公开(公告)号：WO2013036775A1

公开(公告)日：2013-03-14

申请号：PCT/US2012/054176

申请日：2012-09-07

Applicant: AXXIA PHARMACEUTICALS, LLC ,  HOLL, Richard, J. ,  HARTMAN, Katherine ,  GROSSMAN, Stuart, A. ,  POLLOCK, Wayne, C.

Inventor： HOLL, Richard, J. ,  HARTMAN, Katherine ,  GROSSMAN, Stuart, A. ,  POLLOCK, Wayne, C.

IPC: A61K9/00 ,  A61K31/485 ,  A61K47/34

CPC classification number: A61K9/0002 ,  A61K9/0024 ,  A61K31/485 ,  A61K47/34

Abstract: Implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants are provided. In particular, subcutaneous drug delivery systems having a biocompatible thermoplastic elastomeric polymer matrix, a therapeutic agent embedded homogeneously in said matrix, and a biocompatible drug impermeable cross-linked silicone polymer coating said matrix and methods of making the same are provided.

Abstract translation: 提供用于递送治疗剂如阿片样物质的植入物，以及这种植入物的制造和用途。 特别地，提供了具有生物相容性热塑性弹性体聚合物基质，均匀地嵌入所述基质中的治疗剂和涂覆所述基质的生物相容性药物不可渗透交联的硅氧烷聚合物的皮下药物递送系统及其制备方法。

公开(公告)号：WO2010120389A8

公开(公告)日：2010-10-21

申请号：PCT/US2010/001166

申请日：2010-04-19

Applicant: AXXIA PHARMACEUTICALS, LLC ,  POLLOCK, Wayne, C. ,  GROSSMAN, Stuart A. ,  OWENS, Albert, H. Jr.

Inventor： POLLOCK, Wayne, C. ,  GROSSMAN, Stuart A. ,  OWENS, Albert, H. Jr.

IPC: A61K47/34 ,  A61K9/00 ,  A61K31/485 ,  B29C47/06

Abstract: The subject invention relates to implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants.

公开(公告)号：WO2009051819A1

公开(公告)日：2009-04-23

申请号：PCT/US2008/011908

申请日：2008-10-17

Applicant: AXXIA PHARMACEUTICALS, LLC ,  POLLOCK, Wayne, C. ,  GROSSMAN, Stuart, A. ,  OWENS, Albert, H.

Inventor： POLLOCK, Wayne, C. ,  GROSSMAN, Stuart, A. ,  OWENS, Albert, H.

IPC: A61F2/00

CPC classification number: B29C47/06 ,  A61K9/0024 ,  A61K31/485 ,  A61K47/34 ,  B29C45/0001 ,  B29C47/0016 ,  B29C47/0021 ,  B29K2105/0035

Abstract: Implants are disclosed for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants.

Abstract translation: 公开了用于递送治疗剂如阿片样物质的植入物，以及这种植入物的制造和用途。

公开(公告)号：WO2008144232A3

公开(公告)日：2009-01-29

申请号：PCT/US2008062922

申请日：2008-05-07

Applicant: UNIV JOHNS HOPKINS ,  THERATAXIS LLC ,  RAGHAVAN RAGHU ,  GROSSMAN STUART A

Inventor： RAGHAVAN RAGHU ,  GROSSMAN STUART A

IPC: A61B5/05

CPC classification number: A61B34/10 ,  A61B6/461 ,  A61B6/481 ,  A61B6/501 ,  A61B90/00 ,  A61B2034/101 ,  A61B2034/252 ,  A61N2005/1021 ,  G06F19/321 ,  G06T7/0012 ,  G06T2207/30016 ,  G16H50/50 ,  Y02A90/24 ,  Y02A90/26

Abstract: A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising a computer, and an application configured to operate with the computer. The application is capable of: obtaining radiological imaging from the brain; obtaining anatomical information from the radiological imaging within a region of interest within the brain; constructing a physiological states model which assesses physiological states of the region of interest; locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model; and creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.

Abstract translation: 一种用于提供关于神经系统疾病的治疗的生理状况和效果的信息的治疗模拟器，包括计算机以及被配置为与所述计算机一起操作的应用。 该应用能够：从脑获得放射成像; 从大脑内感兴趣的区域内的放射成像获得解剖信息; 构建评估感兴趣区域的生理状态的生理状态模型; 利用解剖信息和生理状态模型确定颗粒物质的间质流的来源并获得间质流的路径的流体电导率; 并创建颗粒物质的流动模型，其使用间隙流和流体电导率来评估流动速率和间隙压力变化。

公开(公告)号：WO2008144232A2

公开(公告)日：2008-11-27

申请号：PCT/US2008/062922

申请日：2008-05-07

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  THERATAXIS, LLC ,  RAGHAVAN, Raghu ,  GROSSMAN, Stuart, A.

Inventor： RAGHAVAN, Raghu ,  GROSSMAN, Stuart, A.

IPC: A61B19/00 ,  G06G7/48 ,  A61N1/00 ,  A61B5/05

CPC classification number: A61B34/10 ,  A61B6/461 ,  A61B6/481 ,  A61B6/501 ,  A61B90/00 ,  A61B2034/101 ,  A61B2034/252 ,  A61N2005/1021 ,  G06F19/00 ,  G06F19/321 ,  G06T7/0012 ,  G06T2207/30016 ,  G16H50/50 ,  Y02A90/24 ,  Y02A90/26

Abstract: A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising a computer, and an application configured to operate with the computer. The application is capable of: obtaining radiological imaging from the brain; obtaining anatomical information from the radiological imaging within a region of interest within the brain; constructing a physiological states model which assesses physiological states of the region of interest; locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model; and creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.

Abstract translation: 一种用于提供关于神经系统疾病的治疗的生理状况和效果的信息的治疗模拟器，包括计算机以及被配置为与所述计算机一起操作的应用。 该应用能够：从脑获得放射成像; 从大脑内感兴趣的区域内的放射成像获得解剖信息; 构建评估感兴趣区域的生理状态的生理状态模型; 利用解剖信息和生理状态模型确定颗粒物质的间质流的来源并获得间质流的路径的流体电导率; 并创建颗粒物质的流动模型，其使用间隙流和流体电导率来评估流动速率和间隙压力变化。