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公开(公告)号：WO2011097412A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023647
申请日：2011-02-03
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WHITESIDES, George, M. , MIRICA, Katherine, A. , MARTINEZ, Andres, W. , CHENG, Chao-Min , PHILLIPS, Scott, T. , MASCAREÑAS, Monica , LIU, Xinyu , LI, Xiujun
Inventor： WHITESIDES, George, M. , MIRICA, Katherine, A. , MARTINEZ, Andres, W. , CHENG, Chao-Min , PHILLIPS, Scott, T. , MASCAREÑAS, Monica , LIU, Xinyu , LI, Xiujun
IPC: B01L3/00
CPC classification number: B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
Abstract: The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
Abstract translation: 本公开提供了用于执行多重测定的低成本便携式三维装置。 这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。
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公开(公告)号：WO2013044089A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/056655
申请日：2012-09-21
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WHITESIDES, George, M. , LAROMAINE SAGUE, Anna , DERDA, Ratmir , MACE, Charles, R. , MIRICA, Katherine, A , CECCO, Alfonso, Reina , HULME, Suzanne
Inventor： WHITESIDES, George, M. , LAROMAINE SAGUE, Anna , DERDA, Ratmir , MACE, Charles, R. , MIRICA, Katherine, A , CECCO, Alfonso, Reina , HULME, Suzanne
CPC classification number: G01N33/5085 , B03C1/288 , B03C2201/18 , G01N9/00 , G01N15/10 , G01N15/1031 , G01N33/5082 , G01N33/5088 , G01N2015/1043
Abstract: A device and methods for detecting the effect of compounds on an organism are provided. Furthermore, the device and methods disclosed herein allow for the fractionation of complex samples and the isolation of one or more organisms for the samples. The device and methods also allow for the study of development of the organism.
Abstract translation: 提供了一种用于检测化合物对生物体的影响的装置和方法。 此外，本文公开的装置和方法允许复杂样品的分级和用于样品的一种或多种生物体的分离。 该装置和方法还允许研究生物体的发育。
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公开(公告)号：WO2009121037A3
公开(公告)日：2009-12-17
申请号：PCT/US2009038693
申请日：2009-03-27
Applicant: HARVARD COLLEGE , CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
Inventor： CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
CPC classification number: B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
Abstract: Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
Abstract translation: 描述了包括由多个图案化的多孔亲水层和设置在每两个相邻的图案化多孔亲水层之间的流体不可渗透层的三维微流体装置。 每个图案化的多孔亲水层具有流体不可渗透的屏障，其基本上渗透多孔亲水层的厚度并限定图案化多孔亲水层内的一个或多个亲水区域的边界。 不透流体层具有与至少一个相邻图案化多孔亲水层内的亲水区域的至少一部分对齐的开口。 还描述了微流体测定装置，微流体混合器，微流体控制装置。
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公开(公告)号：WO2009006409A3
公开(公告)日：2009-01-08
申请号：PCT/US2008/068797
申请日：2008-06-30
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , PHILLIPS, Scott, T. , WHITESIDES, George, M. , MIRICA, Katherine, A. , CARRILHO, Emanuel , MARTINEZ, Andres, W. , SHEVKOPLYAS, Sergey, S. , SNYDER, Phillip, W. , PEREZ-CASTILLEJOS, Raquel , GUPTA, Malancha , WINKLEMAN, Adam , GUDIKSEN, Katherine, L.
Inventor： PHILLIPS, Scott, T. , WHITESIDES, George, M. , MIRICA, Katherine, A. , CARRILHO, Emanuel , MARTINEZ, Andres, W. , SHEVKOPLYAS, Sergey, S. , SNYDER, Phillip, W. , PEREZ-CASTILLEJOS, Raquel , GUPTA, Malancha , WINKLEMAN, Adam , GUDIKSEN, Katherine, L.
IPC: B01D35/06
Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
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5.发明申请DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS 审中-公开基于密度的方法分离材料，监测固体支撑反应和测量小液体体积和固体密度
公开(公告)号：WO2009006409A2
公开(公告)日：2009-01-08
申请号：PCT/US2008068797
申请日：2008-06-30
Applicant: HARVARD COLLEGE , PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L
Inventor： PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L
IPC: G01N33/53
CPC classification number: G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
Abstract translation: 描述了悬浮在使用不均匀磁场的含有顺磁性阳离子的溶液中的反磁性粒子悬浮，分离和检测密度变化的能力。 该分离装置的主要优点是：i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）它与简单的光学检测兼容（只要透明材料用于制造分离发生的容器/通道; iii）收集分离的颗粒以便进一步处理是简单的; iv）它不需要磁性标记颗粒/材料; 和v）它小巧便携。 所提供的方法和试剂盒用于分离和收集不同密度的物质，用于检测感兴趣分析物的诊断，固体支持的化学反应的监测以及固体和液体混合物密度的测定。
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Patent Agency Ranking6.发明申请THREE DIMENSIONAL ASSEMBLY OF DIAMAGNETIC MATERIALS USING MAGNETIC LEVITATION 审中-公开用磁悬浮法测量三维磁性材料的组装
公开(公告)号：WO2012088119A3
公开(公告)日：2012-10-26
申请号：PCT/US2011066169
申请日：2011-12-20
Applicant: HARVARD COLLEGE , WHITESIDES GEORGE M , ILIEVSKI FILIP , ELLERBEE AUDREY , SHEVKOPLYAS SERGEY S , MIRICA KATHERINE A
Inventor： WHITESIDES GEORGE M , ILIEVSKI FILIP , ELLERBEE AUDREY , SHEVKOPLYAS SERGEY S , MIRICA KATHERINE A
CPC classification number: B23P19/04 , B03C1/01 , B03C1/288 , B03C2201/18 , B81C3/005 , B81C2203/054 , B81C2203/057 , B81C2203/058 , C30B30/04 , Y10S117/901 , Y10T29/49826
Abstract: The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (aset of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
Abstract translation: 描述了使用反磁性粒子悬浮在含有顺磁性阳离子的溶液中组装三维结构的能力。 该分离装置的主要优点是：（i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）在固定结构之后，组装好的结构可以从顺磁性溶液中去除以进一步处理; iii）组装速度快; 和iv）它小巧便携。
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7.发明申请THREE DIMENSIONAL ASSEMBLY OF DIAMAGNETIC MATERIALS USING MAGNETIC LEVITATION 审中-公开使用磁力捕获的二维材料的三维装配
公开(公告)号：WO2012088119A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/066169
申请日：2011-12-20
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WHITESIDES, George, M. , ILIEVSKI, Filip , ELLERBEE, Audrey , SHEVKOPLYAS, Sergey, S. , MIRICA, Katherine, A.
Inventor： WHITESIDES, George, M. , ILIEVSKI, Filip , ELLERBEE, Audrey , SHEVKOPLYAS, Sergey, S. , MIRICA, Katherine, A.
IPC: B82B3/00
CPC classification number: B23P19/04 , B03C1/01 , B03C1/288 , B03C2201/18 , B81C3/005 , B81C2203/054 , B81C2203/057 , B81C2203/058 , C30B30/04 , Y10S117/901 , Y10T29/49826
Abstract: The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (aset of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
Abstract translation: 描述了使用悬浮在含有顺磁阳离子的溶液中的反磁性颗粒组装三维结构的能力。 这种分离装置的主要优点是：（i）它是一种简单的设备，不需要电力（永久磁铁和重力足以使反磁性分离和收集系统工作）; ii）组装的结构可以从顺磁溶液中去除，以便在固定结构之后进一步处理; iii）装配快速; 和iv）它是小，便携。
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公开(公告)号：WO2009121037A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/038693
申请日：2009-03-27
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CARRILHO, Emanuel , MARTINEZ, Andres, W. , MIRICA, Katherine, A. , PHILLIPS, Scott, T. , SIEGEL, Adam, C. , WILEY, Benjamin , WHITESIDES, George, M.
Inventor： CARRILHO, Emanuel , MARTINEZ, Andres, W. , MIRICA, Katherine, A. , PHILLIPS, Scott, T. , SIEGEL, Adam, C. , WILEY, Benjamin , WHITESIDES, George, M.
CPC classification number: B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
Abstract: Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
Abstract translation: 描述了包括多个图案化的多孔亲水层和设置在每两个相邻的图案化的多孔亲水层之间的流体不可渗透层的三维微流体装置。 每个图案化的多孔亲水层具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定图案化的多孔亲水层内的一个或多个亲水区域的边界。 流体不可渗透层具有与至少一个相邻的图案化的多孔亲水层内的亲水区域的至少一部分对准的开口。 还描述了微流控测定装置，微流体混合器，微流控流量控制装置。
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9.发明申请LATERAL FLOW AND FLOW-THROUGH BIOASSAY BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME 审中-公开基于图形多孔介质的横向流动和流动性生物多样性，其制造方法及其使用方法
公开(公告)号：WO2008049083A3
公开(公告)日：2009-03-12
申请号：PCT/US2007081848
申请日：2007-10-18
Applicant: HARVARD COLLEGE , WHITESIDES GEORGE M , PHILLIPS SCOTT T , MARTINEZ ANDRES W , BUTTE MANISH J , WONG AMY , THOMAS SAMUEL , SINDI HAYAT , VELLA SARAH JANE , CARRILHO EMANUEL , MIRICA KATHERINE A , LIU YANYAN
Inventor： WHITESIDES GEORGE M , PHILLIPS SCOTT T , MARTINEZ ANDRES W , BUTTE MANISH J , WONG AMY , THOMAS SAMUEL , SINDI HAYAT , VELLA SARAH JANE , CARRILHO EMANUEL , MIRICA KATHERINE A , LIU YANYAN
IPC: G01N33/558
CPC classification number: G01N33/558
Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
Abstract translation: 本发明的实施方案提供了基于图案化多孔介质的横向流动和流通生物测定装置，其制备方法及其使用方法。 在一个方面，测定装置包括多孔亲水介质; 包含聚合的光致抗蚀剂的流体不透过屏障，所述屏障基本上渗透所述多孔亲水介质的厚度，并且限定所述多孔亲水介质内的测定区域的边界; 和测定区域中的测定试剂。
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10.发明申请LATERAL FLOW AND FLOW-THROUGH BIOASSAY BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME 审中-公开基于图形多孔介质的横向流动和流动性生物多样性，其制造方法及其使用方法
公开(公告)号：WO2008049083A2
公开(公告)日：2008-04-24
申请号：PCT/US2007/081848
申请日：2007-10-18
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WHITESIDES, George, M. , PHILLIPS, Scott, T. , MARTINEZ, Andres, W. , BUTTE, Manish, J. , WONG, Amy , THOMAS, Samuel , SINDI, Hayat , VELLA, Sarah, Jane , CARRILHO, Emanuel , MIRICA, Katherine, A. , LIU, Yanyan
Inventor： WHITESIDES, George, M. , PHILLIPS, Scott, T. , MARTINEZ, Andres, W. , BUTTE, Manish, J. , WONG, Amy , THOMAS, Samuel , SINDI, Hayat , VELLA, Sarah, Jane , CARRILHO, Emanuel , MIRICA, Katherine, A. , LIU, Yanyan
IPC: G01N33/558
CPC classification number: G01N33/558
Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
Abstract translation: 本发明的实施方案提供了基于图案化多孔介质的横向流动和流通生物测定装置，其制备方法及其使用方法。 在一个方面，测定装置包括多孔亲水介质; 包含聚合的光致抗蚀剂的流体不透过屏障，所述屏障基本上渗透所述多孔亲水介质的厚度，并且限定所述多孔亲水介质内的测定区域的边界; 和测定区域中的测定试剂。
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