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    SINGLE RECEPTOR ASSAYS FOR IMMUNOSUPPRESSIVE DRUGS
    3.
    发明申请
    SINGLE RECEPTOR ASSAYS FOR IMMUNOSUPPRESSIVE DRUGS 审中-公开
    用于免疫抑制药物的单独受体测定法

    公开(公告)号：WO2007028580A3

    公开(公告)日：2007-05-10

    申请号：PCT/EP2006008664

    申请日：2006-09-06

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  SIGLER GERALD ,  GHOSHAL MITALI ,  DORN ALLAN ,  RASHID SHAKER

    Inventor： SIGLER GERALD ,  GHOSHAL MITALI ,  DORN ALLAN ,  RASHID SHAKER

    IPC: G01N33/94 ,  C12Q1/533

    CPC classification number: G01N33/9493 ,  G01N21/6445 ,  G01N21/76 ,  G01N33/5308 ,  G01N33/54346 ,  G01N2021/6432

    Abstract: A highly specific homogeneous assay method for an immunosuppressive drug using an immunophilin in a single receptor format is provided. In the simplest format, a single receptor is utilized analogous to a competitive immunoassay whereby an immunophilin is substituted for an antibody, and a competition results between a drug conjugate and the drug analyte for a limited number of immunophilin binding sites. In a microparticle agglutination assay format, an immunophilin is either bound to a particle or in solution. In the case where an immunophilin is bound to a particle, a polyvalent conjugate of the drug analyte is present in solution.

    Abstract translation: 提供了使用单亲受体形式的免疫亲和素的免疫抑制药物的高度特异性均质测定方法。 在最简单的格式中，利用类似于竞争性免疫测定法的单一受体，其中亲免蛋白取代抗体，并且药物缀合物和药物分析物之间的竞争结果针对有限数量的亲免素结合位点。 在微粒凝集测定形式中，免疫亲和素与粒子或溶液结合。 在免疫亲和素与颗粒结合的情况下，药物分析物的多价缀合物存在于溶液中。

    SINGLE RECEPTOR ASSAYS FOR IMMUNOSUPPRESSIVE DRUGS
    4.
    发明申请
    SINGLE RECEPTOR ASSAYS FOR IMMUNOSUPPRESSIVE DRUGS 审中-公开
    用于免疫抑制药物的单次受体测定

    公开(公告)号：WO2007028580A2

    公开(公告)日：2007-03-15

    申请号：PCT/EP2006/008664

    申请日：2006-09-06

    Applicant: ROCHE DIAGNOSTICS GMBH ,  F. HOFFMANN-LA ROCHE AG ,  SIGLER, Gerald ,  GHOSHAL, Mitali ,  DORN, Allan ,  RASHID, Shaker

    Inventor： SIGLER, Gerald ,  GHOSHAL, Mitali ,  DORN, Allan ,  RASHID, Shaker

    IPC: G01N33/94 ,  C12Q1/533

    CPC classification number: G01N33/9493 ,  G01N21/6445 ,  G01N21/76 ,  G01N33/5308 ,  G01N33/54346 ,  G01N2021/6432

    Abstract: A highly specific homogeneous assay method for an immunosuppressive drug using an immunophilin in a single receptor format is provided. In the simplest format, a single receptor is utilized analogous to a competitive immunoassay whereby an immunophilin is substituted for an antibody, and a competition results between a drug conjugate and the drug analyte for a limited number of immunophilin binding sites. In a microparticle agglutination assay format, an immunophilin is either bound to a particle or in solution. In the case where an immunophilin is bound to a particle, a polyvalent conjugate of the drug analyte is present in solution.

    Abstract translation: 提供了使用单一受体形式的免疫亲和素的免疫抑制药物的高度特异性均一测定方法。 以最简单的形式，使用类似于竞争性免疫测定法的单一受体，其中免疫亲和素取代抗体，并且在有限数量的免疫亲和素结合位点之间的药物缀合物和药物分析物之间产生竞争。 在微粒凝集测定形式中，免疫亲和素结合于颗粒或溶液中。 在免疫亲和素与颗粒结合的情况下，溶液中存在药物分析物的多价缀合物。

    INDINAVIR DERIVATIVES USEFUL IN IMMUNOASSAY
    5.
    发明申请
    INDINAVIR DERIVATIVES USEFUL IN IMMUNOASSAY 审中-公开
    INDINAVIR衍生物有用于免疫

    公开(公告)号：WO2006050964A3

    公开(公告)日：2006-10-19

    申请号：PCT/EP2005012085

    申请日：2005-11-11

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  GHOSHAL MITALI ,  SIGLER GERALD ,  PATWARDHAN ANIRUDDHA P

    Inventor： GHOSHAL MITALI ,  SIGLER GERALD ,  PATWARDHAN ANIRUDDHA P

    IPC: C07D241/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/12 ,  C07K16/36 ,  C07K16/38 ,  C07K16/44 ,  G01N33/53

    CPC classification number: C07K16/38 ,  C07D241/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/12 ,  C07K16/44 ,  G01N33/94

    Abstract: Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the indane ring hydroxyl group or the pyridine ring nitrogen of indinavir. Also disclosed is synthesis of a major metabolite of indinavir (M6) in a single step from indinavir using palladium catalyst and hydrogen gas. Indinavir M6 has been extended to synthesize various analogs of indinavir with suitable functional groups. These derivatives are useful in the development of indinavir immunogens, antibodies, and labeled conjugates in the development of indinavir immunoassays.

    Abstract translation: 用于产生抗体的茚地那韦的衍生物和缀合物和用于检测生物样品中茚地那韦的标记的缀合物。 衍生物由茚满环羟基或茚地那韦的吡啶环氮合成。 还公开了使用钯催化剂和氢气从茚地那韦单一步骤合成茚地那韦（M6）的主要代谢物。 茚地那韦M6已被扩展，以合成具有合适官能团的茚地那韦的各种类似物。 这些衍生物可用于开发茚地那韦免疫测定中的茚地那韦免疫原，抗体和标记的缀合物。

    INDINAVIR DERIVATIVES USEFUL IN IMMUNOASSAY
    6.
    发明申请
    INDINAVIR DERIVATIVES USEFUL IN IMMUNOASSAY 审中-公开
    INDINAVIR衍生物可用于免疫检测

    公开(公告)号：WO2006050964A2

    公开(公告)日：2006-05-18

    申请号：PCT/EP2005/012085

    申请日：2005-11-11

    Applicant: ROCHE DIAGNOSTICS GMBH ,  F-HOFFMANN-LA ROCHE AG ,  GHOSHAL, Mitali ,  SIGLER, Gerald ,  PATWARDHAN, Aniruddha, P.

    Inventor： GHOSHAL, Mitali ,  SIGLER, Gerald ,  PATWARDHAN, Aniruddha, P.

    IPC: C07D241/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/12 ,  C07K16/36 ,  G01N33/53

    CPC classification number: C07K16/38 ,  C07D241/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/12 ,  C07K16/44 ,  G01N33/94

    Abstract: Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the indane ring hydroxyl group or the pyridine ring nitrogen of indinavir. Also disclosed is synthesis of a major metabolite of indinavir (M6) in a single step from indinavir using palladium catalyst and hydrogen gas. Indinavir M6 has been extended to synthesize various analogs of indinavir with suitable functional groups. These derivatives are useful in the development of indinavir immunogens, antibodies, and labeled conjugates in the development of indinavir immunoassays.

    Abstract translation: 用于产生抗体的茚地那韦衍生物和缀合物以及用于检测生物样品中茚地那韦的标记缀合物。 衍生物由茚满环的羟基或茚地那韦的吡啶环氮合成。 还公开了使用钯催化剂和氢气从茚地那韦一步合成茚地那韦主要代谢产物（M6）。 茚地那韦M6已扩展为合成具有合适官能团的各种茚地那韦类似物。 这些衍生物在开发茚地那韦免疫测定法中用于开发茚地那韦免疫原，抗体和标记的偶联物是有用的。

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