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公开(公告)号：JP2006349552A
公开(公告)日：2006-12-28
申请号：JP2005177466
申请日：2005-06-17
Applicant: HIPEP LAB , NIPPON LIGHT METAL CO
Inventor： NOKIHARA SEISHI , OKA YASUO
IPC: G01N33/53 , C12M1/00 , C12N15/09 , G01N33/543 , G01N33/547 , G01N33/548 , G01N37/00
Abstract: PROBLEM TO BE SOLVED: To provide a biochip substrate which does not cause diffusion of spots or cross contamination by contact of adjacent spots, and also to provide a biochip using it. SOLUTION: The biochip substrate comprises a plurality of recessed parts for immobilizing a biologically-relevant material formed on a substrate. According to such a structure, diffusion of spots or occurrence of cross contamination by contact of adjacent spots can be prevented. The biochip uses this substrate. COPYRIGHT: (C)2007,JPO&INPIT
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公开(公告)号：EP2306197A4
公开(公告)日：2011-08-03
申请号：EP09773454
申请日：2009-06-30
Applicant: HIPEP LAB , NIPPON LIGHT METAL CO
Inventor： NOKIHARA KIYOSHI , HIRATA AKIYOSHI , OKA YASUO , TAKEBAYASHI YASUSHI
IPC: G01N33/543 , C12N15/09 , G01N33/545 , G01N33/551 , G01N37/00
CPC classification number: G01N33/545 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00635 , B01J2219/00637 , B01L3/50 , C08J3/28 , C12Q1/6837 , G01N33/54353 , G01N33/54393 , Y10T428/273
Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
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公开(公告)号：DE60223922T2
公开(公告)日：2008-11-27
申请号：DE60223922
申请日：2002-05-07
Applicant: HIPEP LAB
Inventor： NOKIHARA KIYOSHI , MIHARA HISAKAZU
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公开(公告)号：AT380342T
公开(公告)日：2007-12-15
申请号：AT02724696
申请日：2002-05-07
Applicant: HIPEP LAB
Inventor： NOKIHARA KIYOSHI , MIHARA HISAKAZU
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Patent Agency Ranking
公开(公告)号：DE60223922D1
公开(公告)日：2008-01-17
申请号：DE60223922
申请日：2002-05-07
Applicant: HIPEP LAB
Inventor： NOKIHARA KIYOSHI , MIHARA HISAKAZU
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公开(公告)号：EP2006679A4
公开(公告)日：2009-08-05
申请号：EP06766807
申请日：2006-06-16
Applicant: HIPEP LAB , NIPPON LIGHT METAL CO
Inventor： NOKIHARA KIYOSHI , OKA YASUO
IPC: G01N33/53 , B01L3/00 , C12M1/00 , C12N15/09 , G01N33/543 , G01N33/547 , G01N37/00
CPC classification number: G01N33/54393 , B01L3/5085 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0893 , B01L2300/0896 , B01L2300/12 , B82Y30/00 , C40B60/14
Abstract: A biochip substrate which is free from cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same. A biochip substrate on which multiple valleys for immobilizing biological substances are formed so as to prevent cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same are provided. Moreover, it is found out that a desired binding in a target molecule contained in a test sample occurs at a detectable level in a solution system even in the case where a valley have such a small capacity as 1 nL to 10 nL.
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公开(公告)号：EP2168673A4
公开(公告)日：2013-12-04
申请号：EP08777189
申请日：2008-06-13
Applicant: HIPEP LAB , NIPPON LIGHT METAL CO
Inventor： NOKIHARA KIYOSHI , OKA YASUO
IPC: B01J19/00 , B01L3/00 , B81B1/00 , B81C3/00 , C07C1/32 , C07C15/12 , C07C17/26 , C07C22/08 , C07C25/22 , C07C41/30 , C07C43/225 , C12M1/00 , C12N15/09 , C40B60/02 , G01N37/00
CPC classification number: B01J19/0093 , B01J2219/00783 , B01J2219/00819 , B01J2219/00831 , B01J2219/0086 , B01J2219/00873 , B01L3/502707 , B01L2200/0689 , B01L2300/0883 , B01L2300/12 , B81B2201/051 , B81B2201/058 , B81B2203/0307 , B81C3/001 , B81C2203/0109 , B81C2203/032
Abstract: Means for overcoming the problems which the conventional glass microchannel chips have are disclosed. That is, a microchannel chip in which microchannels can be formed at a low cost, and which has a high chemical resistance is disclosed. The microchannel chip is constituted by a substrate made of carbon, which has a channel in its surface; and a cover composed of a glass plate bonded to the substrate. The cover is bonded to the substrate by heating at least a part of the contact surface at which the substrate is in contact with the cover.
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公开(公告)号：EP2407165A4
公开(公告)日：2013-06-19
申请号：EP10750900
申请日：2010-03-11
Applicant: HIPEP LAB
Inventor： NOKIHARA KIYOSHI , MIYAZATO NAEKO
IPC: A61K31/4412 , A61K8/49 , A61K8/64 , A61K36/00 , A61K38/00 , A61P9/00 , A61P17/00 , A61P17/18 , A61P35/00 , A61P39/06 , A61Q19/02
CPC classification number: A61K31/4412 , A61K8/4926 , A61K8/64 , A61K38/00 , A61K2800/522 , A61Q19/02 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0821 , C07K5/0823 , C07K5/1024
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公开(公告)号：EP1887364A4
公开(公告)日：2012-04-04
申请号：EP06756519
申请日：2006-05-24
Applicant: HIPEP LAB , NIPPON LIGHT METAL CO
Inventor： NOKIHARA KIYOSHI , OKA YASUO
IPC: G01N37/00 , B01J19/00 , B01L3/00 , C12M1/00 , C12N15/09 , G01N33/53 , G01N33/543 , G01N33/547 , G01N33/551 , G01N33/553
CPC classification number: G01N33/553 , B01J19/0046 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , G01N33/54353 , G01N33/551 , Y10T428/31678
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