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    Targeting of nucleic acid to liver
    2.
    发明专利
    Targeting of nucleic acid to liver 审中-公开
    对核酸的定位

    公开(公告)号：JP2005170877A

    公开(公告)日：2005-06-30

    申请号：JP2003414504

    申请日：2003-12-12

    Applicant: Japan Science & Technology Agency ,  Yasuhiko Tabata ,  Masaya Yamamoto ,  雅哉 山本 ,  独立行政法人科学技術振興機構 ,  泰彦 田畑

    Inventor： YAMAMOTO MASAYA ,  TABATA YASUHIKO

    IPC: C12N15/09 ,  A61K31/7052 ,  A61K47/36 ,  A61K48/00 ,  A61P1/16

    Abstract: PROBLEM TO BE SOLVED: To provide a preparation for enhancing efficiency of targeting of a nucleic acid to a liver cell and efficiency of intracellular uptake.
    SOLUTION: The preparation for liver delivery comprises a polyion complex formed from a nucleic acid and a cationized pullulan derivative. In the preparation, the molecular weight used is preferably 30,000-60,000 and a ratio of number of moles of an amino group in the catioized pullulan derivative to number of moles of a phosphoric acid group in the nucleic acid is preferably 3-7.
    COPYRIGHT: (C)2005,JPO&NCIPI

    Abstract translation: 待解决的问题：提供用于提高核酸靶向肝细胞的效率的制备和细胞内摄取的效率。 解决方案：用于肝递送的制剂包含由核酸和阳离子化支链淀粉衍生物形成的聚离子络合物。 在制备中，所用的分子量优选为30,000-60,000，并且所述上链状支链淀粉衍生物中的氨基的摩尔数与核酸中磷酸基的摩尔数之比优选为3-7。 版权所有（C）2005，JPO＆NCIPI

    Hybrid vehicle and parameter display method for hybrid vehicle
    7.
    发明授权
    Hybrid vehicle and parameter display method for hybrid vehicle 有权
    混合动力汽车的混合动力车辆和参数显示方法

    公开(公告)号：US09254757B2

    公开(公告)日：2016-02-09

    申请号：US13147149

    申请日：2009-09-11

    Applicant: Masaya Yamamoto ,  Yujin Gotoda ,  Koji Nomura ,  Takeshi Torii

    Inventor： Masaya Yamamoto ,  Yujin Gotoda ,  Koji Nomura ,  Takeshi Torii

    IPC: B60W20/00 ,  B60L11/18 ,  B60K6/445 ,  B60L11/12 ,  B60L11/14 ,  B60W50/14

    CPC classification number: B60W20/10 ,  B60K6/445 ,  B60K2350/1092 ,  B60L11/123 ,  B60L11/14 ,  B60L11/1864 ,  B60L2210/40 ,  B60L2250/16 ,  B60W20/00 ,  B60W50/14 ,  B60W2050/146 ,  B60W2710/0677 ,  Y02T10/6217 ,  Y02T10/6239 ,  Y02T10/7005 ,  Y02T10/7061 ,  Y02T10/7077 ,  Y02T10/7241 ,  Y02T10/84

    Abstract: On a display, a running power determined in accordance with an accelerator position or the like is displayed. When the hybrid vehicle is controlled in a CS mode, the running power is displayed together with eco-acceleration power greater than a first engine starting power. When the hybrid vehicle is controlled in a CD mode, the running power is displayed together with a second engine starting power in place of the eco-acceleration power. The engine is stopped when the running power is smaller than the first engine starting threshold value in the CS mode. The engine is driven when the running power is equal to or greater than the first engine starting threshold value in the CS mode. The engine is stopped when the running power is smaller than a second engine starting threshold value in the CD mode. The engine is driven when the running power is equal to or greater than the second engine starting threshold value in the CD mode. The second engine starting threshold value is greater than the first engine starting threshold value.

    Abstract translation: 在显示器上显示根据加速器位置等确定的行驶功率。 当混合动力车辆被控制在CS模式时，运行功率与大于第一发动机起动功率的生态加速功率一起显示。 当混合动力车辆被控制在CD模式时，运行功率与第二发动机起动功率一起显示，代替生态加速功率。 当运行功率小于CS模式下的第一发动机起动阈值时，发动机停止。 当运行功率等于或大于CS模式中的第一发动机起动阈值时，发动机被驱动。 当运行功率小于CD模式中的第二发动机起动阈值时，发动机停止。 当运行功率等于或大于CD模式中的第二发动机起动阈值时，发动机被驱动。 第二发动机起动阈值大于第一发动机起动阈值。

    Hybrid vehicle and control method of hybrid vehicle
    8.
    发明授权
    Hybrid vehicle and control method of hybrid vehicle 有权
    混合动力汽车的混合动力车辆和控制方法

    公开(公告)号：US09233682B2

    公开(公告)日：2016-01-12

    申请号：US13984658

    申请日：2011-02-10

    Applicant: Hiroki Endo ,  Masaya Yamamoto

    Inventor： Hiroki Endo ,  Masaya Yamamoto

    IPC: B60W20/00 ,  B60K6/445 ,  B60W10/06 ,  B60W10/08

    CPC classification number: B60W20/13 ,  B60K6/445 ,  B60W10/06 ,  B60W10/08 ,  B60W20/00 ,  B60W2510/085 ,  B60W2540/10 ,  B60W2540/12 ,  B60W2710/0644 ,  B60W2710/083 ,  Y02T10/6239 ,  Y02T10/6286 ,  Y10S903/903

    Abstract: Vehicle includes an engine, a first rotating electric machine and a control device controlling the rotational speed of the first rotating electric machine such that the rotational speed of the engine matches a target rotational speed. The control device calculates a torque command value of the first rotating electric machine based on an upper limit value of electric power discharged from a power storage device supplying electric power to the first rotating electric machine. The control device calculates the torque command of the first rotating electric machine based on a further restricted value of the upper limit value when a torque restricting condition including simultaneous operation of an accelerator pedal and brake pedal is met.

    Abstract translation: 车辆包括发动机，第一旋转电机和控制第一旋转电机的转速使得发动机的转速与目标转速匹配的控制装置。 控制装置基于从向第一旋转电机供给电力的蓄电装置排出的电力的上限值，计算第一旋转电机的转矩指令值。 当满足包括加速器踏板和制动踏板的同时操作的转矩限制条件时，控制装置基于上限值的另一限制值来计算第一旋转电机的转矩指令。

    Control device of hybrid system
    9.
    发明授权
    Control device of hybrid system 有权
    混合系统的控制装置

    公开(公告)号：US09162675B2

    公开(公告)日：2015-10-20

    申请号：US14343972

    申请日：2011-12-13

    Applicant: Masaya Yamamoto

    Inventor： Masaya Yamamoto

    IPC: B60L11/00 ,  B60W20/00 ,  B60W10/06 ,  B60W10/08 ,  B60K6/48 ,  B60K26/04

    CPC classification number: B60W20/40 ,  B60K6/48 ,  B60K2026/046 ,  B60W10/06 ,  B60W10/08 ,  B60W20/10 ,  B60W2540/10 ,  Y02T10/6221 ,  Y02T10/6286 ,  Y10S903/93

    Abstract: The invention relates to a control device of a hybrid system. The control device selectively performs first and second modes for concomitantly using an EV mode for operating the electric motor (12) with the engine operation being stopped and an HV mode for selectively operating the engine and stopping the engine operation with the electric motor being operated by switching the EV and HV modes according to a predetermined switching condition set such that a proportion of an engine operation time in the first mode is smaller than that in the second mode. When an actual acceleration pedal manipulation amount is smaller than a first manipulation amount, an amount of the hybrid system power increased according to the increasing of the actual acceleration pedal manipulation amount in the first mode is made larger than that in the second mode.

    Abstract translation: 本发明涉及一种混合系统的控制装置。 控制装置选择性地执行第一和第二模式，以随机地使用EV模式来操作发动机操作停止的电动机（12），以及HV模式，用于选择性地操作发动机并且停止发动机操作，电动机由 根据设定的预定切换条件切换EV和HV模式，使得第一模式中的发动机运转时间的比例小于第二模式中的发动机运转时间的比例。 当实际的加速踏板操作量小于第一操作量时，根据第一模式中的实际加速踏板操作量的增加，混合动力系统功率的增加量大于第二模式。

    Hybrid vehicle
    10.
    发明授权
    Hybrid vehicle 有权
    混合动力汽车

    公开(公告)号：US09073536B2

    公开(公告)日：2015-07-07

    申请号：US14365719

    申请日：2011-12-15

    Applicant: Hiroki Endo ,  Masaya Yamamoto ,  Kensuke Kamichi ,  Yusuke Yamanaka

    Inventor： Hiroki Endo ,  Masaya Yamamoto ,  Kensuke Kamichi ,  Yusuke Yamanaka

    IPC: B60W10/08 ,  B60K6/445 ,  B60W10/06 ,  B60W20/00

    CPC classification number: B60W10/08 ,  B60K6/445 ,  B60W10/06 ,  B60W20/00 ,  B60W20/40 ,  B60W2540/103 ,  Y02T10/6239 ,  Y02T10/6286 ,  Y10S903/93

    Abstract: A hybrid vehicle for reducing a variation in accelerator position when an EV mode is switched to a HV mode is provided. A controller executes the following process during running in the EV mode. The controller sets an increase of the accelerator position from a first accelerator position to a switching accelerator position at which a switch to the HV mode is to be made as a first increase when an output of a motor has reached an output upper limit at the first accelerator position. The controller sets an increase of the accelerator position from a second accelerator position to the switching accelerator position as a second increase which is smaller than the first increase when the output of the motor has reached the output upper limit at the second accelerator position which is larger than the first accelerator position.

    Abstract translation: 提供了一种用于在EV模式切换到HV模式时减少加速器位置的变化的混合动力车辆。 控制器在EV模式下运行时执行以下处理。 控制器将加速器位置从第一加速器位置增加到切换加速器位置，在马达的输出达到第一加速器的输出上限时，要切换到HV模式的开关加速器位置作为第一增加 加速器位置。 控制器将加速器位置从第二加速器位置增加到切换加速器位置，作为比第一增加小的第二增加，当马达的输出达到第二加速器位置的输出上限时较大 比第一个加速器的位置。

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