公开(公告)号：WO2011102931A3

公开(公告)日：2011-08-25

申请号：PCT/US2011/021714

申请日：2011-01-19

Applicant: HYCLONE LABORATORIES, INC. ,  STAHELI, Clinton, C. ,  JONES, Nephi, D. ,  GOODWIN, Michael, E.

Inventor： STAHELI, Clinton, C. ,  JONES, Nephi, D. ,  GOODWIN, Michael, E.

IPC: B01F3/04 ,  B01F7/16 ,  B01F7/18 ,  B01F15/00 ,  C12M1/06 ,  B01F7/00 ,  B01F15/06

Abstract: A system (10) for mixing a liquid solution or suspension includes a support housing (14) bounding a compartment and a collapsible bag (12) disposed within the compartment. A mixer (18) is disposed within the collapsible bag while a sparger (59) delivers a gas to the lower end of the collapsible bag. A gas outlet line (51) extends from an upper end of the collapsible bag to a condenser assembly (16). A gas exhaust line and a fluid collection line both extend from the condenser assembly.

公开(公告)号：WO2006093572A3

公开(公告)日：2006-09-08

申请号：PCT/US2006/000877

申请日：2006-01-11

Applicant: HYNETICS, LLC ,  BIBBO, Kenneth, L. ,  CANTER, Mark, A. ,  GOODWIN, Michael, E. ,  LARSEN, Jeremy, K. ,  JONES, Nephi, D.

Inventor： BIBBO, Kenneth, L. ,  CANTER, Mark, A. ,  GOODWIN, Michael, E. ,  LARSEN, Jeremy, K. ,  JONES, Nephi, D.

IPC: B01F7/16

Abstract: A system for mixing a liquid solution or suspension includes a collapsible container having an interior surface bounding a compartment, the compartment being adapted to hold a liquid solution or suspension. A mixer is enclosed within the compartment of the container. A shaft has a first end connected to the mixer within the compartment of the container and a second end disposed outside of the compartment, the shaft being selectively movable relative to the container. A gas pathway extends from a portion of the shaft disposed outside of the container to a portion of the shaft or mixer disposed within the compartment of the container, the gas pathway extending through at least a portion of the shaft.

公开(公告)号：WO2013009765A2

公开(公告)日：2013-01-17

申请号：PCT/US2012046095

申请日：2012-07-10

Applicant: HYCLONE LAB INC ,  GOODWIN MICHAEL E ,  LARSEN JEREMY K ,  DRAPER PATRICK L ,  KNUDSEN BRANDON M

Inventor： GOODWIN MICHAEL E ,  LARSEN JEREMY K ,  DRAPER PATRICK L ,  KNUDSEN BRANDON M

IPC: B65B3/00

CPC classification number: B65B1/04 ,  A61J1/10 ,  B65B3/003 ,  B65B3/02 ,  B65B3/04 ,  B65B51/02 ,  B65B51/225

Abstract: A fluid manifold system includes a manifold having at least portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. A plurality of receiving containers are in fluid communication with the fluid flow path of the manifold, each receiving container bounding a compartment. The receiving containers can be formed integral with the manifold by welding together a second portion of the opposing flexible sheets or can comprise separate containers that are coupled to the manifold.

Abstract translation: 流体歧管系统包括歧管，所述歧管具有焊接在一起以在其间形成流体流动路径的至少部分相对柔性片材，流体入口与流体流动路径连通。 多个接收容器与歧管的流体流动路径流体连通，每个接收容器限定隔室。 接收容器可以通过将相对的柔性片的第二部分焊接在一起而与歧管一体地形成，或者可以包括与歧管联接的单独的容器。

公开(公告)号：WO2012151223A1

公开(公告)日：2012-11-08

申请号：PCT/US2012/036027

申请日：2012-05-01

Applicant: HYCLONE LABORATORIES, INC. ,  ARKEMA, INC. ,  GOODWIN, Michael, E. ,  KRAMER, Heather, L. ,  ZERAFATI, Saeid

Inventor： GOODWIN, Michael, E. ,  KRAMER, Heather, L. ,  ZERAFATI, Saeid

IPC: B32B1/08 ,  B32B25/08 ,  B32B27/08 ,  B32B27/36 ,  B32B27/40 ,  F16L9/00 ,  F16L11/00 ,  F16L11/04

CPC classification number: B32B1/08 ,  B32B25/08 ,  B32B27/08 ,  B32B27/36 ,  B32B27/40 ,  F16L11/04

Abstract: A polymeric, multilayer, film structure includes a polyester elastomer layer (COPE) and a thermoplastic polyurethane layer (hereinafter "TPU"). Multilayer film structures that include COPE and TPU have been found to have good properties for use in making thin film bags, containers, and flexible tubing.

Abstract translation: 聚合物多层薄膜结构包括聚酯弹性体层（COPE）和热塑性聚氨酯层（以下称为“TPU”）。 已经发现包括COPE和TPU的多层膜结构具有用于制造薄膜袋，容器和柔性管的良好性能。

公开(公告)号：WO2005104706A2

公开(公告)日：2005-11-10

申请号：PCT/US2005/013920

申请日：2005-04-22

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S. A. ,  HYCLONE LABORATORIES, INC. ,  KUNAS, Kurt, T. ,  OAKLEY, Robert, V. ,  HASAN, Fauad, F. ,  GOODWIN, Michael, E. ,  LARSEN, Jeremy, K. ,  JONES, Nephi, D.

Inventor： KUNAS, Kurt, T. ,  OAKLEY, Robert, V. ,  HASAN, Fauad, F. ,  GOODWIN, Michael, E. ,  LARSEN, Jeremy, K. ,  JONES, Nephi, D.

IPC: C12M1/00 ,  C12M1/02 ,  C12M1/04 ,  C12M1/12

CPC classification number: C12M23/14 ,  B01F7/001 ,  B01F7/1695 ,  B01F7/22 ,  B01F15/00006 ,  B01F15/00831 ,  B01F15/0085 ,  B01F2215/0073 ,  C12M23/00 ,  C12M23/06 ,  C12M23/26 ,  C12M23/28 ,  C12M27/02 ,  C12M29/06 ,  Y10T29/49826

Abstract: The present invention relates to a stirred-tank reactor system and methods of preparing such systems. The present invention further encompasses the use of the stirred-tank reactor system as a disposable bioreactor and in kits with disposable elements.

Abstract translation: 本发明涉及搅拌釜反应器系统和制备这种系统的方法。 本发明进一步包括搅拌釜反应器系统作为一次性生物反应器和使用一次性元件的试剂盒的用途。

公开(公告)号：WO2011102931A2

公开(公告)日：2011-08-25

申请号：PCT/US2011021714

申请日：2011-01-19

Applicant: HYCLONE LAB INC ,  STAHELI CLINTON C ,  JONES NEPHI D ,  GOODWIN MICHAEL E

Inventor： STAHELI CLINTON C ,  JONES NEPHI D ,  GOODWIN MICHAEL E

IPC: B01F3/04

CPC classification number: C12M23/14 ,  B01D5/0072 ,  B01D47/05 ,  B01F3/04241 ,  B01F3/04531 ,  B01F7/00691 ,  B01F7/1695 ,  B01F7/18 ,  B01F7/22 ,  B01F15/00071 ,  B01F15/00831 ,  B01F15/0085 ,  B01F15/065 ,  B01F2003/04191 ,  B01F2003/04297 ,  B01F2003/04673 ,  B01F2003/04865 ,  B01F2003/04872 ,  B01F2003/04879 ,  B01F2003/04893 ,  B01F2003/04921 ,  B01F2015/061 ,  B01F2215/0073 ,  C12M23/26 ,  C12M23/34 ,  C12M27/02 ,  C12M29/00 ,  C12M29/06 ,  C12M29/24 ,  C12M37/00 ,  C12M41/14 ,  C12M41/18 ,  C12N1/10 ,  C12N1/12 ,  C12N1/14 ,  C12N1/20 ,  C12N5/00 ,  C12N5/04 ,  C12N5/10 ,  F28B1/02 ,  F28F3/12 ,  F28F21/06 ,  F28F2255/02

Abstract: A system for mixing a liquid solution or suspension includes a support housing bounding a compartment and a collapsible bag disposed within the compartment. A mixer is disposed within the collapsible bag while a sparger delivers a gas to the lower end of the collapsible bag. A gas outlet line extends from an upper end of the collapsible bag to a condenser assembly. A gas exhaust line and a fluid collection line both extend from the condenser assembly.

Abstract translation: 用于混合液体溶液或悬浮液的系统包括限定隔室的支撑壳体和设置在隔室内的可折叠袋。 混合器设置在可折叠袋内，而喷射器将气体输送到可折叠袋的下端。 气体出口管线从可折叠袋的上端延伸到冷凝器组件。 排气管线和流体收集管线都从冷凝器组件延伸出来。

公开(公告)号：WO2008131442A3

公开(公告)日：2008-12-24

申请号：PCT/US2008061337

申请日：2008-04-23

Applicant: HYCLONE LAB INC ,  BILSTAD ARNOLD C ,  BUCHANAN BRADLEY H ,  DENNEHEY MICHAEL T ,  GOODWIN MICHAEL E ,  LARSEN JEREMY K ,  WOODS WHITT F

Inventor： BILSTAD ARNOLD C ,  BUCHANAN BRADLEY H ,  DENNEHEY MICHAEL T ,  GOODWIN MICHAEL E ,  LARSEN JEREMY K ,  WOODS WHITT F

IPC: A61M39/14 ,  B29C65/14 ,  B29C65/50

CPC classification number: A61M39/143 ,  A61M39/12 ,  A61M39/16 ,  B29C65/02 ,  B29C65/06 ,  B29C65/08 ,  B29C65/1412 ,  B29C65/1435 ,  B29C65/1441 ,  B29C65/1445 ,  B29C65/1467 ,  B29C65/148 ,  B29C65/16 ,  B29C65/48 ,  B29C65/7473 ,  B29C66/0242 ,  B29C66/1142 ,  B29C66/1162 ,  B29C66/322 ,  B29C66/5221 ,  B29C66/5223 ,  B29C66/5229 ,  B29C66/52293 ,  B29C66/52297 ,  B29C66/52298 ,  B29C66/534 ,  B29C66/54 ,  B29C66/71 ,  B29C66/73921 ,  B29C66/80 ,  B29C66/81267 ,  B29K2027/16 ,  B29K2101/12 ,  B29K2995/0025 ,  B29K2995/0026 ,  F16L29/005 ,  F16L2201/44 ,  B29K2071/00 ,  B29K2069/00 ,  B29K2033/12 ,  B29K2033/08 ,  B29K2027/12

Abstract: A system for forming a fluid connection includes a first connector (12) and a second connector (14). Both connectors include a tubular body (18,18') having a membrane (19,19') mounted on a distal end (27) thereof. A support member (16) or other fastener (214,220) facilitates the coupling of the connectors together so that the membranes are abutted together. Radiant or other form of energy is applied to the abutted membranes so as to sterilize the membranes and melt the membranes so that a passage is formed therethrough.

Abstract translation: 用于形成流体连接的系统包括第一连接器（12）和第二连接器（14）。 两个连接器包括具有安装在其远端（27）上的膜（19,19'）的管状体（18,18'）。 支撑构件（16）或其它紧固件（214,220）有助于将连接器耦合在一起，使得膜抵靠在一起。 将辐射或其他形式的能量施加到邻接的膜上，以便对膜进行灭菌并熔化膜，使得通过其形成通道。

公开(公告)号：WO2013049692A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/058086

申请日：2012-09-28

Applicant: HYCLONE LABORATORIES, INC. ,  GOODWIN, Michael, E. ,  JONES, Nephi, D. ,  WEST, Derik, R.

Inventor： GOODWIN, Michael, E. ,  JONES, Nephi, D. ,  WEST, Derik, R.

IPC: B01F3/04 ,  B01F15/00 ,  C12M1/06

CPC classification number: B01F3/04269 ,  B01F15/0085 ,  B01F2003/04148 ,  B01F2003/04191 ,  B01F2003/04297 ,  B01F2003/04326 ,  B01F2003/04347 ,  B01F2003/04361 ,  B01F2215/0073 ,  C12M23/14 ,  C12M23/26 ,  C12M23/40 ,  C12M29/06

Abstract: A container assembly (13) includes a flexible bag having an interior surface bounding a chamber (40) and an opposing exterior surface, the bag having a top end wall (48), a bottom end wall (50), and an encircling sidewall (42) extending therebetween, the bottom end wall including a first polymeric sheet (60) overlying a second polymeric sheet (66). A first weld line welds the first polymeric sheet to the second polymeric sheet, the first weld line bounding a first sparging area formed between the first polymeric sheet and the second polymeric sheet. A plurality of first perforations are formed through a portion of the first polymeric sheet that overlies the first sparging area so that gas can pass from the first sparging area, through the first perforations and into the chamber of the bag.

Abstract translation: 容器组件（13）包括具有限定室（40）和相对的外表面的内表面的柔性袋，所述袋具有顶端壁（48），底端壁（50）和环绕侧壁 42），所述底端壁包括覆盖在第二聚合物片（66）上的第一聚合物片（60）。 第一焊接线将第一聚合物片材焊接到第二聚合物片材，第一焊接线限定形成在第一聚合物片材和第二聚合物片材之间的第一喷射区域。 通过覆盖在第一喷射区域上的第一聚合物片材的一部分形成多个第一穿孔，使得气体可以从第一喷射区域穿过第一穿孔并进入袋的腔室。

公开(公告)号：WO2006116069A1

公开(公告)日：2006-11-02

申请号：PCT/US2006/015070

申请日：2006-04-21

Applicant: HYCLONE LABORATORIES, INC. ,  GOODWIN, Michael, E. ,  LARSEN, Jeremy, K.

Inventor： GOODWIN, Michael, E. ,  LARSEN, Jeremy, K.

IPC: F16L23/032

CPC classification number: C12M23/14 ,  B29C65/02 ,  B29C65/04 ,  B29C65/08 ,  B29C65/48 ,  B29C66/5344 ,  C12M29/00

Abstract: A tube port includes a tubular first stem having an interior surface and an exterior surface extending between a first end and a longitudinally spaced apart second end. The interior surface bounds a passage that longitudinally extends through the first stem. The tube port also includes a flange encircling and radially outwardly projecting from the first end of the first stem. The flange and the first stem are integrally formed as a unitary member comprised of a flexible elastomeric material having a durometer on a Shore A scale with a value of less than 90.

Abstract translation: 管口包括具有内表面和在第一端和纵向间隔开的第二端之间延伸的外表面的管状第一杆。 内表面限定了纵向延伸穿过第一杆的通道。 管口还包括从第一杆的第一端围绕并径向向外突出的凸缘。 凸缘和第一杆一体地形成为整体构件，其由柔性弹性体材料组成，柔性弹性体材料具有肖氏A级的硬度小于90的值。

公开(公告)号：WO2013009765A3

公开(公告)日：2013-01-17

申请号：PCT/US2012/046095

申请日：2012-07-10

Applicant: HYCLONE LABORATORIES, INC. ,  GOODWIN, Michael, E. ,  LARSEN, Jeremy, K. ,  DRAPER, Patrick, L. ,  KNUDSEN, Brandon, M.

Inventor： GOODWIN, Michael, E. ,  LARSEN, Jeremy, K. ,  DRAPER, Patrick, L. ,  KNUDSEN, Brandon, M.

IPC: B65B3/00

Abstract: A fluid manifold system includes a manifold having at least portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. A plurality of receiving containers are in fluid communication with the fluid flow path of the manifold, each receiving container bounding a compartment. The receiving containers can be formed integral with the manifold by welding together a second portion of the opposing flexible sheets or can comprise separate containers that are coupled to the manifold.