公开(公告)号：CA2957771A1

公开(公告)日：2018-08-13

申请号：CA2957771

申请日：2017-02-13

Applicant: STROHM ERIC M ,  MOORE MICHAEL J ,  KOLIOS MICHAEL C

Inventor： STROHM ERIC M ,  MOORE MICHAEL J ,  KOLIOS MICHAEL C

IPC: G01N21/17 ,  G01N29/14

Abstract: There is provided a method for sensing a sample. The method includes the following steps: first a light beam is directed onto the sample. The sample transmits at least a portion of the light beam to form a transmitted light beam. Next, the transmitted light beam is received at an acoustic transducer. The acoustic transducer absorbs at least a portion of the transmitted light beam and in response generated an acoustic wave. Subsequently, an electrical signal is generated at the acoustic transducer. The electrical signal is generated based on at least a portion of the acoustic wave.

公开(公告)号：CA2902122A1

公开(公告)日：2016-03-01

申请号：CA2902122

申请日：2015-08-31

Applicant: XU YUAN ,  KOLIOS MICHAEL C ,  GONG PING ,  LI YING

Inventor： XU YUAN ,  KOLIOS MICHAEL C ,  GONG PING ,  LI YING

IPC: G01S13/90

Abstract: The invention generally relates to the field of synthetic aperture imaging. In particular, the invention relates to systems and methods for generating synthetic transmit aperture ("STA") signals and processing synthetic aperture imaging ("SAI") signals for improved signal-to-noise ratio ("SNR") and spatial resolution. This generally relates to a method to improve the signal-noise-ratio (SNR) of array signals by both encoding the transmission from multiple array elements with waveform modifications and time delays and encoding the receivers into output channels and decoding the measured signals at the selected output channels to estimate the equivalent received signals of a receiver as if only one transmitting element were fired individually in each transmission event. SAI techniques are subsequently applied to the equivalent SAI signals to obtain improved images.

公开(公告)号：WO2021127784A1

公开(公告)日：2021-07-01

申请号：PCT/CA2020/051791

申请日：2020-12-23

Applicant: UNITY HEALTH TORONTO ,  HYSI, Eno ,  KOLIOS, Michael C.

Inventor： YUEN, Darren A.

IPC: A61B8/00 ,  A61B8/13

Abstract: Various embodiments are described herein for a system and associated method for performing collagen assessment of an object using Photoacoustic Image (PA) data obtained for the object, wherein the method is performed by a processing unit and the method comprises: obtaining beamformed PA image data for the object using at least three wavelengths related to chromophores including collagen, oxyhemoglobin and deoxyhemoglobin, the three wavelengths being less than 1000 nm; performing spectral decomposition on the beamformed PA image data using the three wavelengths to obtain data that is used for generating at least one collagen map; and determining a collagen score for the at least one collagen map.

公开(公告)号：WO0011468A3

公开(公告)日：2000-06-02

申请号：PCT/CA9900770

申请日：1999-08-19

Applicant: ONTARIO CANCER INST ,  SHERAR MICHAEL D ,  CZARNOTA GREGORY J ,  HUNT JOHN W ,  KOLIOS MICHAEL C

Inventor： SHERAR MICHAEL D ,  CZARNOTA GREGORY J ,  HUNT JOHN W ,  KOLIOS MICHAEL C

IPC: A61B8/08 ,  G01N29/06 ,  G01N29/46 ,  G01S7/52 ,  G01S15/89 ,  A61B8/13

CPC classification number: G01S7/52036 ,  A61B8/08 ,  G01N29/0672 ,  G01N29/46 ,  G01N2291/02854 ,  G01S15/895 ,  G01S15/8956

Abstract: A non-invasive method of monitoring apoptosis in cell culture, ex-vivo tissues and in-vivo tissues using high frequency ultrasound imaging is provided. The method includes the steps of: 1) imaging a selected site of the cell culture or tissues using high frequency (above 20 MHz) ultrasound imaging (before image); 2) exposing the selected site to an apoptosis-inducing stress; 3) imaging the selected site or a portion thereof, using ultrasound imaging at subsequent timed intervals (after image(s)); 4) measuring the signal amplitude of a region of interest of the selected site in the before and after images; 5) comparing the signal amplitude measurements for the regions of interest in the before and after images and determining whether the after image regions exhibit an increase in amplitude as compared to the before image regions which is an indication that apoptosis has begun; and 6) measuring the change in the frequency spectrum of the radiofrequency ultrasound backscatter signal in the region of interest in the before and after images and confirming that apoptosis has begun when the slope of the frequency spectrum has increased.

Abstract translation: 提供了使用高频超声成像监测细胞培养，离体组织和体内组织凋亡的非侵入性方法。 该方法包括以下步骤：1）使用高频（高于20MHz）超声成像（图像之前）成像细胞培养物或组织的选定位点; 2）将选择的位点暴露于凋亡诱导应激; 3）在随后的定时间隔（图像之后）使用超声成像对所选择的位点或其部分进行成像; 4）测量前后图像中所选位置的感兴趣区域的信号幅度; 5）比较前后图像中感兴趣区域的信号幅度测量值，并确定后一图像区域是否与作为凋亡开始指示的先前图像区域之间的振幅增加; 以及6）测量前后图像中感兴趣区域中的射频超声后向散射信号的频谱变化，并确认当频谱的斜率增加时已经开始凋亡。