公开(公告)号：WO2004110983A8

公开(公告)日：2005-08-11

申请号：PCT/EP2004006330

申请日：2004-06-11

Applicant: S A L V A T LAB SA ,  FERNANDEZ SERRAT ANNA ,  SERRA COMAS CARME ,  BALSA LOPEZ DOLORS ,  LLEBARIA SOLDEVILA AMADEU ,  FARRERONS GALLEMI CARLES ,  MIQUEL BONO IGNACIO JOSE ,  CATENA RUIZ JUAN LORENZO ,  LAGUNAS ARNAL CARMEN ,  CORDOMI MONTOYA ARNAU ,  SALCEDO ROCA CAROLINA ,  TOLEDO MESA NATIVIDAD ,  MARRERO GONZALEZ PEDRO ,  HARO BAUTISTA DIEGO ,  FERNANDEZ GARCIA ANDRES

Inventor： FERNANDEZ SERRAT ANNA ,  SERRA COMAS CARME ,  BALSA LOPEZ DOLORS ,  LLEBARIA SOLDEVILA AMADEU ,  FARRERONS GALLEMI CARLES ,  MIQUEL BONO IGNACIO JOSE ,  CATENA RUIZ JUAN LORENZO ,  LAGUNAS ARNAL CARMEN ,  CORDOMI MONTOYA ARNAU ,  SALCEDO ROCA CAROLINA ,  TOLEDO MESA NATIVIDAD ,  MARRERO GONZALEZ PEDRO ,  HARO BAUTISTA DIEGO ,  FERNANDEZ GARCIA ANDRES

IPC: A61P5/00 ,  C07C235/52 ,  C07D209/18 ,  C07D213/30 ,  C07D215/20 ,  C07D215/22 ,  C07D215/227 ,  C07D215/26 ,  C07D223/16 ,  C07D233/54 ,  C07D241/44 ,  C07D277/64 ,  C07D333/16 ,  A61K31/166 ,  A61K31/381 ,  A61K31/404 ,  A61K31/435 ,  A61K31/498 ,  C07D209/04 ,  C07D213/02 ,  C07D241/40 ,  C07D333/08

CPC classification number: C07D213/30 ,  C07C235/52 ,  C07D209/18 ,  C07D215/20 ,  C07D215/227 ,  C07D215/26 ,  C07D223/16 ,  C07D233/54 ,  C07D241/44 ,  C07D277/64 ,  C07D333/16

Abstract: Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-­position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- ­and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPARϒ and PPARϒ/ PPARdelta modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.

Abstract translation: 一般结构（I）的化合物，其中中间苯环可以在间位或对位取代; -A是任选取代的羟基，烷氧基，羟胺，烷氧基胺或胺基; -W是从几种可能性中选择的N-和C-连接的双基; -Z是选自几种可能性的碳根。 这些化合物是PPARγ和PPARγ/PPARδ调节剂，因此可用于预防性和/或治疗性治疗由这些重症患者介导的病症或疾病。

公开(公告)号：WO2004110983A2

公开(公告)日：2004-12-23

申请号：PCT/EP2004006330

申请日：2004-06-11

Applicant: S A L V A T LAB SA ,  FERNANDEZ SERRAT ANNA ,  SERRA COMAS CARME ,  BALSA LOPEZ DOLORS ,  LLEBARIA SOLDEVILA AMADEU ,  FARRERONS GALLEMI CARLES ,  MIQUEL BONO IGNACIO JOSE ,  CATENA RUIZ JUAN LORENZO ,  LAGUNAS ARNAL CARMEN ,  CORDOMI MONTOYA ARNAU ,  SALCEDO ROCA CAROLINA ,  TOLEDO MESA NATIVIDAD ,  MARRERO GONZALEZ PEDRO ,  HARO BAUTISTA DIEGO ,  FERNANDEZ GARCIA ANDRES

Inventor： FERNANDEZ SERRAT ANNA ,  SERRA COMAS CARME ,  BALSA LOPEZ DOLORS ,  LLEBARIA SOLDEVILA AMADEU ,  FARRERONS GALLEMI CARLES ,  MIQUEL BONO IGNACIO JOSE ,  CATENA RUIZ JUAN LORENZO ,  LAGUNAS ARNAL CARMEN ,  CORDOMI MONTOYA ARNAU ,  SALCEDO ROCA CAROLINA ,  TOLEDO MESA NATIVIDAD ,  MARRERO GONZALEZ PEDRO ,  HARO BAUTISTA DIEGO ,  FERNANDEZ GARCIA ANDRES

IPC: A61P5/00 ,  C07C235/52 ,  C07D209/18 ,  C07D213/30 ,  C07D215/20 ,  C07D215/22 ,  C07D215/227 ,  C07D215/26 ,  C07D223/16 ,  C07D233/54 ,  C07D241/44 ,  C07D277/64 ,  C07D333/16 ,  C07C235/00

CPC classification number: C07D213/30 ,  C07C235/52 ,  C07D209/18 ,  C07D215/20 ,  C07D215/227 ,  C07D215/26 ,  C07D223/16 ,  C07D233/54 ,  C07D241/44 ,  C07D277/64 ,  C07D333/16

Abstract: Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-­position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- ­and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPARϒ and PPARϒ/ PPARdelta modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.

Abstract translation: 一般结构（I）的化合物，其中中间苯环可以在间位或对位取代; -A是任选取代的羟基，烷氧基，羟胺，烷氧基胺或胺基; -W是从几种可能性中选择的N-和C-连接的双基; -Z是选自几种可能性的碳根。 这些化合物是PPARγ和PPARγ/PPARδ调节剂，因此可用于预防性和/或治疗性治疗由这些重症患者介导的病症或疾病。

公开(公告)号：WO2012100835A1

公开(公告)日：2012-08-02

申请号：PCT/EP2011/051237

申请日：2011-01-28

Applicant: LABORATORIOS DEL DR. ESTEVE, S.A. ,  FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA ,  FABRIÀS DOMINGO, Gemma ,  GOÑI URCELAY, Félix ,  IZQUIERDO USEROS, Nuria ,  LLEBARIA SOLDEVILA, Amadeu ,  MAÑES BROTÓN, Santos ,  MARTÍNEZ PICADO, Javier

Inventor： FABRIÀS DOMINGO, Gemma ,  GOÑI URCELAY, Félix ,  IZQUIERDO USEROS, Nuria ,  LLEBARIA SOLDEVILA, Amadeu ,  MAÑES BROTÓN, Santos ,  MARTÍNEZ PICADO, Javier

IPC: A61K31/164 ,  A61P31/18

CPC classification number: A61K31/164 ,  A61K31/4425 ,  A61K2300/00

Abstract: The application relates to a method for the treatment of a disease caused by HIV infection by administering to a patient in need thereof of a specific inhibitor of the dehydroceramide desaturase. The invention relates as well to compositions comprising a Des-1inhibitor and one or more drugs suitable for the treatment of diseases caused by HIV infection as well as to methods for the identification of compounds suitable for the treatment of said diseases.

Abstract translation: 本申请涉及通过向有需要的患者施用脱氢神经酰胺去饱和酶的特异性抑制剂来治疗由HIV感染引起的疾病的方法。 本发明还涉及包含Des-1抑制剂和一种或多种适用于治疗由HIV感染引起的疾病的药物的组合物以及鉴定适用于治疗所述疾病的化合物的方法。

公开(公告)号：WO2004110983A3

公开(公告)日：2004-12-23

申请号：PCT/EP2004/006330

申请日：2004-06-11

Applicant: LABORATORIOS S.A.L.V.A.T., S.A. ,  FERNÁNDEZ SERRAT, Anna ,  SERRA COMAS, Carme ,  BALSA LÓPEZ, Dolors ,  LLEBARIA SOLDEVILA, Amadeu ,  FARRERONS GALLEMI, Carles ,  MIQUEL BONO, Ignacio José ,  CATENA RUIZ, Juan Lorenzo ,  LAGUNAS ARNAL, Carmen ,  CORDOMÍ MONTOYA, Arnau ,  SALCEDO ROCA, Carolina ,  TOLEDO MESA, Natividad ,  MARRERO GONZÁLEZ, Pedro ,  HARO BAUTISTA, Diego ,  FERNÁNDEZ GARCÍA, Andrés

Inventor： FERNÁNDEZ SERRAT, Anna ,  SERRA COMAS, Carme ,  BALSA LÓPEZ, Dolors ,  LLEBARIA SOLDEVILA, Amadeu ,  FARRERONS GALLEMI, Carles ,  MIQUEL BONO, Ignacio José ,  CATENA RUIZ, Juan Lorenzo ,  LAGUNAS ARNAL, Carmen ,  CORDOMÍ MONTOYA, Arnau ,  SALCEDO ROCA, Carolina ,  TOLEDO MESA, Natividad ,  MARRERO GONZÁLEZ, Pedro ,  HARO BAUTISTA, Diego ,  FERNÁNDEZ GARCÍA, Andrés

IPC: C07C235/52

Abstract: Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-­position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- ­and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPARϒ and PPARϒ/ PPARδ modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.

公开(公告)号：IL318651A

公开(公告)日：2025-03-01

申请号：IL31865125

申请日：2025-01-28

Applicant: SANIFIT THERAPEUTICS S A ,  SALCEDO ROCA CAROLINA ,  P?REZ FERRER MAR?A DEL MAR ,  FERRER REYN?S MIQUEL DAVID ,  SERRA COMAS CARME ,  CATENA RUIZ JUAN LORENZO ,  LLEBARIA SOLDEVILA AMADEU ,  PERELL? BESTARD JOAN ,  BASSISSI MOHAMAD FIRAS

Inventor： SALCEDO ROCA CAROLINA ,  P?REZ FERRER MAR?A DEL MAR ,  FERRER REYN?S MIQUEL DAVID ,  SERRA COMAS CARME ,  CATENA RUIZ JUAN LORENZO ,  LLEBARIA SOLDEVILA AMADEU ,  PERELL? BESTARD JOAN ,  BASSISSI MOHAMAD FIRAS

IPC: A61P19/00 ,  A61P43/00 ,  C07C35/16 ,  C07C43/188 ,  C07C43/196

Abstract: The present invention provides IP5 substituted compounds of general formula I, their methods of synthesis and their uses. The IP5 substituted compounds of the invention are characterized for having -O(alkyl)nX, and -O(alkyl)yCy(alkyl)y'-Z chains in positions R1, R2, R4, and R5. Also provided are methods, pharmaceutical compositions and formulations, methods of use, articles of manufacture, and kits for the treatment of diseases and conditions such as pathological crystallization-related diseases and conditions.