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公开(公告)号：WO2006116362A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/015566
申请日：2006-04-25
Applicant: THE TRUSTEES OF BOSTON UNIVERSITY , UNLU, Selim, M. , BERGSTEIN, David, A. , RUANE, Michael, F. , GOLDBERG, Bennett, B.
Inventor： UNLU, Selim, M. , BERGSTEIN, David, A. , RUANE, Michael, F. , GOLDBERG, Bennett, B.
IPC: G02B5/00
CPC classification number: G01N21/77 , B01J2219/00378 , B01J2219/00387 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , G01N21/45 , G01N21/75 , G01N33/54373 , G01N2021/7779 , G01N2201/061 , G02B21/34 , C12Q2565/619
Abstract: This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., DNA, RNA, and protein) using standard SiO 2 -based microarray technology.
Abstract translation: 本公开提供了用于无标记检测目的靶分子的方法和装置。 本公开的原理特别适用于使用标准SiO 2基微阵列技术检测生物分子（例如DNA，RNA和蛋白质）。
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公开(公告)号：WO2004083820A9
公开(公告)日：2004-11-11
申请号：PCT/US2004008558
申请日：2004-03-19
Applicant: UNIV BOSTON , UNLU SELIM M , BERGSTEIN DAVID A , RUANE MICHAEL F , GOLDBERG BENNETT B
Inventor： UNLU SELIM M , BERGSTEIN DAVID A , RUANE MICHAEL F , GOLDBERG BENNETT B
IPC: G01N20060101 , G01N21/64 , G01N
CPC classification number: G01N21/7746 , B01L3/5027 , G01N21/0303 , G01N21/253
Abstract: An assay system having a channel (16) bounded by first and second reflective surfaces (14, 15) adapted to accommodate a fluid material therebetween and defining a plurality of regions in an array between those surfaces.
Abstract translation: 测定系统具有由第一和第二反射表面（14,15）限定的通道（16），其适于在其间容纳流体材料并且在这些表面之间限定阵列中的多个区域。
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3.发明申请NUMERICAL APERTURE INCREASING LENS (NAIL) TECHNIQUES FOR HIGH-RESOLUTION SUB-SURFACE IMAGING 审中-公开数字光学增强镜头（NAIL）技术用于高分辨率子表面成像
公开(公告)号：WO0079313A9
公开(公告)日：2002-08-01
申请号：PCT/US0040253
申请日：2000-06-20
Applicant: UNIV BOSTON , IPPOLITO STEPHEN B , UNLU M SELIM , GOLDBERG BENNETT B
Inventor： IPPOLITO STEPHEN B , UNLU M SELIM , GOLDBERG BENNETT B
CPC classification number: B82Y10/00 , G02B21/00 , G02B21/33 , G02B27/58 , G11B7/1374 , G11B7/1387 , G11B2007/13727
Abstract: A viewing enhancement lens (18 - NAIL) which functions to increase the numerical aperture or light gathering or focusing power of viewing optics such as a microscope (26) used to view structure within a substrate such as a semiconductor wafer or chip or of imaging optics such as media recorders. The result is to increase the resolution of the system by a factor of between n, and n , where n is the index of refraction of the lens substrate.
Abstract translation: 一种观看增强透镜（18-NAIL），其用于增加诸如用于观察诸如半导体晶片或芯片或成像光学元件之类的基板内的结构的诸如显微镜（26）的观察光学器件的数值孔径或聚光或聚焦能力 如媒体录像机。 结果是将系统的分辨率提高了n和n 2之间的系数，其中n是透镜基板的折射率。
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4.发明申请HIGH MAGNIFICATION SPECTRAL REFLECTANCE BIOSENSING WITH DISCRETE LIGHT SOURCES 审中-公开具有分离光源的高放大光谱反射生物传感
公开(公告)号：WO2011014282A3
公开(公告)日：2011-03-31
申请号：PCT/US2010033397
申请日：2010-05-03
Applicant: UNIV BOSTON , UNLU SELIM M , OZKUMUR EMRE I , DAABOUL GEORGE , VEDULA RAHUL S , GOLDBERG BENNETT B
Inventor： UNLU SELIM M , OZKUMUR EMRE I , DAABOUL GEORGE , VEDULA RAHUL S , GOLDBERG BENNETT B
IPC: G01N21/45 , G01B9/02 , G01B11/06 , G01N33/543 , G01N33/569
CPC classification number: G01N21/45 , G01B11/0625 , G01N2021/1776 , G01N2021/7779 , G01N2201/0627
Abstract: A spectral reflectance imaging device (100) for detecting biomolecular targets (126) includes an illumination source (101) that illuminates a substrate (122) with a plurality of separate wavelengths of incoherent light. The substrate includes an oxide layer (124) and a binding agent to selectively bind biomolecular targets to the substrate. An imaging device (130) captures the light reflected from or transmitted through the substrate and an image processing system (140) detects the biomolecular targets a function of the change in reflective properties of the substrate.
Abstract translation: 用于检测生物分子靶（126）的光谱反射成像装置（100）包括用多个分离的不相干光的波长照射衬底（122）的照明源（101）。 底物包括氧化物层（124）和用于选择性地将生物分子靶标结合到底物的结合剂。 成像装置（130）捕获从衬底反射或透射通过衬底的光，并且图像处理系统（140）检测生物分子靶标是衬底反射性能变化的函数。
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5.发明申请HIGH MAGNIFICATION SPECTRAL REFLECTANCE BIOSENSING WITH DISCRETE LIGHT SOURCES 审中-公开具有分离光源的高放大光谱反射生物传感
公开(公告)号：WO2011014282A2
公开(公告)日：2011-02-03
申请号：PCT/US2010/033397
申请日：2010-05-03
Applicant: TRUSTEES OF BOSTON UNIVERSITY , UNLU, Selim, M. , OZKUMUR, Emre, I. , DAABOUL, George , VEDULA, Rahul, S. , GOLDBERG, Bennett, B.
Inventor： UNLU, Selim, M. , OZKUMUR, Emre, I. , DAABOUL, George , VEDULA, Rahul, S. , GOLDBERG, Bennett, B.
CPC classification number: G01N21/45 , G01B11/0625 , G01N2021/1776 , G01N2021/7779 , G01N2201/0627
Abstract: A spectral reflectance imaging device for detecting biomolecular targets includes an illumination source that illuminates a substrate with a plurality of separate wavelengths of incoherent light. The substrate includes an oxide layer and a binding agent to selectively bind biomolecular targets to the substrate. An imaging device captures the light reflected from or transmitted through the substrate and an image processing system detects the biomolecular targets a function of the change in reflective properties of the substrate.
Abstract translation: 用于检测生物分子靶的光谱反射成像装置包括用多个单独波长的非相干光照射衬底的照明源。 底物包括氧化物层和用于选择性地将生物分子靶标结合到底物的结合剂。 成像装置捕获从基底反射或透射通过的光，并且图像处理系统检测生物分子靶是基底反射性能变化的函数。
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Patent Agency Ranking
公开(公告)号：WO2004083820A3
公开(公告)日：2005-01-27
申请号：PCT/US2004008558
申请日：2004-03-19
Applicant: UNIV BOSTON , UNLU SELIM M , BERGSTEIN DAVID A , RUANE MICHAEL F , GOLDBERG BENNETT B
Inventor： UNLU SELIM M , BERGSTEIN DAVID A , RUANE MICHAEL F , GOLDBERG BENNETT B
IPC: G01N20060101 , G01N21/64
CPC classification number: G01N21/7746 , B01L3/5027 , G01N21/0303 , G01N21/253
Abstract: An assay system having a channel (16) bounded by first and second reflective surfaces (14, 15) adapted to accommodate a fluid material therebetween and defining a plurality of regions in an array between those surfaces.
Abstract translation: 测定系统具有由第一和第二反射表面（14,15）限定的通道（16），其适于在其间容纳流体材料并且在这些表面之间限定阵列中的多个区域。
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公开(公告)号：WO2006116362A3
公开(公告)日：2009-05-14
申请号：PCT/US2006015566
申请日：2006-04-25
Applicant: UNIV BOSTON , UNLU SELIM M , BERGSTEIN DAVID A , RUANE MICHAEL F , GOLDBERG BENNETT B
Inventor： UNLU SELIM M , BERGSTEIN DAVID A , RUANE MICHAEL F , GOLDBERG BENNETT B
CPC classification number: G01N21/77 , B01J2219/00378 , B01J2219/00387 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , G01N21/45 , G01N21/75 , G01N33/54373 , G01N2021/7779 , G01N2201/061 , G02B21/34 , C12Q2565/619
Abstract: This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., DNA, RNA, and protein) using standard SiO2-based microarray technology.
Abstract translation: 本公开提供了用于无标记检测目的靶分子的方法和装置。 本公开的原理特别适用于使用标准的基于SiO 2的微阵列技术检测生物分子（例如DNA，RNA和蛋白质）。
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公开(公告)号：WO2004083820A2
公开(公告)日：2004-09-30
申请号：PCT/US2004/008558
申请日：2004-03-19
Applicant: TRUSTEES OF BOSTON UNIVERSITY , UNLU, Selim, M. , BERGSTEIN, David, A. , RUANE, Michael, F. , GOLDBERG, Bennett, B.
Inventor： UNLU, Selim, M. , BERGSTEIN, David, A. , RUANE, Michael, F. , GOLDBERG, Bennett, B.
IPC: G01N
CPC classification number: G01N21/7746 , B01L3/5027 , G01N21/0303 , G01N21/253
Abstract: An assay system having a channel bounded by first and second reflective surfaces adapted to accommodate a fluid material therebetween and defining a plurality of regions in an array between those surfaces with each region defining a resonant cavity and adapted to receive a capturing material on a surface thereof whereby a source of radiation illuminates each region to provide a standing wave of radiation of within the cavity indicative of binding of said capturing agent to material under investigation, a binding thereof being detected in response to radiation from each cavity indicative of a change in the standing wave pattern.
Abstract translation: 一种测定系统，其具有由第一和第二反射表面限定的通道，其适于在其间容纳流体材料并且在这些表面之间限定阵列中的多个区域，每个区域限定谐振腔并且适于在其表面上接收捕获材料 由此辐射源照射每个区域以提供在空腔内的辐射驻波，指示所述捕获剂与所研究的材料的结合，响应于来自每个空腔的辐射而被检测到的结合，其指示站立的变化 波纹。
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公开(公告)号：WO02070984A8
公开(公告)日：2003-04-24
申请号：PCT/US0149391
申请日：2001-12-19
Applicant: UNIV BOSTON , UENLUE M SELIM , SWAN ANNA , GOLDBERG BENNETT B , IPPOLITO STEPHEN , MOISEEV LEV , LIPOFF SAMUEL , TONG YUNJIE
Inventor： UENLUE M SELIM , SWAN ANNA , GOLDBERG BENNETT B , IPPOLITO STEPHEN , MOISEEV LEV , LIPOFF SAMUEL , TONG YUNJIE
CPC classification number: G01B9/02044 , G01B9/02023 , G01B9/04 , G01N21/4795 , G01N21/6458 , G01N2021/6417 , G01N2021/6441 , G02B21/22
Abstract: A method and apparatus for performing optical microscopy in one to three dimensions employs a spectral self-interference fluorescent microscopy technique that includes providing at least one fluorescent microscopy sample (220a, 220b), at least one objective lens (201), and a reflecting surface (204). The fluorescent sample is disposed between the objective lens and the reflecting surface, the distance (d1, d2) from the sample to the reflecting surface is several to several tens times an excitation wavelength. Excitation light (216) causes the fluorescent sample to emit light (214), at least a portion (214b) of which is reflected by the reflecting surface. The objective lens collects both the reflected light and the light emitted directly by the fluorescent sample (214a). The direct and reflected light interferences causing spectral oscillations in the emission spectrum. The periodicity and the peak wavelengths of the emission spectrum are then spectroscopically analyzed to determine the optical path length between the fluorescent sample and the reflecting surface.
Abstract translation: 用于在一到三维中执行光学显微镜的方法和装置采用光谱自干涉荧光显微镜技术，其包括提供至少一个荧光显微镜样品（220a，220b），至少一个物镜（201）和反射表面 （204）。 荧光试样配置在物镜与反射面之间，从样品到反射面的距离（d1，d2）为激发波长的数倍〜数十倍。 激发光（216）使得荧光样品发射光（214），其中至少一部分（214b）被反射表面反射。 物镜收集反射光和由荧光样品（214a）直接发射的光。 直接和反射的光干扰导致发射光谱中的光谱振荡。 然后对发射光谱的周期和峰值波长进行光谱分析，以确定荧光样品和反射表面之间的光程长度。
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公开(公告)号：WO2002070984A1
公开(公告)日：2002-09-12
申请号：PCT/US2001/049391
申请日：2001-12-19
Applicant: TRUSTEES OF BOSTON UNIVERSITY , ÜNLÜ, Selim, M. , SWAN, Anna , GOLDBERG, Bennett, B. , IPPOLITO, Stephen , MOISEEV, Lev , LIPOFF, Samuel , TONG, Yunjie
Inventor： ÜNLÜ, Selim, M. , SWAN, Anna , GOLDBERG, Bennett, B. , IPPOLITO, Stephen , MOISEEV, Lev , LIPOFF, Samuel , TONG, Yunjie
IPC: G01B9/02
CPC classification number: G01B9/02044 , G01B9/02023 , G01B9/04 , G01N21/4795 , G01N21/6458 , G01N2021/6417 , G01N2021/6441 , G02B21/22
Abstract: A method and apparatus for performing optical microscopy in one to three dimensions employs a spectral self-interference fluorescent microscopy technique that includes providing at least one fluorescent microscopy sample (220a, 220b), at least one objective lens (201), and a reflecting surface (204). The fluorescent sample is disposed between the objective lens and the reflecting surface, the distance (d1, d2) from the sample to the reflecting surface is several to several tens times an excitation wavelength. Excitation light (216) causes the fluorescent sample to emit light (214), at least a portion (214b) of which is reflected by the reflecting surface. The objective lens collects both the reflected light and the light emitted directly by the fluorescent sample (214a). The direct and reflected light interferences causing spectral oscillations in the emission spectrum. The periodicity and the peak wavelengths of the emission spectrum are then spectroscopically analyzed to determine the optical path length between the fluorescent sample and the reflecting surface.
Abstract translation: 用于在一到三维中执行光学显微镜的方法和装置采用光谱自干涉荧光显微镜技术，其包括提供至少一个荧光显微镜样品（220a，220b），至少一个物镜（201）和反射表面 （204）。 荧光试样配置在物镜与反射面之间，从样品到反射面的距离（d1，d2）为激发波长的数倍〜数十倍。 激发光（216）使得荧光样品发射光（214），其中至少一部分（214b）被反射表面反射。 物镜收集反射光和由荧光样品（214a）直接发射的光。 直接和反射的光干扰导致发射光谱中的光谱振荡。 然后对发射光谱的周期和峰值波长进行光谱分析，以确定荧光样品和反射表面之间的光程长度。
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