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公开(公告)号：JP2008191163A
公开(公告)日：2008-08-21
申请号：JP2008064290
申请日：2008-03-13
Applicant: Guava Technologies Inc , グアヴァ テクノロジーズ インコーポレイテッド
Inventor： GOIX PHILIPPE J , LINGANE PAUL J , PHI-WILSON JANETTE T
CPC classification number: G01N15/1404 , G01N21/64
Abstract: PROBLEM TO BE SOLVED: To provide a particle analyzer having a high selectivity for particles. SOLUTION: In the particle analyzer, labeled particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by the particles is detected by a detector to count all particles. An emitted fluorescent illumination is detected by using the labeled particles, and the output signals from a fluorescent detector and a scatter detector are processed to provide an analysis of the particles. COPYRIGHT: (C)2008,JPO&INPIT
Abstract translation: 要解决的问题：提供对颗粒具有高选择性的颗粒分析仪。 解决方案：在颗粒分析仪中，待分析的标记颗粒通过毛细管中的预定体积被照亮的悬浮毛细管来绘制。 通过检测器检测由颗粒散射的照明以计数所有颗粒。 通过使用标记的颗粒检测发射的荧光照明，并且处理来自荧光检测器和散射检测器的输出信号以提供对颗粒的分析。 版权所有（C）2008，JPO＆INPIT
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公开(公告)号：JP2010204120A
公开(公告)日：2010-09-16
申请号：JP2010129736
申请日：2010-06-07
Applicant: Guava Technologies Inc , グアヴァ テクノロジーズ インコーポレイテッド
Inventor： DANIELZADEH ROBERT , OLSON KEITH R
IPC: G01N33/543 , C12Q1/68 , C12Q1/70 , G01N21/64 , G01N33/53 , G01N33/569 , G01N33/58 , G01N33/68 , G01N33/74
CPC classification number: G01N33/54306 , G01N33/54366 , G01N33/569 , G01N33/56983 , G01N33/582 , G01N33/585 , G01N33/6863 , G01N33/74
Abstract: PROBLEM TO BE SOLVED: To provide a composition and method for analyzing a certain sample to determine existence of one or more kinds of target specimens. SOLUTION: The method for detecting the target specimen includes (a) a process of inhibiting coupling between an antibody and the target specimen with a microparticle containing competitive inhibitor of this target specimen, and (b) a process of measuring the antibody coupled with the competitive inhibitor and detecting the target specimen when the microparticle passes a micro capillary cytometer optically coupled to a fluorescent light emitting device. COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 要解决的问题：提供用于分析某一样品以确定一种或多种目标样品的存在的组合物和方法。 检测靶标的方法包括：（a）使用该目标标本的含有竞争性抑制剂的微粒抑制抗体与靶标本体的结合的方法，（b）测定抗体偶联 与竞争性抑制剂并且当微粒通过光学耦合到荧光发光器件的微毛细血管细胞仪时检测靶标本。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2010017188A
公开(公告)日：2010-01-28
申请号：JP2009211291
申请日：2009-09-14
Applicant: Guava Technologies Inc , グアヴァ テクノロジーズ インコーポレイテッド
Inventor： GOIX PHILIPPE
CPC classification number: G01N15/1484 , G01N15/1456 , G01N21/64 , G01N2021/0346
Abstract: PROBLEM TO BE SOLVED: To disclose a method and apparatus for detecting a fluorescent substance tagged to a microparticle.
SOLUTION: The device comprises a single capillary flow carrier system for transporting the microparticle past a selected location, a source of electromagnetic radiation for irradiating the substance tagged to the microparticle and a detection system for measuring fluorescent light emitted from the substance at the selected location. The method comprises transporting the microparticle to a selected location, irradiating a fluorescent substance tagged to the microparticle, and measuring the fluorescent light emitted from the fluorescent substance at the selected location.
COPYRIGHT: (C)2010,JPO&INPITAbstract translation: 待解决的问题：公开一种用于检测标记有微粒的荧光物质的方法和装置。 解决方案：该装置包括用于将微粒传送通过选定位置的单个毛细管流动载体系统，用于照射标记到微粒上的物质的电磁辐射源和用于测量在该物质上发射的荧光的检测系统 选定位置 该方法包括将微粒输送到所选择的位置，照射标记到微粒上的荧光物质，以及测量在选定位置从荧光物质发射的荧光。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：CA2539452A1
公开(公告)日：2005-03-31
申请号：CA2539452
申请日：2004-09-17
Applicant: GUAVA TECHNOLOGIES INC
Inventor： DANIELZADEH ROBERT , OLSON KEITH R
IPC: G01N33/566 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/569 , G01N33/58 , G01N33/68 , G01N33/74
Abstract: A method of detecting first and second analytes includes providing a mixture containing first analytes and second analytes; adding microparticles of a first size coated with first competitive inhibitors that compete with the first analytes for binding to first antibodies to the first analytes, and adding microparticles of a second size coated with second competitive inhibitors that compete with the second analytes for binding to first antibodies to the second analytes, adding second antibodies specific to the first antibodies to the first analytes and second antibodies specific to the first antibodies to the second analytes, wherein the second antibodies specific to the first antibodies to the first analytes are labeled with a first fluorescent moiety, and the second antibodies specific to the first antibodies to the second analytes are labeled with a second fluorescent moiety
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公开(公告)号：CA2664456C
公开(公告)日：2013-12-31
申请号：CA2664456
申请日：2007-09-27
Applicant: GUAVA TECHNOLOGIES INC
Inventor： PITTARO RICHARD , GOLDMAN BRUCE , LEFEBVRE RAY , KING DAVID A
IPC: G01N15/10
Abstract: A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.
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Patent Agency Ranking
公开(公告)号：CA2293426A1
公开(公告)日：1998-12-17
申请号：CA2293426
申请日：1998-06-09
Applicant: GUAVA TECHNOLOGIES INC
Inventor： GOIX PHILIPPE
Abstract: A method and apparatus for detecting a fluorescent substance tagged to a microparticle are described. The device comprises a single capillary flow carrier system for transporting the microparticle past a a selected location, a source of electromagnetic radiation for irradiating the substance tagged to the microparticle, and a detection system for measuring fluorescent light emitted from the substance at the selected location. The method comprises transporting the microparticle to a selected location, irradiating a fluorescent substance tagged to the microparticle, and measuring the fluorescent light emitted from the fluorescent substance at the selected location.
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公开(公告)号：ES2295353T3
公开(公告)日：2008-04-16
申请号：ES02739288
申请日：2002-05-16
Applicant: GUAVA TECHNOLOGIES INC
Inventor： KOCHY THOMAS E , O'NEILL ROGER A , SMILEY TERAH W , SMITH VIDAL O
Abstract: Una célula de flujo intercambiable (31) para su uso con un bloque de citómetro (32) que comprende: un cuerpo de la célula de flujo alargado adaptado para la inserción reversible en el bloque del citómetro y que tiene una longitud; caracterizada porque en dicho cuerpo de la célula de flujo se proporciona un hueco que se prolonga externamente a lo largo de al menos parte de su longitud; caracterizada además porque comprende: un capilar (15) transportado por dicho cuerpo de la célula de flujo y que tiene una sección dispuesta dentro del hueco; y elementos de referencia separados en dicho cuerpo para engranar la sección del capilar dentro del hueco para de este modo colocar de forma precisa el capilar (15) con respecto al cuerpo de la célula de flujo.
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公开(公告)号：AU2002326680A1
公开(公告)日：2003-03-03
申请号：AU2002326680
申请日：2002-08-15
Applicant: GUAVA TECHNOLOGIES INC
Inventor： PHI-WILSON JANETTE T
IPC: C12N5/06 , G01N33/50 , G01N33/531 , G01N33/543 , C12Q1/32
Abstract: A cell separation composition and system is described. The composition includes a linker that is able to permeate the cell membranes. The linker has one end coupled to an intracellular marker that binds to molecules in target cells and an extracellular component bond to the other end and used to separate the target cells in a cell mixture.
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公开(公告)号：AU8875001A
公开(公告)日：2002-03-22
申请号：AU8875001
申请日：2001-09-05
Applicant: GUAVA TECHNOLOGIES INC
Inventor： GOIX PHILIPPE J , LINGANE PAUL J , PHI-WILSON JANETTE T
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公开(公告)号：DE60223370T2
公开(公告)日：2008-02-28
申请号：DE60223370
申请日：2002-05-16
Applicant: GUAVA TECHNOLOGIES INC
Inventor： KOCHY THOMAS E , O'NEILL ROGER A , SMILEY TERAH W , SMITH VIDAL O
Abstract: There is provided a flow cell assembly in which a shuttle supports and positions a capillary with its end extending beyond the shuttle. The flow cell assembly facilitates the replacement of a flow cell which is damaged or with flow cells having capillaries of different size or shape.
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