公开(公告)号：WO2019199667A3

公开(公告)日：2019-10-17

申请号：PCT/US2019/026313

申请日：2019-04-08

Applicant: KEANEY, Gregg F. ,  WANG, John ,  GERARD, Baudouin ,  ARAI, Kenzo ,  LIU, Xiang ,  ZHENG, Guo Zhu ,  KIRA, Kazunobu ,  MARCAURELLE, Lisa A. ,  NEVALAINEN, Marta ,  HAO, Ming-Hong ,  O'SHEA, Morgan Welzel ,  TIVITMAHAISOON, Parcharee ,  PRAJAPATI, Sudeep ,  LUO, Touping ,  GEARHART, Nicholas C. ,  LOWE, Jason T. ,  KOTAKE, Yoshihiko ,  NAGAO, Satoshi ,  KANADA SONOBE, Regina Mikie ,  MIYANO, Masayuki ,  MURAI, Norio ,  COOK, Andrew ,  ELLERY, Shelby ,  ENDO, Atsushi ,  PALACINO, James ,  REYNOLDS, Dominic

Inventor： KEANEY, Gregg F. ,  WANG, John ,  GERARD, Baudouin ,  ARAI, Kenzo ,  LIU, Xiang ,  ZHENG, Guo Zhu ,  KIRA, Kazunobu ,  MARCAURELLE, Lisa A. ,  NEVALAINEN, Marta ,  HAO, Ming-Hong ,  O'SHEA, Morgan Welzel ,  TIVITMAHAISOON, Parcharee ,  PRAJAPATI, Sudeep ,  LUO, Touping ,  GEARHART, Nicholas C. ,  LOWE, Jason T. ,  KOTAKE, Yoshihiko ,  NAGAO, Satoshi ,  KANADA SONOBE, Regina Mikie ,  MIYANO, Masayuki ,  MURAI, Norio ,  COOK, Andrew ,  ELLERY, Shelby ,  ENDO, Atsushi ,  PALACINO, James ,  REYNOLDS, Dominic

IPC: C07D313/00 ,  C07D407/12 ,  C07D407/14 ,  A61K31/497 ,  A61K31/4427 ,  A61K31/365 ,  A61P35/00

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

公开(公告)号：WO2019199667A2

公开(公告)日：2019-10-17

申请号：PCT/US2019/026313

申请日：2019-04-08

Applicant: KEANEY, Gregg F. ,  WANG, John ,  GERARD, Baudouin ,  ARAI, Kenzo ,  LIU, Xiang ,  ZHENG, Guo Zhu ,  KIRA, Kazunobu ,  MARCAURELLE, Lisa A. ,  NEVALAINEN, Marta ,  HAO, Ming-Hong ,  O'SHEA, Morgan Welzel ,  TIVITMAHAISOON, Parcharee ,  PRAJAPATI, Sudeep ,  LUO, Touping ,  GEARHART, Nicholas C. ,  LOWE, Jason T. ,  KOTAKE, Yoshihiko ,  NAGAO, Satoshi ,  KANADA SONOBE, Regina Mikie ,  MIYANO, Masayuki ,  MURAI, Norio ,  COOK, Andrew ,  ELLERY, Shelby ,  ENDO, Atsushi ,  PALACINO, James ,  REYNOLDS, Dominic

Inventor： KEANEY, Gregg F. ,  WANG, John ,  GERARD, Baudouin ,  ARAI, Kenzo ,  LIU, Xiang ,  ZHENG, Guo Zhu ,  KIRA, Kazunobu ,  MARCAURELLE, Lisa A. ,  NEVALAINEN, Marta ,  HAO, Ming-Hong ,  O'SHEA, Morgan Welzel ,  TIVITMAHAISOON, Parcharee ,  PRAJAPATI, Sudeep ,  LUO, Touping ,  GEARHART, Nicholas C. ,  LOWE, Jason T. ,  KOTAKE, Yoshihiko ,  NAGAO, Satoshi ,  KANADA SONOBE, Regina Mikie ,  MIYANO, Masayuki ,  MURAI, Norio ,  COOK, Andrew ,  ELLERY, Shelby ,  ENDO, Atsushi ,  PALACINO, James ,  REYNOLDS, Dominic

IPC: C07D313/00 ,  C07D407/12 ,  C07D407/14 ,  A61K31/497 ,  A61K31/4427 ,  A61K31/365 ,  A61P35/00

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

公开(公告)号：WO2019200100A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/026992

申请日：2019-04-11

Applicant: COOK, Andrew ,  REYNOLDS, Dominic ,  ZHONG, Cheng ,  BRAWN, Ryan ,  ELLERY, Shelby ,  SAMARAKOON, Thiwanka ,  LIU, Xiang ,  PRAJAPATI, Sudeep ,  SHEEHAN, Megan ,  LOWE, Jason T. ,  PALACINO, James

Inventor： COOK, Andrew ,  REYNOLDS, Dominic ,  ZHONG, Cheng ,  BRAWN, Ryan ,  ELLERY, Shelby ,  SAMARAKOON, Thiwanka ,  LIU, Xiang ,  PRAJAPATI, Sudeep ,  SHEEHAN, Megan ,  LOWE, Jason T. ,  PALACINO, James

IPC: C07D313/00 ,  C07D405/06 ,  C07D405/10 ,  C07D405/14 ,  C07D498/08 ,  C07D491/10 ,  A61K31/365 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/416 ,  A61K31/4025 ,  A61K31/4545 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04

Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy.