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    Method for imaging on thin solid-state interface between two fluids
    5.
    发明专利
    Method for imaging on thin solid-state interface between two fluids 未知

    公开(公告)号：IL215351A

    公开(公告)日：2016-04-21

    申请号：IL21535111

    申请日：2011-09-25

    Applicant: UNIV BOSTON ,  SONI GAUTAM VIVEK ,  MELLER AMIT

    Inventor： SONI GAUTAM VIVEK ,  MELLER AMIT

    IPC: G01N20060101

    Abstract: Described herein is a fluid cell for an optical microscopy tool having a solid state membrane having a first side and a second, opposing side; a first fluid chamber comprising a first fluid having a first refractive index located on the first side of the membrane; and, a second fluid chamber comprising a second fluid having a second refractive index located on the second side of the membrane, the second refractive index being different than the first refractive index. Also described herein is a method for imaging a single biomolecule, the method including generating a field of evanescent illumination at a solid state membrane between a first fluid and a second fluid having different refractive indexes; and detecting light emitted by optical detectors linked to the single biomolecules at the solid state membrane.

    AN ULTRA HIGH-THROUGHPUT OPTI-NANOPORE DNA READOUT PLATFORM
    7.
    发明专利
    AN ULTRA HIGH-THROUGHPUT OPTI-NANOPORE DNA READOUT PLATFORM 未知

    公开(公告)号：IL181262D0

    公开(公告)日：2008-03-20

    申请号：IL18126207

    申请日：2007-02-11

    Applicant: UNIV HARVARD ,  MELLER AMIT ,  MATHE JEROME ,  EID JOHN S

    IPC: B82B20100101

    Abstract: Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzipping of DNA (or RNA) double strands, and (2) the readout of the molecule's identity (or code) using one or more molecule signal detection.

    LABEL-FREE SENSING OF PNA-DNA COMPLEXES USING NANOPORES
    9.
    发明申请
    LABEL-FREE SENSING OF PNA-DNA COMPLEXES USING NANOPORES 审中-公开
    使用NANOPORES的PNA-DNA复合物的无标签感测

    公开(公告)号：WO2011028494A3

    公开(公告)日：2011-06-16

    申请号：PCT/US2010046403

    申请日：2010-08-24

    Applicant: UNIV BOSTON ,  MELLER AMIT ,  FRANK-KAMENETSKII MAXIM ,  WANUNU MENI ,  KUHN HEIKO ,  SINGER ALON ,  MORRISON WILL

    Inventor： MELLER AMIT ,  FRANK-KAMENETSKII MAXIM ,  WANUNU MENI ,  KUHN HEIKO ,  SINGER ALON ,  MORRISON WILL

    IPC: C12Q1/68 ,  C12N15/11 ,  C12R1/145 ,  C12R1/35 ,  C12R1/44

    CPC classification number: C12Q1/6839 ,  C12Q1/689 ,  G01N33/48721 ,  C12Q2525/107

    Abstract: Embodiments disclosed herein relate to a method of detecting specific DNA sequences and the application of this method in the detection of pathogens, viruses, drug-resistant pathogens, genomic variations associated with disease/disorder susceptibility etc. based on specific signature sequences unique to the pathogens, viruses, drug-resistant pathogens or genomic variations. The method can also be used to distinguish a pool of same-sized dsDNA on the basis of sequence differences. The method uses non-optically labeled bis-PNA and/or gamma-PNA probes to tag specific target sequences for identification by solid-state nanopores.

    Abstract translation: 本文公开的实施方案涉及检测特定DNA序列的方法以及该方法在检测病原体，病毒，耐药性病原体，与疾病/病症易感性等相关的基因组变异的基础上的应用，其基于病原体特有的特异性特征序列 ，病毒，耐药病原体或基因组变体。 该方法也可用于根据序列差异区分相同大小的dsDNA库。 该方法使用非光学标记的双-PNA和/或γ-PNA探针来标记特异性靶序列以便通过固态纳米孔鉴定。

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