公开(公告)号：WO2005017499A3

公开(公告)日：2005-08-18

申请号：PCT/US2004026225

申请日：2004-08-13

Applicant: LUMINEX CORP ,  ROTH WAYNE D ,  MOORE DOUGLAS E

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

Abstract translation: 提供了用于控制流式细胞仪型测量系统的一个或多个参数的各种方法。 一个实施例包括在样品微球的测量期间监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。

公开(公告)号：WO2005017499A8

公开(公告)日：2006-07-06

申请号：PCT/US2004026225

申请日：2004-08-13

Applicant: LUMINEX CORP ,  ROTH WAYNE D ,  MOORE DOUGLAS E

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

Abstract translation: 提供了用于控制流式细胞仪型测量系统的一个或多个参数的各种方法。 一个实施例包括在样品微球的测量期间监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。

公开(公告)号：WO2006055722A1

公开(公告)日：2006-05-26

申请号：PCT/US2005/041701

申请日：2005-11-16

Applicant: LUMINEX CORPORATION ,  MOORE, Douglas, E.

Inventor： MOORE, Douglas, E.

IPC: G01N15/14

CPC classification number: G01N15/14 ,  G01N2015/1477

Abstract: A system and method for processing sample data from a flow analyser (420) employing hardware, such as a Field Programmable Gate Array (FPGA), to process the sample data in small pipelined steps. The processing includes a circular buffer where the read and write of data is synchronous, preventing buffer overrun or data loss. This pipeline processing approach allows increasing data acquisition channels or additional processing steps without limiting processing speed.

Abstract translation: 用于处理来自采用诸如现场可编程门阵列（FPGA）之类的硬件的流量分析器（420）的采样数据以在小流水线步骤中处理采样数据的系统和方法。 处理包括一个循环缓冲区，数据的读写是同步的，防止缓冲区溢出或数据丢失。 这种流水线处理方法允许增加数据采集通道或额外的处理步骤，而不会限制处理速度。

公开(公告)号：WO2006055722A9

公开(公告)日：2006-11-09

申请号：PCT/US2005041701

申请日：2005-11-16

Applicant: LUMINEX CORP ,  MOORE DOUGLAS E

Inventor： MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/14 ,  G01N2015/1477

Abstract: A system and method for processing sample data from a flow analyser (420) employing hardware, such as a Field Programmable Gate Array (FPGA), to process the sample data in small pipelined steps. The processing includes a circular buffer where the read and write of data is synchronous, preventing buffer overrun or data loss. This pipeline processing approach allows increasing data acquisition channels or additional processing steps without limiting processing speed.

Abstract translation: 一种用于从采用诸如现场可编程门阵列（FPGA）之类的硬件的流量分析器（420）处理样本数据的系统和方法，用于以小流水线步骤处理样本数据。 该处理包括循环缓冲器，其中数据的读取和写入是同步的，防止缓冲区溢出或数据丢失。 该流水线处理方法允许增加数据采集通道或附加处理步骤而不限制处理速度。

公开(公告)号：WO2006055722B1

公开(公告)日：2006-07-27

申请号：PCT/US2005041701

申请日：2005-11-16

Applicant: LUMINEX CORP ,  MOORE DOUGLAS E

Inventor： MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/14 ,  G01N2015/1477

Abstract: A system and method for processing sample data from a flow analyser (420) employing hardware, such as a Field Programmable Gate Array (FPGA), to process the sample data in small pipelined steps. The processing includes a circular buffer where the read and write of data is synchronous, preventing buffer overrun or data loss. This pipeline processing approach allows increasing data acquisition channels or additional processing steps without limiting processing speed.

Abstract translation: 一种用于处理来自采用诸如现场可编程门阵列（FPGA）之类的硬件的流量分析器（420）的采样数据以在小流水线步骤中处理采样数据的系统和方法。 处理包括一个循环缓冲区，数据的读写是同步的，防止缓冲区溢出或数据丢失。 这种流水线处理方法允许增加数据采集通道或额外的处理步骤而不限制处理速度。

公开(公告)号：WO2005017499A2

公开(公告)日：2005-02-24

申请号：PCT/US2004/026225

申请日：2004-08-11

Applicant: LUMINEX CORPORATION ,  ROTH, Wayne, D. ,  MOORE, Douglas, E.

Inventor： ROTH, Wayne, D. ,  MOORE, Douglas, E.

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

Abstract translation: 提供了用于控制流式细胞仪类型测量系统的一个或多个参数的各种方法。 一个实施例包括在测量样本微球体期间监测测量系统的参数。 该方法还包括基于监测实时改变参数。 另一种方法包括监测接近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体的温度，其中设置有样本微球体。 该方法还包括根据温度下流体的粘度确定测量系统中的样品微球的速度。