公开(公告)号：WO2009015908A3

公开(公告)日：2009-02-05

申请号：PCT/EP2008/006451

申请日：2008-07-25

Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT ,  MORPHOSYS AG ,  PETRUL, Heike ,  MENRAD, Andrease ,  WILLUDA, Jörg ,  ZOPF, Dieter ,  GLIENKE, Jens ,  PRASSLER, Josef ,  POPP, Andreas ,  STEIDL, Stefan ,  PRACHT, Catrin

Inventor： PETRUL, Heike ,  MENRAD, Andrease ,  WILLUDA, Jörg ,  ZOPF, Dieter ,  GLIENKE, Jens ,  PRASSLER, Josef ,  POPP, Andreas ,  STEIDL, Stefan ,  PRACHT, Catrin

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395

Abstract: The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy.

公开(公告)号：WO2009015908A2

公开(公告)日：2009-02-05

申请号：PCT/EP2008006451

申请日：2008-07-25

Applicant: BAYER SCHERING PHARMA AG ,  MORPHOSYS AG ,  PETRUL HEIKE ,  MENRAD ANDREASE ,  WILLUDA JOERG ,  ZOPF DIETER ,  GLIENKE JENS ,  PRASSLER JOSEF ,  POPP ANDREAS ,  STEIDL STEFAN ,  PRACHT CATRIN

Inventor： PETRUL HEIKE ,  MENRAD ANDREASE ,  WILLUDA JOERG ,  ZOPF DIETER ,  GLIENKE JENS ,  PRASSLER JOSEF ,  POPP ANDREAS ,  STEIDL STEFAN ,  PRACHT CATRIN

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/30

CPC classification number: C07K16/2866 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy.

Abstract translation: 本发明涉及特异性识别包含重链和轻链的EphB4受体的抗体和抗体片段，其包含轻链和重链CDR，以及它们作为用于治疗病理性血管生成，特别是癌症治疗的药物的用途。