公开(公告)号：US20230405104A1

公开(公告)日：2023-12-21

申请号：US18032784

申请日：2021-10-19

Applicant: Shanghai Reinovax Biologics Co., Ltd ,  Shanghai Microdom Biotech Co., Ltd

Inventor： Xianchao ZHU ,  Huagen CHEN ,  Xishuang XIONG ,  Ying LI ,  Juanjuan WANG ,  Chang LIU ,  Qingfeng XIA ,  Yizhi MAO ,  Zhu WANG ,  Enhua SHEN

IPC: A61K39/09 ,  C07K14/33 ,  A61K39/385 ,  A61P31/04

CPC classification number: A61K39/092 ,  C07K14/33 ,  A61K2039/6037 ,  A61P31/04 ,  A61K39/385

Abstract: Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.

公开(公告)号：AT441117T

公开(公告)日：2009-09-15

申请号：AT02702458

申请日：2002-02-06

Applicant: MICRODOM

Inventor： THERRY FRANCIS ,  LEBOEUF JEAN-PIERRE

IPC: G01N35/08 ,  G01J3/36 ,  G01J3/42 ,  G01N1/00 ,  G01N21/05 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35

Abstract: Spectrophotometric analysis device having a feeder circuit of a test stand. The analysis device has two distinct spectrophotometers facing the same test stand, especially in order to be able to cover spectra with wavelengths that are separate and included in the wavelengths on either side of the visible range. A first spectrophotometer covers the spectrum of the near and mean infrared ranges while a second spectrophotometer covers the spectrum of the ultraviolet and visible ranges. This analysis device provides especially for the spectrophotometric determination of the different constituents contained in fluids to be analysed, such as wine, fruit juice or blood.

公开(公告)号：DE60233471D1

公开(公告)日：2009-10-08

申请号：DE60233471

申请日：2002-02-06

Applicant: MICRODOM

Inventor： THERRY FRANCIS ,  LEBOEUF JEAN-PIERRE

IPC: G01N35/08 ,  G01J3/36 ,  G01J3/42 ,  G01N1/00 ,  G01N21/05 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35

Abstract: Spectrophotometric analysis device having a feeder circuit of a test stand. The analysis device has two distinct spectrophotometers facing the same test stand, especially in order to be able to cover spectra with wavelengths that are separate and included in the wavelengths on either side of the visible range. A first spectrophotometer covers the spectrum of the near and mean infrared ranges while a second spectrophotometer covers the spectrum of the ultraviolet and visible ranges. This analysis device provides especially for the spectrophotometric determination of the different constituents contained in fluids to be analysed, such as wine, fruit juice or blood.

公开(公告)号：ES2332582T3

公开(公告)日：2010-02-09

申请号：ES02702458

申请日：2002-02-06

Applicant: MICRODOM

Inventor： THERRY FRANCIS ,  LEBOEUF JEAN-PIERRE

IPC: G01N35/08 ,  G01J3/36 ,  G01J3/42 ,  G01N1/00 ,  G01N21/05 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35

Abstract: Dispositivo (1) de análisis espectrofotométrico de un fluido (2) que incluye un primer espectrofotómetro (14) y un segundo espectrofotómetro (18), incluyendo cada uno de los espectrofotómetros respectivamente una fuente de luz (15, 19) y un detector (16, 20) dispuestos a una parte y a otra respectivamente de un primer banco de ensayo (5) y un segundo banco de ensayo (105), una primera fuente (15) de luz que emite en una primera gama de longitudes de onda en dirección al primer banco de ensayo y una segunda fuente (19) de luz que emite en una segunda gama de longitudes de onda diferente de la primera gama de longitudes de onda, en dirección al segundo banco de ensayo, caracterizado porque incluye un ordenador (22) dispuesto para tratar y correlacionar unos valores de absorbencia proporcionados por uno de los espectrofotómetros con unos valores de absorbencias proporcionados por el otro de los espectrofotómetros.

公开(公告)号：DK1358487T3

公开(公告)日：2009-12-21

申请号：DK02702458

申请日：2002-02-06

Applicant: MICRODOM

Inventor： THERRY FRANCIS ,  LEBOEUF JEAN-PIERRE

IPC: G01N35/08 ,  G01J3/36 ,  G01J3/42 ,  G01N1/00 ,  G01N21/05 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35

Abstract: Spectrophotometric analysis device having a feeder circuit of a test stand. The analysis device has two distinct spectrophotometers facing the same test stand, especially in order to be able to cover spectra with wavelengths that are separate and included in the wavelengths on either side of the visible range. A first spectrophotometer covers the spectrum of the near and mean infrared ranges while a second spectrophotometer covers the spectrum of the ultraviolet and visible ranges. This analysis device provides especially for the spectrophotometric determination of the different constituents contained in fluids to be analysed, such as wine, fruit juice or blood.

公开(公告)号：EP1358487B1

公开(公告)日：2009-08-26

申请号：EP02702458.7

申请日：2002-02-06

Applicant: Microdom

Inventor： THERRY, Francis ,  LEBOEUF, Jean-Pierre

IPC: G01N35/08 ,  G01J3/42 ,  G01N21/31

CPC classification number: G01N35/1097 ,  G01J3/36 ,  G01J3/42 ,  G01N21/05 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/359 ,  G01N33/143 ,  G01N33/146 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2201/06146

Abstract: The invention relates to a spectrophotometry analysis device (1) comprising a test bench (4) power supply circuit (4). The analysis device comprises two different spectrophotometers (14, 18) disposed opposite the same test bench in order, in particular, to cover separate wavelength spectra included in the visible wavelength range. A first spectrophotometer (14) is used to cover the close and medium infrared spectrum, while a second spectrophotometer (18) is used to cover the ultraviolet and visible spectrum. Said analysis device is particularly suitable for dosing different components contained in fluids to be analysed (2), such as wine, fruit juice or blood-stained fluid.

公开(公告)号：EP4512419A1

公开(公告)日：2025-02-26

申请号：EP23791262.1

申请日：2023-04-19

Applicant: Shanghai Reinovax Biologics Co., Ltd ,  Shanghai Microdom Biotech Co., Ltd

Inventor： ZHU, Xianchao ,  CHEN, Huagen ,  XIONG, Xishuang ,  LIU, Chang ,  LI, Ying ,  XIA, Qingfeng ,  HE, Ping ,  WANG, Juanjuan ,  HUANG, Xiaomin

IPC: A61K39/116 ,  A61K39/385 ,  A61P31/04

Abstract: The present invention relates to a polyvalent pneumococcal polysaccharide protein conjugate and immunogenicity thereof, and specifically provides an immunogenic composition containing capsular polysaccharides of streptococcus pneumoniae from different serotypes, and a carrier, the serotypes at least comprising 2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20, 22F and 33F. The immunogenic composition can improve the immunogenicity of polysaccharides of different serotypes, and may prevent invasive infection caused by pneumococci of various different serotypes.

公开(公告)号：EP4234572A1

公开(公告)日：2023-08-30

申请号：EP21882001.7

申请日：2021-10-19

Applicant: Shanghai Reinovax Biologics Co., Ltd ,  Shanghai Microdom Biotech Co., Ltd

Inventor： ZHU, Xianchao ,  CHEN, Huagen ,  XIONG, Xishuang ,  LI, Ying ,  WANG, Juanjuan ,  LIU, Chang ,  XIA, Qingfeng ,  MAO, Yizhi ,  WANG, Zhu ,  SHEN, Enhua

IPC: C07K14/195 ,  A61K39/09 ,  A61K39/385 ,  A61P31/04 ,  A61P11/00

Abstract: Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.