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    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS
    1.
    发明申请
    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS 审中-公开
    用于生物和化学分析的集成传感器阵列

    公开(公告)号：WO2010047804A1

    公开(公告)日：2010-04-29

    申请号：PCT/US2009005745

    申请日：2009-10-22

    Applicant: ION TORRENT SYSTEMS INC ,  ROTHBERG JONATHAN M ,  SCHULTZ JONATHAN C ,  JOHNSON KIM L ,  REARICK TODD M ,  MILGREM MARK JAMES ,  MARRAN DAVID ,  BUSTILLO JAMES M

    Inventor： ROTHBERG JONATHAN M ,  SCHULTZ JONATHAN C ,  JOHNSON KIM L ,  REARICK TODD M ,  MILGREM MARK JAMES ,  MARRAN DAVID ,  BUSTILLO JAMES M

    IPC: G01N27/416 ,  C12M1/34

    CPC classification number: G01N27/4145

    Abstract: The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 µm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.

    Abstract translation: 本发明涉及包括大规模化学场效应晶体管阵列的装置和芯片，其包括能够保留来自样品流体的化学或生物样品用于分析的样品保持区阵列。 在一个方面，这种晶体管阵列具有10μm或更小的间距，并且每个采样保持区域位于至少一个化学场效应晶体管上，该晶体管被配置为产生与化学或生物样品的特性相关的至少一个输出信号 在这样的样品保留区域中。 在一个实施方案中，所述化学或生物样品的特征是带电物质的浓度，并且其中每个所述化学场效应晶体管是离子敏感场效应晶体管，其具有在其表面上具有介电层的浮置栅极， 电介质层与所述样品流体接触并且能够与所述样品流体中的带电物质的浓度成比例地积累电荷。 在一个实施方案中，这种带电物质是氢离子，使得传感器测量样品流体在其样品保持区域中或其附近的pH值的变化。 本发明的装置和芯片可适用于大规模的基于pH的DNA测序和其他生物科学和生物医学应用。

    METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS
    3.
    发明申请
    METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS 审中-公开
    使用FET阵列检测分子相互作用的方法和装置

    公开(公告)号：WO2009158006A3

    公开(公告)日：2010-05-06

    申请号：PCT/US2009003797

    申请日：2009-06-26

    Applicant: ION TORRENT SYSTEMS INC ,  ROTHBERG JONATHAN M

    Inventor： ROTHBERG JONATHAN M

    IPC: G01N27/414 ,  C12Q1/68 ,  G01N27/416 ,  H01L29/06 ,  H01L29/786

    CPC classification number: G01N27/4145 ,  G01N27/4148

    Abstract: Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes.

    Abstract translation: 提供了与用于分析物检测和测量的大规模FET阵列相关的方法和装置。 可以使用基于提高测量灵敏度和精度的改进的FET像素和阵列设计的传统CMOS处理技术来制造ChemFET（例如，ISFET）阵列，并且同时促进显着小的像素尺寸和致密阵列。 改进的阵列控制技术提供了从大型和密集阵列的快速数据采集。 可以使用这样的阵列来检测各种化学和/或生物过程中各种分析物类型的存在和/或浓度变化。

    Methods and apparatus for measuring analytes using large scale fet arrays
    8.
    发明专利
    Methods and apparatus for measuring analytes using large scale fet arrays 未知

    公开(公告)号：GB2457851A

    公开(公告)日：2009-09-02

    申请号：GB0911039

    申请日：2007-12-14

    Applicant: ION TORRENT SYSTEMS INC

    Inventor： HINZ WOLFGANG ,  ROTHBERG JONATHAN ,  JOHNSON KIM ,  BUSTILLO JAMES

    IPC: G01N27/414 ,  G01N33/543

    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense rays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biologlcal processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

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