公开(公告)号：WO1996002493A1

公开(公告)日：1996-02-01

申请号：PCT/FR1995000941

申请日：1995-07-12

Applicant: RHONE-POULENC CHIMIE ,  CROCHEMORE, Michel ,  GUIDOT, Gilbert

Inventor： RHONE-POULENC CHIMIE

IPC: C07C211/52

CPC classification number: C07C201/08 ,  C07C209/365 ,  C07C231/02 ,  C07C231/12 ,  C07C233/15 ,  C07C205/12 ,  C07C211/52

Abstract: A method useful for the synthesis of a meta-substituted nitrogen derivative, comprising the step of deaminating an ortho- and/or para-substituted nitroaniline of the aniline function. The method is useful for organic synthesis.

Abstract translation: 用于合成间位取代的氮衍生物的方法，包括使苯胺官能团的邻位和/或对位取代的硝基苯胺脱氨的步骤。 该方法对于有机合成是有用的。

公开(公告)号：WO02055487A3

公开(公告)日：2002-11-28

申请号：PCT/FR0200075

申请日：2002-01-10

Applicant: RHODIA CHIMIE SA ,  SAINT-JALMES LAURENT ,  SCHANEN VINCENT ,  GUIDOT GILBERT ,  KEMPF HUBERT

Inventor： SAINT-JALMES LAURENT ,  SCHANEN VINCENT ,  GUIDOT GILBERT ,  KEMPF HUBERT

IPC: C07C265/12 ,  C07B39/00 ,  C07B61/00 ,  C07C263/16

CPC classification number: C07C263/16 ,  C07B39/00 ,  C07C265/12

Abstract: The invention concerns a method for using a carbamoyl fluoride as fluorinating agent. Said method consists in treating a derivative bearing a halogen-containing carbon, with a carbamoyl fluoride at a temperature not less than 70 DEG C and in maintaining the ratio between the sum of hydrofluoric acid (HF) and carbamoyl fluoride as well as between the sum of exchangeable halogen atoms, isocyanate functions and carbamoyl fluoride [(HF + carbamoyl fluoride)/(exchangeable halogen + isocyanate + carbamoyl fluoride)] at a value not more than 1.2; then in carrying out a catalysis process with tin, antimony and/or titanium salt. The invention is applicable to synthesis of fluorinated derivatives.

Abstract translation: 本发明涉及使用氨基甲酰氟作为氟化剂的方法。 所述方法包括在不低于70℃的温度下用氨基甲酰氟处理带有含卤素碳的衍生物，并保持氢氟酸（HF）和氨基甲酰氟的总量之比以及总和 可交换的卤素原子，异氰酸酯官能团和氨基甲酰氟[（HF +氨基甲酰氟）/（可交换的卤素+异氰酸酯+氨基甲酰氟）]的值不大于1.2; 然后用锡，锑和/或钛盐进行催化过程。 本发明适用于氟化衍生物的合成。

公开(公告)号：WO1996016926A1

公开(公告)日：1996-06-06

申请号：PCT/FR1995001575

申请日：1995-11-29

Applicant: RHONE-POULENC CHIMIE ,  CORDIER, Georges ,  GUIDOT, Gilbert ,  MARION, Philippe ,  MERCIER, Claude

Inventor： RHONE-POULENC CHIMIE

IPC: C07C209/36

CPC classification number: C07C209/36 ,  C07C211/52

Abstract: A compound of formula (II), wherein n is 1-5, Z is a radical that is stable under catalytic hydrogenation conditions, p is less than 5-n, X is a radical capable of undergoing hydrogenolysis, and q is from 0 to 5-(n + p), is subjected to catalytic hydrogenation in a catalyst-containing liquid medium under hydrogen pressure. The compound of formula (II) is fed into the medium gradually so that the content of the compound of formula (II) in the liquid does not exceed 1000 ppm by weight. A compound of formula (I) is selectively formed.

Abstract translation: 式（II）化合物，其中n为1-5，Z为在催化氢化条件下稳定的基团，p小于5-n，X为能够进行氢解的基团，q为0至 5-（n + p）在氢气压力下在含催化剂的液体介质中进行催化氢化。 将式（II）化合物逐渐加入到培养基中，使得液体中式（II）化合物的含量不超过1000重量ppm。 选择性地形成式（I）的化合物。