公开(公告)号：US20190150729A1

公开(公告)日：2019-05-23

申请号：US16308901

申请日：2017-06-15

Applicant: David Huang ,  Gangjun Liu ,  Yali Jia

Inventor： David Huang ,  Gangjun Liu ,  Yali Jia

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  A61B5/11 ,  A61B5/02

Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.

公开(公告)号：US20160317020A1

公开(公告)日：2016-11-03

申请号：US15141626

申请日：2016-04-28

Applicant: Gangjun Liu ,  David Huang ,  Yali Jia

Inventor： Gangjun Liu ,  David Huang ,  Yali Jia

IPC: A61B3/00 ,  A61B3/12 ,  G01B9/02

CPC classification number: A61B3/0025 ,  A61B3/102 ,  A61B3/1233 ,  G01B9/02004 ,  G01B9/02045 ,  G01B9/02076 ,  G01B9/02091

Abstract: Disclosed are methods of imaging vascular flow using optical coherence tomography. The methods involve calculating an OCT phase difference and an OCT phase gradient from interference fringes acquired from B-scans. The methods can be implemented in a split-spectrum embodiment to enhance the signal to noise ratio of vascular flow images. The methods also obviate the need for correction of bulk motion and laser trigger jitter-induced phase artifacts.

Abstract translation: 公开了使用光学相干断层扫描成像血管流动的方法。 该方法涉及从B扫描获得的干涉条纹计算OCT相位差和OCT相位梯度。 该方法可以在分裂实施例中实现，以增强血管图像的信噪比。 这些方法也避免了校正体积运动和激光触发抖动引起的相位伪影的需要。

公开(公告)号：US20160232427A1

公开(公告)日：2016-08-11

申请号：US14930977

申请日：2015-11-03

Applicant: David HUANG ,  Yali JIA ,  Ashwath JAYAGOPAL ,  Gangjun LIU

Inventor： David HUANG ,  Yali JIA ,  Ashwath JAYAGOPAL ,  Gangjun LIU

IPC: G06K9/62 ,  G01N33/483 ,  G06T5/40

CPC classification number: G06K9/6212 ,  G01B9/02004 ,  G01B9/02044 ,  G01B9/02083 ,  G01B9/02091 ,  G01N21/4795 ,  G01N33/4833 ,  G06T5/40 ,  G06T2207/10101 ,  G06T2207/30024

Abstract: Methods and systems for detecting a gold nanorod (GNR) contrast agent in an optical coherence tomography (OCT) image of a sample are disclosed. In one example approach, a method comprises separating the OCT image at the location into short and long wavelength halves around a center wavelength of the OCT system, calculating a ratio between the short and long wavelength halves, and indicating a gold nanorod contrast agent at the location based on the ratio. In some examples, spectral fractionation may be employed to further divide the short and long wavelength halves into sub-bands to increase spectral contrast, reduce noise, and increase accuracy in detecting GNR in a sample.

Abstract translation: 公开了用于在样品的光学相干断层摄影（OCT）图像中检测金纳米棒（GNR）造影剂的方法和系统。 在一个示例性方法中，一种方法包括将该位置处的OCT图像分离成在OCT系统的中心波长周围的短波长和长波长半径，计算短波长和长波长半部之间的比率，并且在该波长处指示金纳米棒对比剂 基于比例的位置。 在一些示例中，可以采用频谱分级来进一步将短波长和长波长半部分成子带，以增加样本中的GNR检测的光谱对比度，降低噪声，并提高准确度。

公开(公告)号：US08582096B2

公开(公告)日：2013-11-12

申请号：US12969295

申请日：2010-12-15

Applicant: Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

Inventor： Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

IPC: G01J3/44

CPC classification number: G01J3/44 ,  A61B1/00165 ,  A61B1/043 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/441 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/08 ,  G01N2201/0866

Abstract: A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.

Abstract translation: 适用于厚组织CARS成像的纤维输送探针是实用的。 所公开的设计基于两个进展。 首先，CARS探针设计中的一个主要问题是在通过FWM工艺生成的二氧化硅输送纤维中存在非常强的反斯托克斯组分。 没有适当的光谱过滤，该组件会影响来自组织样本的CARS图像。 本发明的所示实施例通过使用用于激发传递和信号检测的单独光纤来有效地抑制这种寄生的反斯托克斯分量，这允许并入用于反斯托克斯抑制的二向色光学器件。 其次，通过在检测通道中使用大型核心多模光纤，优化了样品背散射CARS辐射的检测。 该方案可生成高品质的CARS图像，无需检测器孔径效果。 该光纤传送探针的小型化导致临床CARS成像的实用手持式探头。

公开(公告)号：US10327631B2

公开(公告)日：2019-06-25

申请号：US14996134

申请日：2016-01-14

Applicant: David Huang ,  Gangjun Liu

Inventor： David Huang ,  Gangjun Liu

IPC: G01B9/02 ,  A61B3/10 ,  A61B3/00 ,  A61B3/12

Abstract: Disclosed herein are methods and systems for aligning swept-source optical coherence tomography (SS-OCT) spectral interferograms to a reference spectral interferogram based on signal information (e.g., amplitude or phase) at a fixed-pattern noise location to reduce residual fixed-pattern noise and improve the phase stability of SS-OCT systems.

公开(公告)号：US20160206195A1

公开(公告)日：2016-07-21

申请号：US14996134

申请日：2016-01-14

Applicant: David Huang ,  Gangjun Liu

Inventor： David Huang ,  Gangjun Liu

IPC: A61B3/10 ,  A61B3/12 ,  A61B3/00 ,  G01B9/02

CPC classification number: A61B3/102 ,  A61B3/0025 ,  A61B3/1233 ,  G01B9/02004 ,  G01B9/0207 ,  G01B9/02091

Abstract: Disclosed herein are methods and systems for aligning swept-source optical coherence tomography (SS-OCT) spectral interferograms to a reference spectral interferogram based on signal information (e.g., amplitude or phase) at a fixed-pattern noise location to reduce residual fixed-pattern noise and improve the phase stability of SS-OCT systems.

Abstract translation: 本文公开了用于将扫频光学相干断层扫描（SS-OCT）光谱干涉图基于固定模式噪声位置处的信号信息（例如，幅度或相位）对准参考光谱干涉图进行对准以减少残余固定模式的方法和系统 提高SS-OCT系统的相位稳定性。

公开(公告)号：US20110282166A1

公开(公告)日：2011-11-17

申请号：US12969295

申请日：2010-12-15

Applicant: Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

Inventor： Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

IPC: A61B5/1455 ,  A61B6/00 ,  G01J3/44

CPC classification number: G01J3/44 ,  A61B1/00165 ,  A61B1/043 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/441 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/08 ,  G01N2201/0866

Abstract: A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.

Abstract translation: 适用于厚组织CARS成像的纤维输送探针是实用的。 所公开的设计基于两个进展。 首先，CARS探针设计中的一个主要问题是在通过FWM工艺生成的二氧化硅输送纤维中存在非常强的反斯托克斯组分。 没有适当的光谱过滤，该组件会影响来自组织样本的CARS图像。 本发明的所示实施例通过使用用于激发传递和信号检测的单独光纤来有效地抑制这种寄生的反斯托克斯分量，这允许并入用于反斯托克斯抑制的二向色光学器件。 其次，通过在检测通道中使用大型核心多模光纤，优化了样品背散射CARS辐射的检测。 该方案可生成高品质的CARS图像，无需检测器孔径效果。 该光纤传送探针的小型化导致临床CARS成像的实用手持式探头。