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    MODULATION OF TISSUE TRANSGLUTAMINASE ACTIVATION IN DISEASE
    4.
    发明申请
    MODULATION OF TISSUE TRANSGLUTAMINASE ACTIVATION IN DISEASE 审中-公开
    组织转移蛋白酶激活在疾病中的调节

    公开(公告)号：WO2012177640A2

    公开(公告)日：2012-12-27

    申请号：PCT/US2012043150

    申请日：2012-06-19

    Applicant: UNIV LELAND STANFORD JUNIOR ,  DIRAIMONDO THOMAS ,  JIN XI ,  KLOECK CORNELIUS ,  KHOSLA CHAITAN

    Inventor： DIRAIMONDO THOMAS ,  JIN XI ,  KLOECK CORNELIUS ,  KHOSLA CHAITAN

    IPC: A61K31/47

    CPC classification number: A61K31/5377 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/473

    Abstract: Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activation of TG2 associated with enteric inflammatory disorders, which disorders may include celiac disease, irritable bowel syndrome, Crohn's Disease, dermatitis herpetiformis, and the like. In other embodiments of the invention, methods are provided for reducing undesirable paracellular transport in enteric tissues, in particular the paracellular transport of molecules greater than about 500 mw, e.g. peptides, including without limitation immunogenic gluten peptides.

    Abstract translation: 提供组成和方法用于调节组织转谷氨酰胺酶（TG2）的生理活化; 哪些方法可以包括抑制与肠炎性疾病相关的TG2的活化，该疾病可包括乳糜泻，肠易激综合征，克罗恩病，疱疹样疱疹等。 在本发明的其它实施方案中，提供了用于减少肠组织中不想要的细胞旁转运的方法，特别是大于约500mw的分子的细胞旁转运，例如， 肽，包括但不限于免疫原性谷蛋白肽。

    MODULATION OF TISSUE TRANSGLUTAMINASE ACTIVATION IN DISEASE
    5.
    发明申请
    MODULATION OF TISSUE TRANSGLUTAMINASE ACTIVATION IN DISEASE 审中-公开
    组织转移蛋白酶激活在疾病中的调节

    公开(公告)号：WO2012177640A8

    公开(公告)日：2014-01-30

    申请号：PCT/US2012043150

    申请日：2012-06-19

    Applicant: UNIV LELAND STANFORD JUNIOR ,  DIRAIMONDO THOMAS ,  JIN XI ,  KLOECK CORNELIUS ,  KHOSLA CHAITAN

    Inventor： DIRAIMONDO THOMAS ,  JIN XI ,  KLOECK CORNELIUS ,  KHOSLA CHAITAN

    IPC: C12Q1/52 ,  C12N5/00 ,  G01N33/573

    CPC classification number: A61K31/5377 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/473

    Abstract: Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activation of TG2 associated with enteric inflammatory disorders, which disorders may include celiac disease, irritable bowel syndrome, Crohn's Disease, dermatitis herpetiformis, and the like. In other embodiments of the invention, methods are provided for reducing undesirable paracellular transport in enteric tissues, in particular the paracellular transport of molecules greater than about 500 mw, e.g. peptides, including without limitation immunogenic gluten peptides.

    Abstract translation: 提供组成和方法用于调节组织转谷氨酰胺酶（TG2）的生理活化; 哪些方法可以包括抑制与肠炎性疾病相关的TG2的活化，所述疾病可包括乳糜泻，肠易激综合征，克罗恩病，疱疹样疱疹等。 在本发明的其它实施方案中，提供了用于减少肠组织中不期望的细胞旁转运的方法，特别是大于约500mw的分子的细胞旁转运，例如， 肽，包括但不限于免疫原性谷蛋白肽。

    Oral care implement
    7.
    发明授权
    Oral care implement 有权
    口腔护理器具

    公开(公告)号：US09167887B2

    公开(公告)日：2015-10-27

    申请号：US13997023

    申请日：2010-12-21

    Applicant: Wen Jin Xi ,  Yu Liu ,  Jian Rong Zhou

    Inventor： Wen Jin Xi ,  Yu Liu ,  Jian Rong Zhou

    IPC: A46B7/06 ,  A46B9/04 ,  A46B9/06 ,  A46B15/00 ,  A46B5/00 ,  A46D3/00 ,  A61B17/24

    CPC classification number: A46B9/04 ,  A46B5/0029 ,  A46B7/06 ,  A46B9/06 ,  A46B15/0075 ,  A46B15/0081 ,  A46B2200/1026 ,  A46B2200/1066 ,  A46D3/00 ,  A61B17/244

    Abstract: An oral care implement, such as a toothbrush (100), comprises a handle (110) and a head (120). A plurality of tooth cleaning elements (130) may be provided on a front surface (121) of the head (120). The head (120) is formed by a plurality of spaced-apart segments (140-145) made of a rigid material. The segments (140-145) are isolated from one another by channels (157-159B) containing an elastomeric material (146) that flexibly connects the segments (140-145) together. The oral care implement further comprises an elastomeric soft tissue cleaner (200) located on a rear surface (122) of the head (120) opposite the front surface (121) of the head (120). Each of the segments (140-145) comprises a protuberance (163-169) made of the rigid material that extends through the elastomeric soft tissue cleaner (200) and is exposed therethrough.

    Abstract translation: 诸如牙刷（100）的口腔护理器具包括手柄（110）和头部（120）。 可以在头部（120）的前表面（121）上设置多个牙齿清洁元件（130）。 头部（120）由多个由刚性材料制成的间隔开的部分（140-145）形成。 通过包含将片段（140-145）柔性连接在一起的弹性体材料（146）的通道（157-159B）彼此隔开的片段（140-145）。 口腔护理器具还包括位于与头部（120）的前表面（121）相对的头部（120）的后表面（122）上的弹性软组织清洁器（200）。 每个段（140-145）包括由刚性材料制成的突起（163-169），其延伸穿过弹性软组织清洁器（200）并暴露在其中。

    Oral care implement
    8.
    发明授权
    Oral care implement 有权
    口腔护理器具

    公开(公告)号：US08959696B2

    公开(公告)日：2015-02-24

    申请号：US13992268

    申请日：2010-12-21

    Applicant: Wen Jin Xi ,  Liu Yu ,  Jian Rong Zhou

    Inventor： Wen Jin Xi ,  Liu Yu ,  Jian Rong Zhou

    IPC: A46B7/06 ,  A46B9/04 ,  A61C17/00 ,  A46B5/00 ,  A46B9/06

    CPC classification number: A46B9/04 ,  A46B5/0029 ,  A46B7/06 ,  A46B9/06 ,  A61C17/00 ,  Y10S15/06

    Abstract: An oral care implement, such as a toothbrush. In one aspect, the invention is an oral care implement comprising a handle and a head. A plurality of tooth cleaning elements may extend from a front surface of the head, which is formed by a plurality of spaced-apart segments formed of a rigid material, wherein the plurality of segments include a cruciform segment integrally formed with and extending from a distal end of the handle, a first pair of segments located on opposite sides of a longitudinal portion of the cruciform segment, and a second pair of segments located on opposite sides of the longitudinal portion of the cruciform segment, the first pair of segments located on an opposite side of a transverse portion of the cruciform segment from the second pair of segments. The segments of the first and second pairs are flexibly connected to the cruciform segment.

    Abstract translation: 口腔护理器具，如牙刷。 一方面，本发明是一种包括手柄和头部的口腔护理器具。 多个牙齿清洁元件可以从头部的前表面延伸，头部的前表面由由刚性材料形成的多个间隔开的段形成，其中多个段包括十字形段，该十字形段与远端 手柄的端部，位于十字形段的纵向部分的相对侧上的第一对片段和位于十字形片段的纵向部分的相对侧上的第二对片段，第一对片段位于 十字形段与第二对分段的横向部分的相对侧。 第一和第二对的段被柔性地连接到十字形段。

    Method for acquiring information of home node B, method for balancing load, and apparatuses therefor
    9.
    发明授权
    Method for acquiring information of home node B, method for balancing load, and apparatuses therefor 有权
    用于获取家庭节点B的信息的方法，用于平衡负载的方法及其装置

    公开(公告)号：US08855664B2

    公开(公告)日：2014-10-07

    申请号：US13634571

    申请日：2010-09-02

    Applicant: Yin Gao ,  Zhongming Chen ,  Jin Xi

    Inventor： Yin Gao ,  Zhongming Chen ,  Jin Xi

    IPC: H04W72/00 ,  H04W36/22 ,  H04W36/30 ,  H04W36/00

    CPC classification number: H04W36/30 ,  H04W28/08 ,  H04W36/0061 ,  H04W36/0072 ,  H04W36/0077 ,  H04W36/04 ,  H04W36/22

    Abstract: The present invention discloses a method for acquiring information of a home NodeB, a method for balancing load, and implementation apparatuses thereof, which are used to solve the problem how to guide a UE to move to an appropriate home NodeB when a macro cell performs load balancing. In the present invention, information of a target NodeB is acquired actively through a macro NodeB, and according to an access type of the target NodeB, subscribers of the macro NodeB are timely balanced to the home NodeB which can provide services, thereby reducing a call drop rate resulted from blind handover. Since measurement information of the UE is fully considered, success rate of balancing handover is enhanced, and the object of performing effective load balancing in a home NodeB environment is achieved.

    Abstract translation: 本发明公开了一种用于获取家庭节点B的信息的方法，负载平衡方法及其实现装置，其用于解决当宏小区执行负载时如何引导UE移动到适当的家庭基站B的问题 平衡 在本发明中，通过宏节点B主动地获取目标节点B的信息，根据目标节点B的接入类型，将宏节点B的用户及时平衡到能够提供业务的家庭基站B，从而减少呼叫 丢失率是由盲目移交造成的。 由于充分考虑了UE的测量信息，因此平衡切换的成功率得到提高，并且在家庭NodeB环境中实现有效的负载平衡的目的。

    Method and system for implementing direct interface between access network nodes
    10.
    发明申请
    Method and system for implementing direct interface between access network nodes 有权

    公开(公告)号：US20130064092A1

    公开(公告)日：2013-03-14

    申请号：US13697600

    申请日：2011-03-18

    Applicant: Jin Xi ,  Shengming Wang ,  Feng He

    Inventor： Jin Xi ,  Shengming Wang ,  Feng He

    IPC: H04W92/06 ,  H04W28/08 ,  H04W36/06

    CPC classification number: H04W92/20

    Abstract: The disclosure provides a method and a system for implementing a direct interface between access network nodes. The method includes: establishing, by an access network node, a direct interface with a proxy node (300); exchanging, by the access network node, information with an access network node managed by the proxy node through the established direct interface (301). By establishing a direct interface between access network nodes and performing a direct interface flow through a proxy node, the disclosure simplifies the establishment and maintenance of the direct interface on the premise that the handover speed is increased and the signaling load of a core network is decreased, thereby reducing the complexity of the establishment and maintenance of the direct interface.

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