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    SPECIFIC DELIVERY OF DRUGS TO THE BRAIN
    3.
    发明申请
    SPECIFIC DELIVERY OF DRUGS TO THE BRAIN 审中-公开

    公开(公告)号：WO2004112747A3

    公开(公告)日：2004-12-29

    申请号：PCT/US2004/018850

    申请日：2004-06-15

    Applicant: BAXTER INTERNATIONAL INC. ,  RABINOW, Barrett, E. ,  GENDELMAN, Howard, E. ,  KIPP, James, E.

    Inventor： RABINOW, Barrett, E. ,  GENDELMAN, Howard, E. ,  KIPP, James, E.

    IPC: A61K9/14

    Abstract: The present invention is concerned with delivering a pharmaceutical composition to the brain of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the brain of a portion of the pharmaceutical composition by cells capable of reaching the brain. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytised or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the brain.

    METHOD FOR DELIVERING DRUGS TO THE BRAIN
    4.
    发明申请
    METHOD FOR DELIVERING DRUGS TO THE BRAIN 审中-公开
    将药物递送至脑的方法

    公开(公告)号：WO2004112747A2

    公开(公告)日：2004-12-29

    申请号：PCT/US2004/018850

    申请日：2004-06-15

    Applicant: BAXTER INTERNATIONAL INC. ,  RABINOW, Barrett, E. ,  GENDELMAN, Howard, E. ,  KIPP, James, E.

    Inventor： RABINOW, Barrett, E. ,  GENDELMAN, Howard, E. ,  KIPP, James, E.

    IPC: A61K9/00

    CPC classification number: A61K9/00 ,  A61K9/0085 ,  A61K9/5123 ,  A61K9/5146 ,  A61K47/6901

    Abstract: The present invention is concerned with delivering a pharmaceutical composition to the brain of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the brain of a portion of the pharmaceutical composition by cells capable of reaching the brain. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytised or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the brain.

    Abstract translation: 本发明涉及向哺乳动物受试者的脑中递送药物组合物以治疗脑部疾病或病症。 该方法包括以下步骤：（i）提供药物组合物的分散体作为平均粒度为约150nm至约100微米的颗粒，和（ii）向哺乳动物受试者施用分散体以递送至脑 的药物组合物的一部分能够到达脑的细胞。 例如，作为颗粒的药物组合物的分散体可以在给予哺乳动物受试者之前或之后被细胞吞噬或吸附。 药物组合物的分散体可以施用于中枢神经系统或血管系统。 给药后，负载的细胞将药物组合物作为颗粒输送到脑中。

    METHOD FOR DELIVERING PARTICULATE DRUGS TO TISSUES
    6.
    发明申请
    METHOD FOR DELIVERING PARTICULATE DRUGS TO TISSUES 审中-公开
    将颗粒药物递送给组织的方法

    公开(公告)号：WO2007124224A3

    公开(公告)日：2008-04-17

    申请号：PCT/US2007064679

    申请日：2007-03-22

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  RABINOW BARRETT E ,  GENDELMAN HOWARD E ,  KIPP JAMES E

    Inventor： RABINOW BARRETT E ,  GENDELMAN HOWARD E ,  KIPP JAMES E

    IPC: A61K9/10 ,  A61K9/00 ,  A61K9/51 ,  A61K47/48 ,  A61P31/18

    CPC classification number: A61K9/0085 ,  A61K9/10 ,  A61K9/5123 ,  A61K9/5146 ,  A61K47/6901

    Abstract: The present invention is concerned with delivering a pharmaceutical composition to a tissue target of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the tissue target of a portion of the pharmaceutical composition by cells capable of reaching the tissue target. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytised or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the tissue target.

    Abstract translation: 本发明涉及将药物组合物递送至哺乳动物受试者的组织靶以治疗脑部疾病或病症。 该方法包括以下步骤：（i）提供药物组合物的分散体作为平均粒度为约150nm至约100微米的颗粒，和（ii）向哺乳动物受试者施用分散体以递送至组织 通过能够到达组织靶的细胞的一部分药物组合物的靶标。 例如，作为颗粒的药物组合物的分散体可以在给予哺乳动物受试者之前或之后被细胞吞噬或吸附。 药物组合物的分散体可以施用于中枢神经系统或血管系统。 给药后，负载的细胞将药物组合物作为颗粒输送到组织靶中。

    METHOD FOR DELIVERING PARTICULATE DRUGS TO TISSUES
    8.
    发明申请
    METHOD FOR DELIVERING PARTICULATE DRUGS TO TISSUES 审中-公开
    将颗粒药物递送给组织的方法

    公开(公告)号：WO2007124224A2

    公开(公告)日：2007-11-01

    申请号：PCT/US2007/064679

    申请日：2007-03-22

    Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  RABINOW, Barrett, E. ,  GENDELMAN, Howard, E. ,  KIPP, James, E.

    Inventor： RABINOW, Barrett, E. ,  GENDELMAN, Howard, E. ,  KIPP, James, E.

    IPC: A61K9/00 ,  A61K9/51 ,  A61K47/48

    CPC classification number: A61K9/0085 ,  A61K9/10 ,  A61K9/5123 ,  A61K9/5146 ,  A61K47/6901

    Abstract: The present invention is concerned with delivering a pharmaceutical composition to a tissue target of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the tissue target of a portion of the pharmaceutical composition by cells capable of reaching the tissue target. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytised or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the tissue target.

    Abstract translation: 本发明涉及将药物组合物递送至哺乳动物受试者的组织靶以治疗脑部疾病或病症。 该方法包括以下步骤：（i）提供药物组合物的分散体作为平均粒度为约150nm至约100微米的颗粒，和（ii）向哺乳动物受试者施用分散体以递送至组织 通过能够到达组织靶的细胞的一部分药物组合物的靶标。 例如，作为颗粒的药物组合物的分散体可以在给予哺乳动物受试者之前或之后被细胞吞噬或吸附。 药物组合物的分散体可以施用于中枢神经系统或血管系统。 给药后，负载的细胞将药物组合物作为颗粒输送到组织靶中。

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