公开(公告)号：AU9106301A

公开(公告)日：2002-03-26

申请号：AU9106301

申请日：2001-09-11

Applicant: UNIV CALIFORNIA ,  CHIEN KENNETH R ,  HOSHIJIMA MASAHIKO ,  ROSS JOHN ,  IKEDA YASUHIRO

Inventor： CHIEN KENNETH R ,  HOSHIJIMA MASAHIKO ,  ROSS JOHN ,  IKEDA YASUHIRO

IPC: A61K38/17 ,  A61K38/46 ,  A61K48/00 ,  A61P9/00 ,  C12N15/12

Abstract: Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are described. The method results in high-level, long-term expression of reporter genes and enhanced cardiac function in hamster models of heart disease.

公开(公告)号：EP3488001A1

公开(公告)日：2019-05-29

申请号：EP17835040.1

申请日：2017-07-24

Applicant: Mayo Foundation for Medical Education and Research ,  Ikeda, Yasuhiro ,  Machida, Yuichi ,  Tonne, Jason, M. ,  Morsy, Salma, G.

Inventor： IKEDA, Yasuhiro ,  MACHIDA, Yuichi ,  TONNE, Jason, M. ,  MORSY, Salma, G.

IPC: C12N15/09 ,  C12N15/10 ,  C12Q1/68

公开(公告)号：EP1317289A2

公开(公告)日：2003-06-11

申请号：EP01971139.9

申请日：2001-09-11

Applicant: The Regents of the University of California ,  Chien, Kenneth R. ,  Hoshijima, Masahiko ,  Ross, John, Jr. ,  Ikeda, Yasuhiro

Inventor： CHIEN, Kenneth, R. ,  HOSHIJIMA, Masahiko ,  ROSS, John, Jr. ,  IKEDA, Yasuhiro,Yamaguchi Univ. Sch. of Med.

IPC: A61K48/00

CPC classification number: A61K38/1709 ,  A61K31/4045 ,  A61K31/417 ,  A61K38/046 ,  A61K38/177 ,  A61K38/1787 ,  A61K38/46 ,  A61K45/06 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/0083 ,  C12N2710/10043 ,  C12N2750/14143 ,  A61K2300/00

Abstract: Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are described. The method results in high-level, long-term expression of reporter genes and enhanced cardiac function in hamster models of heart disease.

公开(公告)号：WO2010017562A3

公开(公告)日：2010-04-22

申请号：PCT/US2009053314

申请日：2009-08-10

Applicant: MAYO FOUNDATION ,  IKEDA YASUHIRO ,  TERZIC ANDRE ,  NELSON TIMOTHY J ,  MAEL AMBER A ,  FERNANDEZ ALMUDENA J MARTINEZ ,  YAMADA SATSUKI

Inventor： IKEDA YASUHIRO ,  TERZIC ANDRE ,  NELSON TIMOTHY J ,  MAEL AMBER A ,  FERNANDEZ ALMUDENA J MARTINEZ ,  YAMADA SATSUKI

IPC: C12N5/074 ,  C12N5/10 ,  C12N15/12

CPC classification number: C12N5/0696 ,  A61K35/12 ,  C12N2500/90 ,  C12N2500/98 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2510/00 ,  C12N2740/16043

Abstract: This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.

Abstract translation: 本文件提供了与诱导性多能干细胞有关的方法和材料。 例如，提供了诱导性多能干细胞，含有诱导性多能干细胞的组合物，获得诱导性多能干细胞的方法以及使用诱导性多能干细胞的方法。 此外，提供了使用诱导性多能干细胞体内修复组织（例如心血管组织）的方法和材料，以及使用诱导性多能干细胞评估其在合适的动物模型中的治疗潜力的方法和材料。

公开(公告)号：WO2015192063A1

公开(公告)日：2015-12-17

申请号：PCT/US2015/035639

申请日：2015-06-12

Applicant: IKEDA, Yasuhiro ,  SCHREIBER, Claire A. ,  SAKUMA, Toshie ,  HOLDITCH, Sara J. ,  KOIDE, Kazunori

Inventor： IKEDA, Yasuhiro ,  SCHREIBER, Claire A. ,  SAKUMA, Toshie ,  HOLDITCH, Sara J. ,  KOIDE, Kazunori

IPC: A61K38/02 ,  A61K35/76 ,  A61K48/00

CPC classification number: A61K48/00 ,  A61K31/5377 ,  A61K38/00 ,  A61K48/0083 ,  C12N15/86 ,  C12N2750/14143

Abstract: This document relates to methods and materials for increasing viral vector infectivity. For example, methods and materials for using spliceosome inhibitors (e.g., U2 snRNP spliceosome inhibitors such as meayamycin B or pladienolide derivative E7107) to increase viral vector (e.g., adeno-associated virus-based vector) infectivity are provided.

Abstract translation: 本文件涉及增加病毒载体感染性的方法和材料。 例如，提供了用于使用剪接体抑制剂（例如，U2 snRNP剪接体抑制剂如美洛霉素B或普拉德内酯衍生物E7107）来增加病毒载体（例如，腺相关病毒载体）感染性的方法和材料。

公开(公告)号：WO2013171790A1

公开(公告)日：2013-11-21

申请号：PCT/JP2012/003188

申请日：2012-05-16

Applicant: HITACHI, LTD. ,  IKEDA, Yasuhiro ,  UEMATSU, Yutaka ,  MURAOKA, Satoshi

Inventor： IKEDA, Yasuhiro ,  UEMATSU, Yutaka ,  MURAOKA, Satoshi

IPC: G11C7/10

CPC classification number: G11C7/10 ,  G11C7/1057 ,  G11C7/1084

Abstract: To suppress power consumption and enhance signal quality as compared with the case where first and second semiconductor elements are terminated only by on-chip input termination resistor circuits. A first semiconductor element with a switching function and a second semiconductor element with a switching function are connected to each other with a substrate interconnection, and a resistor element is connected in parallel with the substrate interconnection. The resistor element is placed at an arbitrary position or a branch point on the signal interconnection.

Abstract translation: 与第一和第二半导体元件仅由片上输入终端电阻电路端接的情况相比，抑制功耗和提高信号质量。 具有开关功能的第一半导体元件和具有开关功能的第二半导体元件通过衬底互连彼此连接，并且电阻元件与衬底互连并联连接。 电阻元件放置在信号互连的任意位置或分支点处。

公开(公告)号：WO2010017562A2

公开(公告)日：2010-02-11

申请号：PCT/US2009/053314

申请日：2009-08-10

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  IKEDA, Yasuhiro ,  TERZIC, Andre ,  NELSON, Timothy, J. ,  MAEL, Amber, A. ,  FERNANDEZ, Almudena, J. Martinez ,  YAMADA, Satsuki

Inventor： IKEDA, Yasuhiro ,  TERZIC, Andre ,  NELSON, Timothy, J. ,  MAEL, Amber, A. ,  FERNANDEZ, Almudena, J. Martinez ,  YAMADA, Satsuki

IPC: C12N5/074 ,  C12N5/10 ,  C12N15/12

CPC classification number: C12N5/0696 ,  A61K35/12 ,  C12N2500/90 ,  C12N2500/98 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2510/00 ,  C12N2740/16043

Abstract: This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.

Abstract translation: 本文提供了与诱导多能干细胞相关的方法和材料。 例如，提供诱导多能干细胞，含有诱导多能干细胞的组合物，获得诱导多能干细胞的方法，以及使用诱导性多能干细胞的方法。 此外，提供了使用诱导性多能干细胞修复体内组织（例如心血管组织）的方法和材料以及用于使用诱导性多能干细胞评价其在适当动物模型中的治疗潜力的方法和材料。

公开(公告)号：WO2002022177A3

公开(公告)日：2002-03-21

申请号：PCT/US2001/029103

申请日：2001-09-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  CHIEN, Kenneth, R. ,  HOSHIJIMA, Masahiko ,  ROSS, John, Jr. ,  IKEDA, Yasuhiro

Inventor： CHIEN, Kenneth, R. ,  HOSHIJIMA, Masahiko ,  ROSS, John, Jr. ,  IKEDA, Yasuhiro

IPC: C12N15/12

Abstract: Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are described. The method results in high-level, long-term expression of reporter genes and enhanced cardiac function in hamster models of heart disease.

公开(公告)号：WO2018022480A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/043452

申请日：2017-07-24

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  IKEDA, Yasuhiro ,  MACHIDA, Yuichi ,  TONNE, Jason, M. ,  MORSY, Salma, G.

Inventor： IKEDA, Yasuhiro ,  MACHIDA, Yuichi ,  TONNE, Jason, M. ,  MORSY, Salma, G.

IPC: C12N15/09 ,  C12N15/10 ,  C12Q1/68

Abstract: This document relates to methods and materials for treating cancer. For example, methods and materials for using CRISPR/Cas9 systems to treat cancer are provided.

Abstract translation: 本文件涉及治疗癌症的方法和材料。 例如，提供了使用CRISPR / Cas9系统治疗癌症的方法和材料。

公开(公告)号：WO2016077143A1

公开(公告)日：2016-05-19

申请号：PCT/US2015/059208

申请日：2015-11-05

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  IKEDA, Yasuhiro ,  HOLDITCH, Sara J. ,  CATALIOTTI, Alessandro ,  TORRES, Vincente E.

Inventor： IKEDA, Yasuhiro ,  HOLDITCH, Sara J. ,  CATALIOTTI, Alessandro ,  TORRES, Vincente E.

IPC: C07K14/58

CPC classification number: A61K38/22 ,  C07K14/58

Abstract: This document provides methods and materials for using natriuretic polypeptides to reduce the generation of kidney cysts, to reduce the number of kidney cysts, to reduce the size of kidney cysts, and/or to reduce the weight of a mammal's kidneys in mammals with polycystic kidney disease. For example, methods and materials for using natriuretic polypeptides (e.g., BNP) and/or nucleic acid encoding natriuretic polypeptides to reduce kidney cystogenesis and to reduce kidney organ to body weight ratios in mammals with mammals with polycystic kidney disease (e.g., autosomal recessive polycystic kidney disease) are provided.

Abstract translation: 本文件提供了使用利钠多肽减少肾囊肿的产生，减少肾囊肿数量，减少肾囊肿的大小和/或降低哺乳动物肾脏与多囊肾的重量的方法和材料 疾病。 例如，使用利尿钠多肽（例如BNP）和/或编码利尿钠多肽的核酸以减少肾囊肿发生并减少哺乳动物与多囊肾病（例如常染色体隐性多囊卵巢）的肾脏器官与体重比的方法和材料 肾脏疾病）。