公开(公告)号：US07790404B2

公开(公告)日：2010-09-07

申请号：US10222772

申请日：2002-08-16

Applicant: Stuart A. Lipton ,  Dongxian Zhang ,  Jon E. Chatterton ,  Kevin A Sevarino ,  Marc Awobuluyi

Inventor： Stuart A. Lipton ,  Dongxian Zhang ,  Jon E. Chatterton ,  Kevin A Sevarino ,  Marc Awobuluyi

IPC: G01N33/566 ,  C07K14/705

CPC classification number: C07K14/70571 ,  C07H21/04

Abstract: The invention provides isolated N-methyl-D-aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B or NR3A polypeptides. Further provided are methods for detecting excitatory glycine receptor ligands, agonists and antagonists. The invention also provides related diagnostic and therapeutic methods.

Abstract translation: 本发明提供分离的N-甲基-D-天冬氨酸3B型（NR3B）多肽，功能片段和肽，编码核酸分子和多核苷酸以及特异性抗体。 还提供了含有NR3B或NR3A多肽的兴奋性甘氨酸受体。 还提供了检测兴奋性甘氨酸受体配体，激动剂和拮抗剂的方法。 本发明还提供了相关的诊断和治疗方法。

公开(公告)号：US08193315B2

公开(公告)日：2012-06-05

申请号：US12842974

申请日：2010-07-23

Applicant: Stuart A. Lipton ,  Dongxian Zhang ,  Jon E. Chatterton ,  Kevin A. Sevarino ,  Marc Awobuluyi

Inventor： Stuart A. Lipton ,  Dongxian Zhang ,  Jon E. Chatterton ,  Kevin A. Sevarino ,  Marc Awobuluyi

IPC: C07K14/705

CPC classification number: C07K14/70571 ,  C07H21/04

Abstract: The invention provides isolated N-methyl-D-aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B or NR3A polypeptides. Further provided are methods for detecting excitatory glycine receptor ligands, agonists and antagonists. The invention also provides related diagnostic and therapeutic methods.

Abstract translation: 本发明提供分离的N-甲基-D-天冬氨酸3B型（NR3B）多肽，功能片段和肽，编码核酸分子和多核苷酸以及特异性抗体。 还提供了含有NR3B或NR3A多肽的兴奋性甘氨酸受体。 还提供了检测兴奋性甘氨酸受体配体，激动剂和拮抗剂的方法。 本发明还提供了相关的诊断和治疗方法。

公开(公告)号：US20110045098A1

公开(公告)日：2011-02-24

申请号：US12842974

申请日：2010-07-23

Applicant: STUART A. LIPTON ,  DONGXIAN ZHANG ,  JON E. CHATTERTON ,  KEVIN A. SEVARINO ,  MARC AWOBULUYI

Inventor： STUART A. LIPTON ,  DONGXIAN ZHANG ,  JON E. CHATTERTON ,  KEVIN A. SEVARINO ,  MARC AWOBULUYI

IPC: A61K35/12 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  C07K14/705 ,  A61K38/17 ,  C12P21/06

CPC classification number: C07K14/70571 ,  C07H21/04

Abstract: The invention provides isolated N-methyl-D-aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B or NR3A polypeptides. Further provided are methods for detecting excitatory glycine receptor ligands, agonists and antagonists. The invention also provides related diagnostic and therapeutic methods.

Abstract translation: 本发明提供分离的N-甲基-D-天冬氨酸3B型（NR3B）多肽，功能片段和肽，编码核酸分子和多核苷酸以及特异性抗体。 还提供了含有NR3B或NR3A多肽的兴奋性甘氨酸受体。 还提供了检测兴奋性甘氨酸受体配体，激动剂和拮抗剂的方法。 本发明还提供了相关的诊断和治疗方法。