公开(公告)号：WO0053787A1

公开(公告)日：2000-09-14

申请号：PCT/NL0000152

申请日：2000-03-08

Applicant: STICHTING DIENST LANDBOUWKUNDI ,  MEULENBERG JANNEKE ,  NIEUWSTADT ANTONIE PAUL VAN ,  LANGEVELD JAN

Inventor： MEULENBERG JANNEKE ,  VAN NIEUWSTADT ANTONIE PAUL ,  LANGEVELD JAN

IPC: A61K39/00 ,  A61K39/12 ,  A61P31/12 ,  C07K14/08 ,  C12N7/01 ,  C12N7/04 ,  C12N15/40 ,  C12N15/86

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K2039/51 ,  A61K2039/5256 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/10043 ,  C12N2770/10061

Abstract: The invention relates to the field of PRRS viruses and infectious clones obtained from PRRS viruses. Furthermore, the invention relates to vaccines and diagnostic assays obtainable by using and modifying such infectious clones of PRRS viruses. The invention provides a porcine reproductive and respiratory syndrome virus (PRRSV) replicon having at least some of its original PRRSV nucleic acid deleted, said replicon capable of in vivo RNA replication, said replicon further having been deprived of at least some of its original PRRSV nucleic acid and/or having been supplemented with nucleic acid derived from a heterologous micro-organism.

Abstract translation: 本发明涉及从PRRS病毒获得的PRRS病毒和感染性克隆的领域。 此外，本发明涉及通过使用和修饰PRRS病毒感染性克隆而获得的疫苗和诊断测定法。 本发明提供了具有其原始PRRSV核酸的至少一些缺失的猪繁殖和呼吸综合征病毒（PRRSV）复制子，所述复制子能够进行体内RNA复制，所述复制子还被剥夺了其原始PRRSV核酸的至少一些 酸和/或已经补充有源自异源微生物的核酸。