公开(公告)号：WO2011018288A1

公开(公告)日：2011-02-17

申请号：PCT/EP2010/060086

申请日：2010-07-13

Applicant: BASF SE ,  STRAUSS, Volker ,  KAMP, Hennicke ,  FABIAN, Eric ,  COELHO PALERMO CUNHA, Georgia ,  MELLERT, Werner ,  VAN RAVENZWAAY, Bennard ,  WALK, Tilmann ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  WIEMER, Jan, C. ,  PROKOUDINE, Alexandre ,  LEIBOLD, Edgar

Inventor： STRAUSS, Volker ,  KAMP, Hennicke ,  FABIAN, Eric ,  COELHO PALERMO CUNHA, Georgia ,  MELLERT, Werner ,  VAN RAVENZWAAY, Bennard ,  WALK, Tilmann ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  WIEMER, Jan, C. ,  PROKOUDINE, Alexandre ,  LEIBOLD, Edgar

IPC: G01N33/50

CPC classification number: G01N33/6893 ,  G01N2800/046

Abstract: The present invention relates to a method for diagnosing thyroid disorders. It also relates to a method of determining whether a compound is capable of inducing a thyroid disorder in a subject and to a method of identifying a drug for treating a thyroid disorder. Furthermore, the present invention relates a device for diagnosing a thyroid disorder and diagnostic uses.

Abstract translation: 本发明涉及一种诊断甲状腺疾病的方法。 它还涉及确定化合物是否能够诱导受试者中的甲状腺疾病的方法以及鉴定用于治疗甲状腺疾病的药物的方法。 此外，本发明涉及用于诊断甲状腺疾病和诊断用途的装置。

公开(公告)号：WO2009153136A3

公开(公告)日：2010-03-18

申请号：PCT/EP2009056367

申请日：2009-05-26

Applicant: BASF SE ,  VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  COELHO PALERMO CUNHA GEORGIA ,  FABIAN ERIC ,  STRAUSS VOLKER ,  KAMP HENNICKE ,  WALK TILMANN B ,  LOOSER RALF ,  HEROLD MICHAEL MANFRED ,  WIEMER JAN C ,  PROKOUDINE ALEXANDRE ,  LEIBOLD EDGAR

Inventor： VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  COELHO PALERMO CUNHA GEORGIA ,  FABIAN ERIC ,  STRAUSS VOLKER ,  KAMP HENNICKE ,  WALK TILMANN B ,  LOOSER RALF ,  HEROLD MICHAEL MANFRED ,  WIEMER JAN C ,  PROKOUDINE ALEXANDRE ,  LEIBOLD EDGAR

IPC: G01N33/66 ,  G01N33/82 ,  G01N33/84 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N2500/00 ,  G01N2560/00 ,  G01N2800/085 ,  G01N2800/60 ,  Y02A90/26

Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention- pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol,myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (dl8:1, C24:1), Ceramide (dl8:2, C24:0), Sphingomyelin (dl8:1, C16:0), 1, 2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, CoenzymeQ9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides.

Abstract translation: 本发明涉及化学化合物危险分层的毒理学评估领域。 具体地说，涉及一种诊断肝毒性的方法。 它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。 此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝脏毒性的系统和装置。 最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。 对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。 肝毒性标志物主要选自游离脂肪酸，还包括各种磷脂酰胆碱，羟基苯基丙酮酸，α-生育酚，胆固醇，肌醇-2-单磷酸，4-羟基鞘氨醇，神经酰胺（dl8：1，C24：1） 神经酰胺（dl8：2，C24：0），鞘磷脂（dl8：1，C16：0），1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸，18:1溶血磷脂酰胆碱，辅酶Q9，葡萄糖， 甘油，磷酸甘油酯，磷酸酯，5-甲氧基肌氨酸，红细胞素，苏氨酸，二酰基甘油酯和三酰基甘油酯。

公开(公告)号：WO2007110357A3

公开(公告)日：2007-11-15

申请号：PCT/EP2007052691

申请日：2007-03-21

Applicant: METANOMICS GMBH ,  BETHAN BIANCA ,  BUSCH KRISTINA ,  WIEMER JAN ,  GIPMANS MARTIJN ,  LEIBOLD EDGAR ,  SPRANGER JOCHEN ,  BOBBERT THOMAS ,  PFEIFFER ANDREAS FRIEDRICH HER

Inventor： BETHAN BIANCA ,  BUSCH KRISTINA ,  WIEMER JAN ,  GIPMANS MARTIJN ,  LEIBOLD EDGAR ,  SPRANGER JOCHEN ,  BOBBERT THOMAS ,  PFEIFFER ANDREAS FRIEDRICH HER

IPC: G01N33/62 ,  G01N33/66 ,  G01N33/68 ,  G01N33/70 ,  G01N33/82 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N33/6848 ,  G01N33/6893 ,  G01N2800/042 ,  G01N2800/52 ,  Y10T436/144444 ,  Y10T436/24

Abstract: The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes. Finally, the present invention pertains to a method for identifying diabetes-related metabolites.

Abstract translation: 本发明涉及用于诊断糖尿病或其倾向性的方法，其包括测定怀疑患有糖尿病或具有倾向性的受试者的测试样品中的至少一种代谢物，并将所述至少一种代谢物与参照进行比较，由此 糖尿病或其易感性被诊断。 此外，本发明包括代谢物的集合，包含代谢物的特征值的数据集合和包含所述数据集合的存储介质。 此外，本发明还涉及一种系统，其包括用于比较可操作地连接到数据存储介质的样品的代谢物的特征值的装置。 本发明还包括包含至少一种代谢产物的诊断手段和所述至少一种代谢产物在制造用于诊断糖尿病的诊断手段中的用途。 最后，本发明涉及鉴定糖尿病相关代谢物的方法。

公开(公告)号：WO2011092285A3

公开(公告)日：2012-05-03

申请号：PCT/EP2011051208

申请日：2011-01-28

Applicant: METANOMICS GMBH ,  UNIV RUPRECHT KARLS HEIDELBERG ,  FUHRMANN JENS ,  RESZKA REGINA ,  KASTLER JUERGEN ,  BUSCH KRISTINA ,  LEIBOLD EDGAR ,  KATUS HUGO ,  FREY NORBERT ,  WOLF JOHANNA ,  WEIS TANJA

Inventor： FUHRMANN JENS ,  RESZKA REGINA ,  KASTLER JUERGEN ,  BUSCH KRISTINA ,  LEIBOLD EDGAR ,  KATUS HUGO ,  FREY NORBERT ,  WOLF JOHANNA ,  WEIS TANJA

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N33/64 ,  G01N33/6893 ,  G01N2570/00 ,  G01N2800/325 ,  G01N2800/52

Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

Abstract translation: 本发明涉及诊断方法领域。 具体地，本发明考虑了用于诊断受试者的心力衰竭的方法，用于识别受试者是否需要心力衰竭治疗的方法或用于确定心力衰竭疗法是否成功的方法。 本发明还涉及用于执行上述方法的工具，诸如诊断装置。

公开(公告)号：WO2010139711A1

公开(公告)日：2010-12-09

申请号：PCT/EP2010/057680

申请日：2010-06-02

Applicant: METANOMICS HEALTH GMBH ,  CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN ,  KAMLAGE, Beate ,  BETHAN, Bianca ,  RESZKA, Regina ,  LEIBOLD, Edgar ,  JUNG, Klaus ,  LEIN, Michael ,  KRISTIANSEN, Glen

Inventor： KAMLAGE, Beate ,  BETHAN, Bianca ,  RESZKA, Regina ,  LEIBOLD, Edgar ,  JUNG, Klaus ,  LEIN, Michael ,  KRISTIANSEN, Glen

IPC: G01N33/574

CPC classification number: G01N33/57484 ,  G01N33/57434

Abstract: The present invention relates to a method, preferably an ex vivo method, for diagnosing prostate carcinomas and/or predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from prostate carcinomas or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby prostate carcinomas or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metaboiite and the use of said at least one metabolite for the manufacture of diagnostic means for or for diagnosing prostate carcinomas. Finally, the present invention pertains to a method for identifying prostate carcinoma-related metabolites.

Abstract translation: 本发明涉及用于诊断前列腺癌和/或其倾向性的方法，优选离体方法，其包括测定怀疑患有前列腺癌的受试者的测试样品中的至少一种代谢物或具有易感性并比较 将至少一种代谢物称为参考，由此前列腺癌或其易感性被诊断。 此外，本发明包括代谢物的集合，包括代谢物的特征值的数据收集和包含所述数据收集的存储介质。 此外，本发明还涉及一种系统，其包括用于比较可操作地连接到数据存储介质的样品的代谢物的特征值的装置。 本发明进一步包括的是诊断方法，其包括至少一种生物元素和所述至少一种代谢产物用于制造用于诊断前列腺癌或用于诊断前列腺癌的诊断方法。 最后，本发明涉及鉴定前列腺癌相关代谢物的方法。

公开(公告)号：WO2009153139A2

公开(公告)日：2009-12-23

申请号：PCT/EP2009/056386

申请日：2009-05-26

Applicant: BASF SE ,  VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  WALK, Tilmann, B. ,  LOOSER, Ralf ,  LEIBOLD, Edgar ,  KAMP, Hennicke ,  COELHO PALERMO CUNHA, Georgia ,  HEROLD, Michael, Manfred ,  WIEMER, Jan, C. ,  PROKOUDINE, Alexandre

Inventor： VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  WALK, Tilmann, B. ,  LOOSER, Ralf ,  LEIBOLD, Edgar ,  KAMP, Hennicke ,  COELHO PALERMO CUNHA, Georgia ,  HEROLD, Michael, Manfred ,  WIEMER, Jan, C. ,  PROKOUDINE, Alexandre

IPC: G01N33/68 ,  G01N33/82 ,  G01N33/92 ,  G01N33/84

CPC classification number: G01N33/487 ,  G01N33/50 ,  G01N33/68 ,  G01N33/6812 ,  G01N33/82 ,  G01N33/92 ,  G01N2405/00 ,  G01N2500/00 ,  G01N2800/046 ,  G01N2800/10 ,  G01N2800/24 ,  G01N2800/60 ,  H01J49/0036 ,  Y10T436/200833 ,  Y10T436/24

Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.

Abstract translation: 本发明涉及化学化合物危险分层的毒理学评估领域。 具体而言，涉及诊断增加的过氧化物酶体增殖的方法。 它还涉及确定化合物是否能够诱导受试者中这种过氧化物酶体增殖的方法以及鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。 此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断增加的过氧化物酶体增殖的系统和装置。 最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中增加的过氧化物酶体增殖的诊断装置或组合物的用途。

公开(公告)号：WO9805607A3

公开(公告)日：1998-06-18

申请号：PCT/EP9704278

申请日：1997-08-06

Applicant: BARTH THOMAS ,  RIEBER NORBERT ,  GOLD RANDALL EVAN ,  DRESSEL JUERGEN ,  ERHARDT KLAUS ,  HORCHLER VON LOCQUENGH KLAUS ,  LEIBOLD EDGAR ,  RITTINGER STEFAN ,  BASF AG

Inventor： BARTH THOMAS ,  RIEBER NORBERT ,  GOLD RANDALL EVAN ,  DRESSEL JUERGEN ,  ERHARDT KLAUS ,  HORCHLER VON LOCQUENGH KLAUS ,  LEIBOLD EDGAR ,  RITTINGER STEFAN

IPC: C05F3/00 ,  C05G3/00 ,  C05G3/08 ,  C05G5/00 ,  C07D231/12 ,  C07D231/16 ,  C07D321/12 ,  C07D521/00

CPC classification number: C07D231/12 ,  C05F3/00 ,  C05G3/08 ,  C07D231/16 ,  C07D233/56 ,  C07D249/08 ,  Y02A40/205 ,  Y02P20/145 ,  Y02P60/218 ,  Y10S71/902

Abstract: The use of inorganic or organic poly acids is claimed for treating mineral fertilisers containing a nitrification inhibitor. The use of compounds of formula (I) is claimed as nitrification inhibitors. R1 = H, halo or 1-4C alkyl; R2 = 1-4C alkyl; R3 = H or CH2OH, and when R3 = H, the compound may be converted to a phosphoric acid salt. A mineral fertiliser containing a poly acid and optionally (I) is also claimed. 3,4-dimethylpyrazole (Ia), 4-chloro-3-methyl-pyrazole (Ib), N-hydroxymethyl-3,4-dimethylpyrazole (Ic), N-hydroxymethyl-4-chloro-3 -methylpyrazole (Id), acid addition salts of (Ic) and (Id), and mixtures of two or more of (Ia)-(d) are new. -

公开(公告)号：WO2007110357A2

公开(公告)日：2007-10-04

申请号：PCT/EP2007/052691

申请日：2007-03-21

Applicant: METANOMICS GmbH ,  BETHAN, Bianca ,  BUSCH, Kristina ,  WIEMER, Jan ,  GIPMANS, Martijn ,  LEIBOLD, Edgar ,  SPRANGER, Jochen ,  BOBBERT, Thomas ,  PFEIFFER, Andreas Friedrich Hermann

Inventor： BETHAN, Bianca ,  BUSCH, Kristina ,  WIEMER, Jan ,  GIPMANS, Martijn ,  LEIBOLD, Edgar ,  SPRANGER, Jochen ,  BOBBERT, Thomas ,  PFEIFFER, Andreas Friedrich Hermann

IPC: G01N33/62 ,  G01N33/66 ,  G01N33/68 ,  G01N33/70 ,  G01N33/92 ,  G01N33/82

CPC classification number: G01N33/92 ,  G01N33/6848 ,  G01N33/6893 ,  G01N2800/042 ,  G01N2800/52 ,  Y10T436/144444 ,  Y10T436/24

Abstract: The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes. Finally, the present invention pertains to a method for identifying diabetes-related metabolites.

Abstract translation: 本发明涉及一种用于诊断糖尿病或其易感性的方法，包括测定怀疑患有糖尿病的受试者的测试样品中的至少一种代谢物或具有易感性并将所述至少一种代谢物与参考对比，由此 要诊断糖尿病或其倾向。 此外，本发明包括代谢物的集合，包括代谢物的特征值的数据收集和包含所述数据收集的存储介质。 此外，本发明还涉及一种系统，其包括用于比较可操作地连接到数据存储介质的样品的代谢物的特征值的装置。 本发明进一步包括的是包含至少一种代谢物和所述至少一种代谢产物用于制造用于诊断糖尿病的诊断装置的诊断方法。 最后，本发明涉及鉴定糖尿病相关代谢物的方法。

公开(公告)号：WO2009153139A3

公开(公告)日：2010-02-18

申请号：PCT/EP2009056386

申请日：2009-05-26

Applicant: BASF SE ,  VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  FABIAN ERIC ,  STRAUSS VOLKER ,  WALK TILMANN B ,  LOOSER RALF ,  LEIBOLD EDGAR ,  KAMP HENNICKE ,  COELHO PALERMO CUNHA GEORGIA ,  HEROLD MICHAEL MANFRED ,  WIEMER JAN C ,  PROKOUDINE ALEXANDRE

Inventor： VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  FABIAN ERIC ,  STRAUSS VOLKER ,  WALK TILMANN B ,  LOOSER RALF ,  LEIBOLD EDGAR ,  KAMP HENNICKE ,  COELHO PALERMO CUNHA GEORGIA ,  HEROLD MICHAEL MANFRED ,  WIEMER JAN C ,  PROKOUDINE ALEXANDRE

IPC: G01N33/92 ,  G01N33/68 ,  G01N33/82 ,  G01N33/84

CPC classification number: G01N33/487 ,  G01N33/50 ,  G01N33/68 ,  G01N33/6812 ,  G01N33/82 ,  G01N33/92 ,  G01N2405/00 ,  G01N2500/00 ,  G01N2800/046 ,  G01N2800/10 ,  G01N2800/24 ,  G01N2800/60 ,  H01J49/0036 ,  Y10T436/200833 ,  Y10T436/24

Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18 :cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18 : cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidylcholine (C18 : 0/C22 : 6). Different multimarker sets are proposed for male and female subjects.

Abstract translation: 本发明涉及化学化合物危险分层的毒理学评估领域。 具体而言，涉及用于（i）诊断，（ii）确定化合物是否能够诱导，（iii）鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。 此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断的系统和装置。 最后，本发明涉及一组代谢物或装置用于制造诊断装置或组合物的用途。 代谢组胺的代谢物标记选自：辅酶Q10,16-甲基十七烷酸，17-甲基十八烷酸，二十碳三烯酸（C20：3），苏氨酸，脯氨酸，酪氨酸，反式-4-羟基丙酸，泛酸，辅酶Q9，甘油 ，棕榈酸（C16：0），Lmoleic acid（C18：顺式（9,12）2），14-甲基十六烷酸，γ-亚油酸（C18：顺式（6,9,12）3），苏氨酸， ，磷脂酰胆碱（C18：0 / C22：6）。 男性和女性受试者提出了不同的多标记组合。

公开(公告)号：WO2007110358A2

公开(公告)日：2007-10-04

申请号：PCT/EP2007/052692

申请日：2007-03-21

Applicant: METANOMICS GmbH ,  BETHAN, Bianca ,  BUSCH, Kristina ,  WIEMER, Jan ,  GIPMANS, Martijn ,  LEIBOLD, Edgar ,  SPRANGER, Jochen ,  BOBBERT, Thomas ,  PFEIFFER, Andreas Friedrich Hermann

Inventor： BETHAN, Bianca ,  BUSCH, Kristina ,  WIEMER, Jan ,  GIPMANS, Martijn ,  LEIBOLD, Edgar ,  SPRANGER, Jochen ,  BOBBERT, Thomas ,  PFEIFFER, Andreas Friedrich Hermann

IPC: G01N33/62 ,  G01N33/66 ,  G01N33/68 ,  G01N33/70 ,  G01N33/92 ,  G01N33/82

CPC classification number: G01N33/92 ,  G01N33/6848 ,  G01N33/6893 ,  G01N2800/042 ,  G01N2800/52 ,  Y10T436/144444 ,  Y10T436/24

Abstract: The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes. Finally, the present invention pertains to a method for identifying diabetes- related metabolites.

Abstract translation: 本发明涉及一种用于诊断糖尿病倾向的方法，其包括测定疑似患有糖尿病倾向的对象的测试样品中的至少一种代谢物，并将所述至少一种代谢物与参考对比，其中糖尿病的倾向是 被诊断。 此外，本发明包括代谢物的集合，包括代谢物的特征值的数据收集和包含所述数据收集的存储介质。 此外，本发明还涉及一种系统，其包括用于比较可操作地连接到数据存储介质的样品的代谢物的特征值的装置。 本发明进一步包括的是包含至少一种代谢物和所述至少一种代谢产物用于制备用于诊断糖尿病倾向的诊断装置的诊断方法。 最后，本发明涉及鉴定糖尿病相关代谢物的方法。