公开(公告)号：JP2010155822A

公开(公告)日：2010-07-15

申请号：JP2009246503

申请日：2009-10-27

Applicant: Guey-Yueh Shi ,  Hua-Lin Wu ,  シ グエイ−ユエウ ,  ウー ヒュア−リン

Inventor： WU HUA-LIN ,  SHI GUEY-YUEH

IPC: A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/04 ,  C07K14/745 ,  C12Q1/02 ,  G01N33/66 ,  G01N33/68

CPC classification number: A61K38/366 ,  G01N33/86 ,  G01N2333/7452

Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for preventing or treating diseases resulting from Lewis Y antigen over-expression, and a method for detecting cancer cells, Gram-negative bacteria or LPS(lipopolysaccharides) which over-express the Lewis Y antigen in a sample from a subject.
SOLUTION: The pharmaceutical composition includes N-terminal lectin-like domain of thrombomodulin (TMD1) or analogues thereof. A kit including N-terminal lectin-like domain of thrombomodulin (TMD1) or labeled analogues thereof is also provided.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 待解决的问题：提供用于预防或治疗由Lewis Y抗原过表达引起的疾病的药物组合物，以及用于检测过表达Lewis的革兰氏阴性细菌或LPS（脂多糖）的方法 来自受试者的样品中的Y抗原。 解决方案：药物组合物包括血栓调节蛋白（TMD1）的N-末端凝集素样结构域或其类似物。 还提供了包括血栓调节蛋白（TMD1）的N-末端凝集素样结构域或其标记的类似物的试剂盒。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：ZA200800177B

公开(公告)日：2008-11-26

申请号：ZA200800177

申请日：2008-01-08

Applicant: CHUAN-CHI CHIANG ,  HUI-PIN SU ,  HUA-LIN WU ,  GUEY-YUEH SHI

Inventor： CHUAN-CHI CHIANG ,  HUI-PIN SU ,  HUA-LIN WU ,  GUEY-YUEH SHI

IPC: C12P20090101

公开(公告)号：US07803367B2

公开(公告)日：2010-09-28

申请号：US12316194

申请日：2008-12-10

Applicant: Hua-Lin Wu ,  Guey-Yueh Shi

Inventor： Hua-Lin Wu ,  Guey-Yueh Shi

IPC: C12N9/00

CPC classification number: A61K48/00 ,  A61K38/366

Abstract: The invention relates to a composition for promoting angiogenesis, for controlling DNA synthesis of a cell, and for controlling chemotactic motility of a cell. The invention also relates to a method for treating ischemia diseases.

Abstract translation: 本发明涉及促进血管发生的组合物，用于控制细胞的DNA合成和用于控制细胞的趋化运动性。 本发明还涉及一种治疗缺血性疾病的方法。

公开(公告)号：US20050106135A1

公开(公告)日：2005-05-19

申请号：US10938183

申请日：2004-09-10

Applicant: Hua-Lin Wu ,  Guey-Yueh Shi ,  Huey-Chun Huang

Inventor： Hua-Lin Wu ,  Guey-Yueh Shi ,  Huey-Chun Huang

IPC: A61K31/7004 ,  A61K31/737 ,  A61K38/36 ,  A61K45/06 ,  C07K14/745 ,  C07K16/36 ,  G01N33/574 ,  C12Q1/68 ,  A61K38/48 ,  C12N9/74 ,  G01N33/53 ,  G01N33/567

CPC classification number: C07K16/36 ,  A61K31/7004 ,  A61K31/737 ,  A61K38/36 ,  A61K45/06 ,  C07K14/7455 ,  C07K2317/76 ,  G01N33/574 ,  A61K2300/00

Abstract: The present invention relates to compositions, kits and treating methods for the alteration cell-cell adhesion, transport, or permeation properties of tissues. The present invention also relates to the application of drug(s) or peptide(s), compound or gene delivery, DNA or RNA(i), cosmetic or therapeutic use of the compositions and kits.

Abstract translation: 本发明涉及用于改变组织的细胞 - 细胞粘附，转运或渗透性质的组合物，试剂盒和处理方法。 本发明还涉及药物或肽，化合物或基因递送，DNA或RNA（i），组合物和试剂盒的美容或治疗用途的应用。

公开(公告)号：US09730983B2

公开(公告)日：2017-08-15

申请号：US14873880

申请日：2015-10-02

Applicant: Chih-Yuan Ma ,  Guey-Yueh Shi ,  Hua-Lin Wu

Inventor： Chih-Yuan Ma ,  Guey-Yueh Shi ,  Hua-Lin Wu

IPC: A61K38/36 ,  A61K9/00

CPC classification number: A61K38/366 ,  A61K9/0019

Abstract: A method for blocking, inhibiting and/or decreasing cluster of differentiation 14 (CD14) function, CD14-mediated cellular response and/or treating CD14-mediated pathological conditions is disclosed. The method comprises administering to a subject in need thereof a pharmaceutical composition comprising: (a) a therapeutically effective amount of a recombinant protein comprising an amino acid sequence that is at least 80% identical to SEQ ID NO: 1, wherein the recombinant protein does not comprises a lectin-like domain 1 of a human thrombomodulin; and (b) a pharmaceutically acceptable vehicle, carrier, diluent, excipients, and/or salt.

公开(公告)号：US09061000B2

公开(公告)日：2015-06-23

申请号：US13733902

申请日：2013-01-04

Applicant: Chao-Han Lai ,  Guey-Yueh Shi ,  Hua-Lin Wu

Inventor： Chao-Han Lai ,  Guey-Yueh Shi ,  Hua-Lin Wu

IPC: A61K38/36

CPC classification number: A61K38/366

Abstract: A method for pharmacological prevention and suppression of aortic aneurysm development is disclosed. The method comprises administering a therapeutically effective amount of recombinant thrombomodulin to a subject in need thereof. The recombinant thrombomodulin prevents formation and/or retards progression of an aortic aneurysm.

Abstract translation: 公开了用于药理学预防和抑制主动脉瘤发展的方法。 该方法包括向有需要的受试者施用治疗有效量的重组血栓调节素。 重组血栓调节蛋白阻止主动脉瘤的形成和/或延缓进展。

公开(公告)号：US07939567B2

公开(公告)日：2011-05-10

申请号：US11361589

申请日：2006-02-24

Applicant: Hua-Lin Wu ,  Guey-Yueh Shi

Inventor： Hua-Lin Wu ,  Guey-Yueh Shi

IPC: A01N33/02

CPC classification number: A61K31/485 ,  Y10S514/859

Abstract: The present invention relates to a method for providing bactericide or bacteriostatic, especially for treating disease due to bacterial infection. The method comprising administering a patient in need of such treatment a therapeutically effective amount of a compound of dextromethorphan or naloxone or a pharmaceutically acceptable salt or an analog thereof. The compound is applied to skin or mucosal surface of the patient. The invention also relates to a method of treating inflammation caused by suppressing secretion of TNF-α, IL-6, or MCP-1 from macrophage comprising administering a patient in need of such treatment a therapeutically effective amount of NADPH oxidase inhibitor.

Abstract translation: 本发明涉及一种提供杀菌剂或抑菌剂的方法，特别是用于治疗由细菌感染引起的疾病。 该方法包括给予需要这种治疗的患者治疗有效量的右美沙芬或纳洛酮或其药学上可接受的盐或类似物的化合物。 该化合物应用于患者的皮肤或粘膜表面。 本发明还涉及一种治疗由巨噬细胞抑制TNF-α，IL-6或MCP-1分泌引起的炎症的方法，包括给予需要这种治疗的患者治疗有效量的NADPH氧化酶抑制剂。

公开(公告)号：US07820689B2

公开(公告)日：2010-10-26

申请号：US11836159

申请日：2007-08-09

Applicant: Hua-Lin Wu ,  Guey-Yueh Shi

Inventor： Hua-Lin Wu ,  Guey-Yueh Shi

IPC: A61K31/44 ,  A61K38/00

CPC classification number: A61K31/485

Abstract: The present invention relates to a method for preventing or treating a cardiovascular disease.

Abstract translation: 本发明涉及一种预防或治疗心血管疾病的方法。

公开(公告)号：US20090118189A1

公开(公告)日：2009-05-07

申请号：US12316194

申请日：2008-12-10

Applicant: Hua-Lin Wu ,  Guey-Yueh Shi

Inventor： Hua-Lin Wu ,  Guey-Yueh Shi

IPC: A61K38/16

CPC classification number: A61K48/00 ,  A61K38/366

Abstract: The invention relates to a composition for promoting angiogenesis, for controlling DNA synthesis of a cell, and for controlling chemotactic motility of a cell. The invention also relates to a method for treating ischemia diseases.

Abstract translation: 本发明涉及促进血管发生的组合物，用于控制细胞的DNA合成和用于控制细胞的趋化运动性。 本发明还涉及一种治疗缺血性疾病的方法。

公开(公告)号：US5876999A

公开(公告)日：1999-03-02

申请号：US568393

申请日：1995-12-06

Applicant: Hua-Lin Wu

Inventor： Hua-Lin Wu

IPC: A61K38/00 ,  C07K14/315 ,  C12N9/70 ,  C12N1/20 ,  C12N15/00 ,  C12P21/06

CPC classification number: C07K14/3153 ,  A61K38/00

Abstract: Mutants of streptokinase in which one or more amino acid residues in the region of Pro58-Lys59-Ser60-Lys61 were replaced by other amino acids become better fibrinolytic agents. The mutants are resistant to the hydrolytic inactivation by plasmin and are more efficient in inducing fibrinolysis of plasma clots.

Abstract translation: 其中Pro58-Lys59-Ser60-Lys61区域中的一个或多个氨基酸残基被其它氨基酸替代的链激酶突变体变成更好的纤维蛋白溶解剂。 突变体对纤溶酶的水解失活具有抗性，并且更有效地诱导血浆凝块的纤维蛋白溶解。