公开(公告)号：WO2012033842A2

公开(公告)日：2012-03-15

申请号：PCT/US2011/050704

申请日：2011-09-07

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  HAYWORTH, Kenneth, Jeffrey ,  SCHALEK, Richard ,  TAPIA, Juan, Carlos ,  KASTHURI, Narayanan ,  LICHTMAN, Jeff

Inventor： HAYWORTH, Kenneth, Jeffrey ,  SCHALEK, Richard ,  TAPIA, Juan, Carlos ,  KASTHURI, Narayanan ,  LICHTMAN, Jeff

IPC: G01N35/00 ,  G01N1/06 ,  G01N33/48

CPC classification number: G01N1/06 ,  A61B16/00 ,  G01N35/00009 ,  G01N2001/065 ,  G01N2001/066

Abstract: Methods, apparatuses and systems for facilitating automated or semi- automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.

Abstract translation: 用于促进由切片机切割的组织样品的自动或半自动收集的方法，装置和系统。 在一个示例中，收集装置可以在收集装置可操作地耦合到切片机的相应位置之间来回移动，以便收集切割的组织样本，或者提供对切片机的常规访问。 促进收集装置的相对容易的移动和定位，同时确保收集装置和切片机之间的结构稳定性和适当的对准和/或隔离。 流体储存器接收由切片机切割的样品，并且收集装置可以经由设置在储存器附近/处的储存器中的输送器状基板收集样品。 可以基于切片机的切割速度来控制基底的线性移动，并且可以自动维持储存器中的液体水平以促进有效的样品收集。

公开(公告)号：WO2012033842A3

公开(公告)日：2012-06-14

申请号：PCT/US2011050704

申请日：2011-09-07

Applicant: HARVARD COLLEGE ,  HAYWORTH KENNETH JEFFREY ,  SCHALEK RICHARD ,  TAPIA JUAN CARLOS ,  KASTHURI NARAYANAN ,  LICHTMAN JEFF

Inventor： HAYWORTH KENNETH JEFFREY ,  SCHALEK RICHARD ,  TAPIA JUAN CARLOS ,  KASTHURI NARAYANAN ,  LICHTMAN JEFF

IPC: G01N35/00 ,  G01N1/06 ,  G01N33/48

CPC classification number: G01N1/06 ,  A61B16/00 ,  G01N35/00009 ,  G01N2001/065 ,  G01N2001/066

Abstract: Methods, apparatuses and systems for facilitating automated or semi- automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.

Abstract translation: 用于促进由切片机切割的组织样品的自动或半自动收集的方法，设备和系统。 在一个示例中，收集装置可以在收集装置可操作地连接到切片机的相应位置之间来回移动，以收集切割的组织样本，或者提供对切片机的常规访问。 便于收集装置的相对容易的移动和定位，同时确保收集装置和切片机之间的结构稳定性和适当的对准和/或隔离。 流体储存器接收由切片机切割的样本，并且收集设备可以经由设置在储存器附近/中的传送带状基底来收集样本。 可以基于切片机的切割速率来控制基板的线性移动，并且可以自动保持储存器中的液位以促进有效的样品收集。