公开(公告)号：WO2008085938A3

公开(公告)日：2009-01-29

申请号：PCT/US2008000190

申请日：2008-01-07

Applicant: ROSALIND FRANKLIN UNIVERSITY O ,  MENESES PATRICIO I ,  ROBERTSON ERLE S ,  NGUYEN KHA ,  LANIOSZ VALERIE

Inventor： MENESES PATRICIO I ,  ROBERTSON ERLE S ,  NGUYEN KHA ,  LANIOSZ VALERIE

IPC: C07K16/00 ,  A61K39/395

CPC classification number: C07K16/084 ,  A61K39/00 ,  A61K39/12 ,  C07K14/005 ,  C07K2317/76 ,  C07K2317/77 ,  C12N2710/20022 ,  C12N2710/20034

Abstract: The present invention relates generally to an antibody that binds specifically to a neutralization epitope at the surface of papillomavirus (residues 36-49 of the minor capsid L2) that does not interfere with virus entry into endosomes and lysosomes. This antibody neutralizes infection of the virus in a dose dependent manner.

Abstract translation: 本发明一般涉及特异性结合乳头瘤病毒（次要衣壳L2的残基36-49）表面的中和表位的抗体，其不干扰病毒进入内体和溶酶体。 该抗体以剂量依赖的方式中和病毒的感染。

公开(公告)号：WO2008085938A8

公开(公告)日：2008-12-18

申请号：PCT/US2008000190

申请日：2008-01-07

Applicant: ROSALIND FRANKLIN UNIVERSITY O ,  MENESES PATRICIO I ,  ROBERTSON ERLE S ,  NGUYEN KHA ,  LANIOSZ VALERIE

Inventor： MENESES PATRICIO I ,  ROBERTSON ERLE S ,  NGUYEN KHA ,  LANIOSZ VALERIE

IPC: A61K39/42

CPC classification number: C07K16/084 ,  A61K39/00 ,  A61K39/12 ,  C07K14/005 ,  C07K2317/76 ,  C07K2317/77 ,  C12N2710/20022 ,  C12N2710/20034

Abstract: The present invention relates generally to an antibody that binds specifically to a neutralization epitope at the surface of papillomavirus (residues 36-49 of the minor capsid L2) that does not interfere with virus entry into endosomes and lysosomes. This antibody neutralizes infection of the virus in a dose dependent manner.

Abstract translation: 本发明一般涉及特异性结合乳头瘤病毒（次要衣壳L2的残基36-49）表面的中和表位的抗体，其不干扰病毒进入内体和溶酶体。 该抗体以剂量依赖的方式中和病毒的感染。