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    Optical fiber exploration micro-slide, micro slide kit, and the use thereof
    3.
    发明专利
    Optical fiber exploration micro-slide, micro slide kit, and the use thereof 审中-公开

    公开(公告)号：JP2009515192A

    公开(公告)日：2009-04-09

    申请号：JP2008540174

    申请日：2006-11-08

    Applicant: インコム,インコーポレイテッドIncom,Inc.

    Inventor： ストウ，デイビッド，ダブリュー． ,  マイノット，マイケル，ジェー．

    IPC: G01N21/03 ,  G01N21/76 ,  G01N33/53 ,  G01N33/543 ,  G01N35/02 ,  G01N37/00

    CPC classification number: G02B21/34 ,  G02B6/06

    Abstract: 本発明は、基板の厚み通して光学的に探査する際、従来の顕微鏡スライド、マイクロアレイ、またはマイクロタイタープレートの性能限界を克服する基板を提供する。 従来の顕微鏡スライドでは、ガラスの厚みを通した画像化により導入される歪みの結果として、画質および解像度が悪化する。 光ファイバ探査型マイクロスライド（ＦＯＩ）は、共に融合されている多くの光ファイバからなる。 顕微鏡スライドを形成するためスライスし研磨したとき、ファイバはマイクロスライドの片面から他面へと、光画像を効率的に移行する。 完成したマイクロスライドは、厚みゼロのウィンドウに相当する光量である。 上面にある対象物の画像は、スライドの厚みを通して焦点を合わせることなく、観察することが可能な底部表面に移行する。 改善された画質の提供に加え、ＦＯＩマイクロスライドにより、複合的で高価な集束レンズなしで、対象物を直接画像化することができる。
    【選択図】図１２

    GLASS STRUCTURES AND FABRICATION METHODS USING LASER INDUCED DEEP ETCHING
    6.
    发明申请
    GLASS STRUCTURES AND FABRICATION METHODS USING LASER INDUCED DEEP ETCHING 有权

    公开(公告)号：US20220267200A1

    公开(公告)日：2022-08-25

    申请号：US17677082

    申请日：2022-02-22

    Applicant: Incom, Inc.

    Inventor： Michael J. Minot ,  Alexey Lyashenko ,  Michael A. Detarando ,  Till Cremer ,  Cole J. Hamel ,  Mark A. Popecki

    IPC: C03C17/36

    Abstract: A method of making a functionalized device for amplification or multiplication of electrons includes making a glass channel array by a laser-induced deep etching process including (1) applying laser pulses to a glass substrate to form an array of modified areas, the glass substrate having a thickness less than 5 mm, the modified areas extending between two surfaces of the glass substrate, and (2) subsequently performing an etching process to selectively remove the modified areas and thereby form an array of through channels. Subsequently, one or more materials are deposited on the glass channel array to form the functionalized device.

    PROTON RADIOGRAPHY SYSTEM INCORPORATING TIME-OF-FLIGHT MEASUREMENT
    7.
    发明申请
    PROTON RADIOGRAPHY SYSTEM INCORPORATING TIME-OF-FLIGHT MEASUREMENT 审中-公开

    公开(公告)号：US20170258421A1

    公开(公告)日：2017-09-14

    申请号：US15456795

    申请日：2017-03-13

    Applicant: Incom, Inc.

    Inventor： William Alan Worstell

    IPC: A61B6/00 ,  A61B6/03 ,  A61N5/10

    CPC classification number: A61B6/032 ,  A61B6/4071 ,  A61B6/4258 ,  A61N5/10 ,  A61N5/103 ,  A61N5/1071 ,  A61N2005/1087

    Abstract: A proton radiography system includes a source of a proton beam at nonrelativistic energy, directed on a beam path to an object to be imaged; one or more time-of-flight (TOF) detectors arranged on the beam path to detect incidence of beam protons and generate output signals indicative thereof with a time resolution substantially less than a time of flight of the protons; and a data acquisition and analysis subsystem coupled to the TOF detectors to receive the respective output signals and (1) calculate TOF values for respective bunches of one or more protons, (2) convert the TOF values to proton velocity values and proton energy values, and (3) use the proton energy values to calculate a corresponding value for a physical property of the object along the beam path, and incorporate the value into elements of a radiographic image of the object stored or displayed in the system.

    FORMING POLYMER OPTICAL DEVICES BY MOLD-CONSTRAINED RELAXATION EXPANSION
    8.
    发明申请
    FORMING POLYMER OPTICAL DEVICES BY MOLD-CONSTRAINED RELAXATION EXPANSION 审中-公开

    公开(公告)号：WO2019246337A1

    公开(公告)日：2019-12-26

    申请号：PCT/US2019/038122

    申请日：2019-06-20

    Applicant: INCOM, INC.

    Inventor： WELKER, David James ,  NARDONE, Kenneth Christopher ,  DEBLANDER, Evan Franklin ,  DAVIDSON, Eric Robert

    IPC: B29D11/00 ,  G02B6/255 ,  G02B1/04

    Abstract: A method of making a waveguiding optical component includes processing a polymer optical material to form a billet having an axis of light transmission and having residual stress maintaining a transverse extent of the billet; placing the billet into a mold, the mold being configured to constrain transverse expansion of the billet according to a desired shape of the waveguiding optical component; and heating the billet in the mold to induce relaxation of the residual stress and corresponding transverse expansion of the billet, thereby forming the billet into the waveguiding optical component with the desired shape. An alternative method begins with a collection of individual canes or fiber segments which are fused during the heating process, bypassing a separate process of forming a billet.

    FIBER OPTIC INTERROGATED MICROFLUIDIC DEVICE
    9.
    发明申请
    FIBER OPTIC INTERROGATED MICROFLUIDIC DEVICE 审中-公开

    公开(公告)号：WO2005069971A3

    公开(公告)日：2005-08-04

    申请号：PCT/US2005/002087

    申请日：2005-01-24

    Applicant: INCOM, INC. ,  MINOT, Michael, J. ,  DETARANDO, Michael, A. ,  KASS, Jason

    Inventor： MINOT, Michael, J. ,  DETARANDO, Michael, A. ,  KASS, Jason

    IPC: G02B6/26

    Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. The device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. The plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include, without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.

    FIBER OPTIC INTERROGATED MICROFLUIDIC DEVICE
    10.
    发明申请
    FIBER OPTIC INTERROGATED MICROFLUIDIC DEVICE 审中-公开
    光纤光学微流体器件

    公开(公告)号：WO2005069971B1

    公开(公告)日：2007-02-01

    申请号：PCT/US2005002087

    申请日：2005-01-24

    Applicant: INCOM INC ,  MINOT MICHAEL J ,  DETARANDO MICHAEL A ,  KASS JASON

    Inventor： MINOT MICHAEL J ,  DETARANDO MICHAEL A ,  KASS JASON

    IPC: G02B6/26 ,  B01L3/00 ,  G01N21/03 ,  G01N21/25 ,  G02B6/08

    CPC classification number: G02B6/08 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/02 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  G01N21/03 ,  G01N21/253 ,  G01N2021/0346 ,  G01N2201/0833

    Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. The device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. The plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include, without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.

    Abstract translation: 本发明提供了可用于多个样品的光纤询问的微流体装置。 该装置包括整体地包括多个光纤的基板。 形成在衬底的表面上的层限定了与至少一个光纤通信的至少一个拓扑特征，用于询问样品。 该装置优选地包括多个拓扑特征，其可以包括井的图案化阵列，通道或其任何组合。 本发明的装置的多个光纤能够同时询问数千个样品。 这些样品可以包括但不限于分子，细胞，蛋白质组学，基因组或气体材料或测定。 本发明还公开了一种用于制造微流体装置的方法。 本发明还包括通过本文提供的微流体装置并行询问多个样品的方法。

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