公开(公告)号：WO2007130743A2

公开(公告)日：2007-11-15

申请号：PCT/US2007063884

申请日：2007-03-13

Applicant: ARRAY BIOPHARMA INC ,  LYSSIKATOS JOSEPH P ,  WENGLOWSKY STEVEN MARK ,  HENNINGS D DAVID ,  WATSON DANIEL JOHN

Inventor： LYSSIKATOS JOSEPH P ,  WENGLOWSKY STEVEN MARK ,  HENNINGS D DAVID ,  WATSON DANIEL JOHN

IPC: A61K38/12

CPC classification number: C07K7/56 ,  A61K38/00

Abstract: The present invention relates to phenylurea derivatives of capreomycin I, IIB, IIA, or IB, and metabolites and pharmaceutically acceptable salts and solvates thereof. The compounds of the present invention are useful as antibacterial agents for treating bacterial infections and for treating disorders caused by bacterial infections. The present invention also relates to pharmaceutical compositions containing such compounds and to methods of treating bacterial infections by administering such compounds. The present invention also relates to methods of preparing such compounds.

Abstract translation: 本发明涉及卷曲霉素I，IIB，IIA或IB的苯基脲衍生物及其代谢产物及其药学上可接受的盐和溶剂化物。 本发明的化合物可用作治疗细菌感染和治疗由细菌感染引起的疾病的抗菌剂。 本发明还涉及含有这些化合物的药物组合物和通过施用这些化合物治疗细菌感染的方法。 本发明还涉及制备这些化合物的方法。