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公开(公告)号:WO2007113566A3
公开(公告)日:2007-11-29
申请号:PCT/GB2007001249
申请日:2007-04-05
Applicant: STFC SCIENCE & TECHNOLOGY , MATOUSEK PAVEL , PARKER ANTHONY WILLIAM
Inventor: MATOUSEK PAVEL , PARKER ANTHONY WILLIAM
IPC: G01N21/65
CPC classification number: G01N21/65 , A61B5/417 , G01N2021/656 , G07D7/1205
Abstract: Properties of turbid or scattering samples are determined using Raman spectroscopy with probe light delivered to and subsequently collected from the sample using a transmission geometry. The technique may be applied to pharmaceutical products such as tablets, diagnostic tests such as lateral flow diagnostic strips, and elsewhere.
Abstract translation: 使用拉曼光谱法测定混浊或散射样品的性质,其中使用传输几何形式将样品中的探针光输送至随后的样品。 该技术可以应用于药物制品如片剂,诊断试验如侧流诊断条和其他地方。
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公开(公告)号:WO2007113581A1
公开(公告)日:2007-10-11
申请号:PCT/GB2007/001289
申请日:2007-04-05
Inventor: ANDREWS, Darren , MATOUSEK, Pavel
CPC classification number: G01N21/65 , A61B5/417 , G01N2021/656 , G07D7/1205
Abstract: Data is embedded within a carrier medium using one or more tag regions, each tag region comprising a Raman tag species selected from a plurality of tag species having distinct Raman spectral signatures. The tag regions may be read by detecting Raman spectral features in light scattered through the medium in a transmission geometry.
Abstract translation: 使用一个或多个标签区将数据嵌入载体介质中,每个标签区域包括选自具有不同拉曼光谱特征的多个标签物种的拉曼标签物种。 可以通过在透射几何形状中通过介质散射的光检测拉曼光谱特征来读取标签区域。
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公开(公告)号:WO2006061566A1
公开(公告)日:2006-06-15
申请号:PCT/GB2005/004535
申请日:2005-11-25
Applicant: COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS , MATOUSEK, Pavel , PARKER, Anthony, William
Inventor: MATOUSEK, Pavel , PARKER, Anthony, William
CPC classification number: A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/441 , A61B5/4504 , G01N21/65 , G01N2021/656
Abstract: Apparatus and methods for detecting Raman spectral features non destructively from sub-surface regions of a diffusely scattering sample are disclosed. Incident radiation is supplied at one or more sample surface entry regions, and light is collected from one or more collection regions spaced from the entry regions. Raman features are detected in the collected light, and depth information is derived according to the entry-collection spacings.
Abstract translation: 公开了从漫散射样品的子表面区域非破坏性地检测拉曼光谱特征的装置和方法。 在一个或多个样品表面进入区域处提供入射辐射,并且从与入口区域间隔开的一个或多个收集区域收集光。 在收集的光中检测到拉曼特征,并根据入场收集间隔导出深度信息。
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公开(公告)号:WO2005119728A3
公开(公告)日:2005-12-15
申请号:PCT/GB2005/002240
申请日:2005-06-06
Applicant: COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS , MATOUSEK, Pavel , PARKER, Anthony, William
Inventor: MATOUSEK, Pavel , PARKER, Anthony, William
Abstract: A scanning tunneling microscope tip (15) is used to direct a rapidly switched stream of electrons at a target surface (12) by applying an electrical bias which brings the tip (16) close to the auto-emission threshold, and then using a pulsed laser (18) source directed at the tip (16) to trigger emission. Applications include high time and space resolution spectroscopy, and data recording apparatus.
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公开(公告)号:WO2005119728A2
公开(公告)日:2005-12-15
申请号:PCT/GB2005002240
申请日:2005-06-06
Applicant: COUNCIL CENT LAB RES COUNCILS , MATOUSEK PAVEL , PARKER ANTHONY WILLIAM
Inventor: MATOUSEK PAVEL , PARKER ANTHONY WILLIAM
IPC: G01Q10/00 , G01Q30/02 , G01Q60/10 , G01Q60/12 , G01Q60/16 , G01Q70/12 , G01Q80/00 , G11B9/00 , G11B9/10 , H01J3/02 , H01J31/00 , H01J37/073
CPC classification number: G01Q30/02 , G01Q60/16 , G01Q70/12 , G01Q80/00 , G11B9/10 , G11B9/14 , H01J37/073 , H01J2237/06333
Abstract: A scanning tunneling microscope tip is used to direct a rapidly switched stream of electrons at a target surface by applying an electrical bias which brings the tip close to the auto-emission threshold, and then using a pulsed laser source directed at the tip to trigger emission. Applications include high time and space resolution spectroscopy, and data recording apparatus.
Abstract translation: 扫描隧道显微镜尖端用于通过施加使尖端接近自发射阈值的电偏压来引导目标表面处的快速切换的电子流,然后使用指向尖端的脉冲激光源来触发发射 。 应用包括高分辨率时空分辨率和数据记录装置。
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公开(公告)号:WO2007113566A2
公开(公告)日:2007-10-11
申请号:PCT/GB2007/001249
申请日:2007-04-05
Applicant: THE SCIENCE AND TECHNOLOGY FACILITIES COUNCIL , MATOUSEK, Pavel , PARKER, Anthony, William
Inventor: MATOUSEK, Pavel , PARKER, Anthony, William
IPC: G01N21/65
CPC classification number: G01N21/65 , A61B5/417 , G01N2021/656 , G07D7/1205
Abstract: Properties of turbid or scattering samples are determined using Raman spectroscopy with probe light delivered to and subsequently collected from the sample using a transmission geometry. The technique may be applied to pharmaceutical products such as tablets, diagnostic tests such as lateral flow diagnostic strips, and elsewhere.
Abstract translation: 浑浊或散射样品的性质使用拉曼光谱测定,其中使用透射几何结构将探测光输送至样品并随后从样品收集。 该技术可应用于药物产品,如片剂,诊断检测如横向流动诊断带等。 p>
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公开(公告)号:WO2007060467A1
公开(公告)日:2007-05-31
申请号:PCT/GB2006/004428
申请日:2006-11-27
Applicant: THE COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS , MATOUSEK, Pavel , PARKER, Anthony, William
Inventor: MATOUSEK, Pavel , PARKER, Anthony, William
IPC: G01N21/65
CPC classification number: G01N21/65
Abstract: Method and apparatus for screening objects using Raman scattering methods to detect the presence of predefined substances or classes of substances. The predefined substances may be hazardous, toxic, or explosive. Radiation is supplied to an incident region of an object. Scattered light is collected from a collection region on the surface of the object spaced from the incident region. The characteristics of the scattered light include Raman features related to the predefined substances. The Raman features allow the presence, or not, of the predefined substances to be determined.
Abstract translation: 使用拉曼散射法检测物体的方法和装置,以检测预定物质或物质类别的存在。 预定义的物质可能是危险的,有毒的或有爆炸性的。 辐射被提供给物体的入射区域。 从与入射区域间隔开的物体表面上的收集区域收集散射光。 散射光的特征包括与预定义物质相关的拉曼特征。 拉曼特征允许确定预定义物质的存在或不存在。
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公开(公告)号:WO2006061565A1
公开(公告)日:2006-06-15
申请号:PCT/GB2005/004529
申请日:2005-11-25
Applicant: COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS , MATOUSEK, Pavel , PARKER, Anthony, William
Inventor: MATOUSEK, Pavel , PARKER, Anthony, William
CPC classification number: A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/441 , A61B5/4504 , G01N21/65 , G01N2021/656
Abstract: Apparatus and methods for determining, in-vivo, characteristics of sub-surface tissues or fluids in the human or animal body are disclosed. Incident radiation is supplied at one or more entry regions on a surface, and light is collected from one or more collection regions spaced from the entry regions. Raman features are detected in the collected light and depth related information derived therefrom.
Abstract translation: 公开了用于确定人体或动物体内的亚表面组织或流体的体内特征的装置和方法。 入射辐射在表面上的一个或多个进入区域处供应,并且从与入口区域间隔开的一个或多个收集区域收集光。 在从其中得到的收集的光和深度相关信息中检测到拉曼特征。
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公开(公告)号:WO2008110825A1
公开(公告)日:2008-09-18
申请号:PCT/GB2008/000919
申请日:2008-03-14
Inventor: MATOUSEK, Pavel
CPC classification number: G01N21/47 , G01J3/10 , G01J3/44 , G01N21/49 , G01N21/65 , G01N21/658 , G01N2021/4735
Abstract: The invention provides a technique for increasing the illumination intensity of probe light in a diffusely scattering sample without increasing the power of the probe beam. Generally, an optical filter is used which permits a collimated probe beam of light to pass through to the sample, but which reflects back towards the sample much of the backscattered scattered probe light emerging at a wider range of angles. In particular embodiments a collimated laser beam is delivered to the sample through a multilayer dielectric filter covering a portion of the sample. The filter is transmissive to the laser light at normal incidence, but reflective at shallower angles of incidence characteristic of the backscattered light.
Abstract translation: 本发明提供了一种用于在不增加探测光束的功率的情况下增加漫散射样品中的探测光的照明强度的技术。 通常,使用光学滤光器,其允许准直的探测光束通过样品,但是反射回样品大部分在更宽范围的角度上出现的背散射的散射探测光。 在特定实施例中,准直激光束通过覆盖样品的一部分的多层介质滤波器传送到样品。 滤光器在正常入射时对激光透射,但反射在较浅的背散射光入射角。
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公开(公告)号:WO2008062185A1
公开(公告)日:2008-05-29
申请号:PCT/GB2007/004452
申请日:2007-11-21
Applicant: THE SCIENCE AND TECHNOLOGY FACILITIES COUNCIL , MATOUSEK, Pavel , ELIASSON, Eva, Charlotte
Inventor: MATOUSEK, Pavel , ELIASSON, Eva, Charlotte
Abstract: Methods and apparatus for screening the unknown contents of containers using Raman spectroscopy are disclosed, especially for security screening applications such as in airports. A probe light beam is directed through the wall of a container to a sample region within the container contents. Light scattered out of the beam within the sample region is collected along a path which passes through a separate part of the container wall, for Raman spectral analysis.
Abstract translation: 使用拉曼光谱法筛选容器未知含量的方法和装置
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