公开(公告)号：WO2010096662A1

公开(公告)日：2010-08-26

申请号：PCT/US2010/024750

申请日：2010-02-19

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  LO, Ying-Cheng ,  AKONUR, Alp ,  MARTIS, Isaac ,  HAYES, Andrew

Inventor： LO, Ying-Cheng ,  AKONUR, Alp ,  MARTIS, Isaac ,  HAYES, Andrew

IPC: A61M1/28 ,  G06F19/00

CPC classification number: A61M1/28 ,  A61M1/1613 ,  A61M1/287 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/50

Abstract: A method for peritoneal dialysis treatment includes (i) predicting results of a plurality of patient therapy outcomes for a plurality of different mixed dextrose level dialysis solutions; (ii) selecting one of the mixed dextrose level solutions for a patient based on the results; and (iii) performing at least one therapy using different unmixed dextrose level solutions that combine to simulate a like cumulative concentration that would be achieved using the selected mixed dextrose level solution.

Abstract translation: 腹膜透析治疗的方法包括（i）预测多种不同混合葡萄糖水平透析溶液的多种患者治疗结果的结果; （ii）基于结果选择患者的混合葡萄糖水平溶液之一; 和（iii）使用不同的未混合的葡萄糖水平溶液进行至少一种治疗，其组合以模拟使用所选择的混合葡萄糖水平溶液实现的相似的累积浓度。

公开(公告)号：WO2009134881A4

公开(公告)日：2009-12-10

申请号：PCT/US2009042106

申请日：2009-04-29

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  LO YING-CHENG ,  AKONUR ALP ,  MARTIS ISAAC

Inventor： LO YING-CHENG ,  AKONUR ALP ,  MARTIS ISAAC

IPC: A61M1/28 ,  G06F19/00

CPC classification number: G06F19/3481 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M2205/3569 ,  A61M2205/52 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072

Abstract: Peritoneal dialysis therapy outcomes have been calculated for a variety of dwell times of peritoneal dialysis fluids in the peritoneal cavities of dialysis patients using kinetic modeling. The length of dwell time should not be the same for every patient, but should vary according to the patient condition and needs. Some patients have a potential for expressing greater ultrafiltrate into the dialysis fluid, and these patients can benefit from a longer dwell time, whereas other patients with less potential will not benefit from a longer dwell time. An optimal or peak time is observed for each peritoneal dialysis therapy outcome, such as ultrafiltrate volume rate, urea clearance (Kt/V), and creatinine clearance, while minimizing hydrocarbon absorption. These values and input parameters can be used to tailor the peritoneal dialysis dwell time for each patient, estimating the peak dwell time that will yield the best therapy outcome for each patient.

Abstract translation: 已经使用动力学模型计算了透析患者腹膜腔腹膜透析液的各种停留时间的腹膜透析治疗结果。 每个患者的停留时间长度不应相同，但应根据患者情况和需要而变化。 一些患者有可能在透析液中表达更多的超滤液，这些患者可以从更长的停留时间中受益，而潜在的潜力较小的患者不会受益于更长的停留时间。 对于每个腹膜透析治疗结果，观察到最佳或高峰时间，例如超滤液体积率，尿素清除率（Kt / V）和肌酐清除率，同时使烃吸收最小化。 这些值和输入参数可用于定制每个患者的腹膜透析停留时间，估计将为每位患者产生最佳治疗结果的峰停留时间。

公开(公告)号：WO2009134881A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/042106

申请日：2009-04-29

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  LO, Ying-cheng ,  AKONUR, Alp ,  MARTIS, Isaac

Inventor： LO, Ying-cheng ,  AKONUR, Alp ,  MARTIS, Isaac

IPC: A61M1/28 ,  G06F19/00

CPC classification number: G06F19/3481 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M2205/3569 ,  A61M2205/52 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072 ,  G06F19/00

Abstract: Peritoneal dialysis therapy outcomes have been calculated for a variety of dwell times of peritoneal dialysis fluids in the peritoneal cavities of dialysis patients using kinetic modeling. The length of dwell time should not be the same for every patient, but should vary according to the patient condition and needs. Some patients have a potential for expressing greater ultrafiltrate into the dialysis fluid, and these patients can benefit from a longer dwell time, whereas other patients with less potential will not benefit from a longer dwell time. An optimal or peak time is observed for each peritoneal dialysis therapy outcome, such as ultrafiltrate volume rate, urea clearance (Kt/V), and creatinine clearance, while minimizing hydrocarbon absorption. These values and input parameters can be used to tailor the peritoneal dialysis dwell time for each patient, estimating the peak dwell time that will yield the best therapy outcome for each patient.

Abstract translation: 已使用动力学建模计算透析患者腹膜腔中腹膜透析液的各种停留时间的腹膜透析治疗结果。 每个患者的停留时间不应该相同，但应根据患者的状况和需要而有所不同。 一些患者有可能在透析液中表达更大的超滤液，并且这些患者可以从更长的停留时间获益，而其他潜力较低的患者不会从更长的停留时间获益。 观察每个腹膜透析治疗结果的最佳时间或高峰时间，例如超滤液体积速率，尿素清除率（Kt / V）和肌酸酐清除率，同时使碳氢化合物吸收最小化。 这些数值和输入参数可用于为每位患者量身定制腹膜透析停留时间，估计峰值停留时间，从而为每位患者产生最佳治疗结果。