged or neutral particles in a material, particularly a biological tissue, consisting essentially in using scintillating fiber(s) having a ratio L (Length) / r (range of the particles emitted by the source) ≥ 2, d (diameter) / r ≤ 5, and L / d ≥ 2; scanning the surface of the material with the detection rod; collecting by means of a SiPM, the scintillation light output (SL ο ) generated by the particles having entered and interacted with the scintillating fiber(s) and emitted at the outlet end; optionally selecting signals SL ο corresponding essentially to the particles entering the scintillating fiber(s) in a substantially axial direction (directional sensitivity), that is to say eliminating the particles which angle α p , that is the angle between the axis of the scintillating fiber and the direction of the particles entering the scintillating fiber, is greater than αt (α p > α t ), then which length lp is lower than l t (1 t ), correlating SL ο, and optionally the selected signals, to the presence of a source of radiation located in the mass of the material to be analyzed; and optionally communicating these data to the user. Applications: onco-diagnostics, pre- or intra-operative (onco) surgery, neurosurgery, cardiosurgery and diagnostics, bio-medical and pharmaceutical research.

Abstract translation: 本发明涉及通过任何合适的装置检测辐射，特别是包括例如使用的小探针的装置。 诊断或手术，或生物医学或药物研究。 本发明的目的是提高探针的性能和它们的工作方法，其依据是背景的i.a，小型化灵敏度和选择性。 在这方面，本发明涉及一种检测，定位和/或分析在材料，特别是生物组织中发射带电或中性粒子的放射源的方法，该材料基本上使用具有比率L的闪烁纤维 （长度）/ r（由源发射的粒子的范围）= 2，d（直径）/ r = 5，L / d = 2; 用检测杆扫描材料的​​表面; 通过SiPM收集由已经进入并与闪烁纤维相互作用并在出口端发射的颗粒产生的闪烁光输出（SL < 可选地基本上选择基本上与进入闪烁光纤的颗粒基本上轴向方向（方向灵敏度）相对应的信号SL 1，这就是说，消除角度θ< SUB>，即闪烁纤维的轴线和进入闪烁纤维的颗粒的方向之间的角度大于在（a / b） ，那么哪个长度lp低于1（1 t），将SL SUB和可选的所选信号相关联到 位于待分析材料质量中的辐射源的存在; 并且可选地将这些数据传送给用户。 应用：诊断，手术前或手术（onco）手术，神经外科，心脏手术和诊断，生物医学和药物研究。

公开(公告)号：EP2470926A1

公开(公告)日：2012-07-04

申请号：EP09764578.2

申请日：2009-08-29

Applicant: Forimtech S.A.

Inventor： GRIGORIEV, Eugene

IPC: G01T1/161

CPC classification number: G01T1/161 ,  A61B6/4258

Abstract: A simple and potentially disposable compact probe of Figure 1, which is primarily aimed to be used for radio-guided or fluorescence-guided surgery, diagnostics or biopsy, and method of using it, is invented. The novel method reduces limitations inherent to the existing technologies. It consists in shifting most of the functions (signal analysis, detector controls and user visual and audio interfaces) from the probe to an external personal computer connected with the probe via wireless link. Maximum simplification and miniaturization of the probe itself makes it potentially disposable, supplied in sterile package similar to disposable syringe. Due to use of single photon time-resolved counting photo-sensors and microelectronic circuits with sub-nanosecond timing, the probe can be used with fluorescent markers as well. New probe should enhance efficiency of medical procedures and open opportunities for more wide application of the intra-operative probing techniques in medical practice, especially in oncology. Applications other than medical are also possible.