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    SYSTEM AND METHOD FOR MICROPLATE IMAGE ANALYSIS
    4.
    发明申请
    SYSTEM AND METHOD FOR MICROPLATE IMAGE ANALYSIS 审中-公开
    微波图像分析系统与方法

    公开(公告)号：WO2009048570A1

    公开(公告)日：2009-04-16

    申请号：PCT/US2008/011581

    申请日：2008-10-08

    Applicant: CORNING INCORPORATED ,  MODAVIS, Robert A ,  ZAMBRANO, Elvis A

    Inventor： MODAVIS, Robert A ,  ZAMBRANO, Elvis A

    IPC: G01J3/28 ,  G01N21/25 ,  G01N21/55 ,  G01N21/78

    CPC classification number: G01N21/253 ,  G01N21/7743

    Abstract: A system and a method for scan interrogation of, for example, a label-independent-detection (LID) biosensor, such as for monitoring a surface change or an event on a biosensor for use, for example, in microplate image analysis. The label-independent-detection biosensor may be reasonant waveguide (RWG) optical biosensor or a biosensor based on surface plasmon resonance (SPR). The method includes scanning a region of the biosensor including a signal area (210) and a region including a reference area (200). By searching for and selecting the most uniform sub-region (230) in these scanned areas, defects (250) can be avoided and the accuracy of the measurement is improved.

    Abstract translation: 用于例如用于监测表面变化或生物传感器上用于例如微孔板图像分析中的事件的标签无关检测（LID）生物传感器的扫描询问的系统和方法。 标签无关检测生物传感器可以是推理剂波导（RWG）光学生物传感器或基于表面等离子体共振（SPR）的生物传感器。 该方法包括扫描包括信号区域（210）的生物传感器的区域和包括参考区域（200）的区域。 通过搜索和选择这些扫描区域中最均匀的子区域（230），可以避免缺陷（250），并提高测量精度。

    OPTICAL WAVEGUIDE FIBER BRAGG GRATING
    5.
    发明申请
    OPTICAL WAVEGUIDE FIBER BRAGG GRATING 审中-公开
    光学波导光纤布拉格光栅

    公开(公告)号：WO1998006001A1

    公开(公告)日：1998-02-12

    申请号：PCT/US1997013442

    申请日：1997-07-29

    Applicant: CORNING INCORPORATED ,  MODAVIS, Robert, A.

    Inventor： CORNING INCORPORATED

    IPC: G02F01/295

    CPC classification number: G02B6/02109 ,  C03C25/62 ,  C03C25/6208

    Abstract: A method for side writing Bragg gratings, having minimal birefringence, in a waveguide structure (2) is disclosed. The method employs the orientation of the polarization direction (10) of the writing light beam (8) relative to the long axis (7) of the waveguide structure (2) together with the orientation of the intrinsic birefringence slow axis (9) to effectively minimize birefringence in the subject grating.

    Abstract translation: 公开了一种在波导结构（2）中侧面写入具有最小双折射的布拉格光栅的方法。 该方法使得相对于波导结构（2）的长轴（7）的写入光束（8）的偏振方向（10）与本征双折射慢轴（9）的取向一起有效地 最小化对象光栅中的双折射。

    MULTI-GRATING BIOSENSOR FOR LABEL-INDEPENDENT OPTICAL READERS
    6.
    发明申请
    MULTI-GRATING BIOSENSOR FOR LABEL-INDEPENDENT OPTICAL READERS 审中-公开
    用于标签独立光学读取器的多级生物传感器

    公开(公告)号：WO2011062749A1

    公开(公告)日：2011-05-26

    申请号：PCT/US2010/054944

    申请日：2010-11-01

    Applicant: CORNING INCORPORATED ,  MATEJKA, Steven R. ,  MODAVIS, Robert A. ,  PASTEL, David A. ,  PIECH, Garrett A.

    Inventor： MATEJKA, Steven R. ,  MODAVIS, Robert A. ,  PASTEL, David A. ,  PIECH, Garrett A.

    IPC: G01N21/27 ,  G01N21/77 ,  G01N21/25

    CPC classification number: G01N21/7743 ,  G01N21/253 ,  G01N21/276

    Abstract: A multi-grating resonant waveguide (RWG) biosensor for an optical reader system having a spatial resolution limit is disclosed. The multi-grating RWG biosensor includes one or more signal-grating regions and one or more reference-grating regions. The multi-grating RWG biosensor can also include a non-resonance region that spatially separates the one or more signal-grating regions, that spatially separates the one or more reference-grating regions, and that spatially separates the one or more reference-grating regions from the one or more signal-grating regions. The non-resonance region can have a minimum width greater than the optical reader system spatial resolution limit. The RWG biosensor can have an asymmetric split-grating configuration. Methods of measuring a signal resonant wavelength of a multi-grating RWG biosensor using an optical reader having a spatial resolution limit are also disclosed.

    Abstract translation: 公开了一种具有空间分辨率极限的光学读取器系统的多光栅谐振波导（RWG）生物传感器。 多光栅RWG生物传感器包括一个或多个信号光栅区域和一个或多个参考光栅区域。 多光栅RWG生物传感器还可以包括空间上分离一个或多个信号光栅区域的非共振区域，其在空间上分离一个或多个参考光栅区域，并且在空间上分离一个或多个参考光栅区域 从一个或多个信号光栅区域。 非共振区域可以具有大于光学读取器系统空间分辨率极限的最小宽度。 RWG生物传感器可以具有非对称分裂光栅配置。 还公开了使用具有空间分辨率极限的光学读取器来测量多光栅RWG生物传感器的信号谐振波长的方法。

    OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME
    7.
    发明申请
    OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME 审中-公开
    光学互连系统及其使用方法

    公开(公告)号：WO2009017637A1

    公开(公告)日：2009-02-05

    申请号：PCT/US2008/008943

    申请日：2008-07-23

    Applicant: CORNING INCORPORATED ,  MODAVIS, Robert, A. ,  WU, Qi

    Inventor： MODAVIS, Robert, A. ,  WU, Qi

    IPC: G01N21/31 ,  G01N21/47

    CPC classification number: G01N21/253 ,  G01N21/39 ,  G01N21/7743 ,  G01N2021/4742 ,  G01N2201/08

    Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

    Abstract translation: 本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。 在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。 在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。

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