公开(公告)号：JP2021535185A

公开(公告)日：2021-12-16

申请号：JP2021512615

申请日：2019-09-06

Applicant: アカデミア シニカ ,  ACADEMIA SINICA ,  ミン−チェ・シー ,  Ming−Che Shih

Inventor： マー・チェ ,  リウ・ヨー−ミン ,  ジャン・ジア−ツロン

IPC: C07K14/42 ,  A61K36/48 ,  A61P31/16 ,  A61K38/16

Abstract: 本発明は、抗ウイルスレクチンおよびその使用に関する。特に、本発明は、インフルエンザウイルス感染を処置または予防することにおける使用のための複合型(CX型)および/またはハイブリッド型(HY型)グリカン結合レクチンに関する。本発明はまた、処置または予防を必要とする対象体に前記レクチンまたはそれを含む組成物を投与することにより、インフルエンザウイルス感染を処置または予防するための方法も提供する。

公开(公告)号：US20230235007A1

公开(公告)日：2023-07-27

申请号：US18001947

申请日：2021-06-15

Applicant: Ming-Che SHIH ,  ACADEMIA SINICA ,  NATIONAL TAIWAN UNIVERSITY

Inventor： Pan-Chyr YANG ,  Sui-Yuan CHANG ,  Kuo-Yen HUANG

IPC: C07K14/705 ,  A61K47/64 ,  A61P31/14 ,  C07K14/55 ,  A61K38/20 ,  A61K38/17 ,  A61K45/06

CPC classification number: C07K14/705 ,  A61K47/642 ,  A61K47/6425 ,  A61P31/14 ,  C07K14/55 ,  A61K38/2013 ,  A61K38/177 ,  A61K45/06 ,  C07K2319/30 ,  C07K2319/02

Abstract: Disclosed herein are ACE2-Fc fusion polypeptides that contain at least one binding site for a spike protein of a coronavirus and methods of using such for therapeutic and/or diagnostic purposes. Also provided herein are methods for producing such fusion polypeptides.

公开(公告)号：US20210379151A1

公开(公告)日：2021-12-09

申请号：US17282514

申请日：2019-10-02

Applicant: Ming-Che Shih ,  ACADEMIA SINICA

Inventor： Patrick C.H. Hsieh ,  David Lundy

IPC: A61K38/18 ,  A61K31/704 ,  A61P35/00 ,  A61K9/00

Abstract: A method of facilitating the delivery of an agent across the blood-brain barrier (BBB) of a subject, the method involving the use of a low dose of vascular endothelial growth factor (VEGF) polypeptide. In some embodiments, the VEGF polypeptide can be given to the subject before and after administration of the agent at multiple doses.

公开(公告)号：US08703474B2

公开(公告)日：2014-04-22

申请号：US13210637

申请日：2011-08-16

Applicant: Jui-Jen Chang ,  Cheng-Yu Ho ,  Chieh-Chen Huang ,  Ming-Che Shih ,  Wen-Hsiung Li

Inventor： Jui-Jen Chang ,  Cheng-Yu Ho ,  Chieh-Chen Huang ,  Ming-Che Shih ,  Wen-Hsiung Li

IPC: C12N1/16 ,  A61K38/00

CPC classification number: C12R1/645 ,  C12P7/22 ,  C12P7/62 ,  C12P7/6436

Abstract: Disclosed are a novel flavor compound-producing yeast strain and methods of using the strain to produce flavor compounds.

Abstract translation: 公开了一种新颖的产生风味化合物的酵母菌株和使用该菌株产生风味化合物的方法。

公开(公告)号：US20230160892A1

公开(公告)日：2023-05-25

申请号：US17913986

申请日：2021-03-22

Applicant: Ming-Che SHIH ,  Academia Sinica

Inventor： Yu-Chan CHAO ,  Sung-Chan WEI ,  Huei-Ru LO ,  Chih-Hsuan TSAI ,  Yu-Wen LO ,  Wei-Ting HSU ,  Chuan-Yu LIAO

IPC: G01N33/569 ,  C12N15/86 ,  C07K14/435 ,  C07K14/005

CPC classification number: G01N33/56983 ,  C12N15/86 ,  C07K14/43572 ,  C07K14/005 ,  C12N2710/14022 ,  C12N2710/14042 ,  C12N2710/14052 ,  C12N2770/20034 ,  G01N2469/20 ,  A61K39/00

Abstract: Disclosed herein are recombinant viruses and/or insect cells suitable for detecting the infection of a pathogen in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the pathogen or not, so that proper course of treatment may be assigned to the subject. Also disclosed herein is a vaccine for the prophylaxis and/or treatment of infection caused by said pathogen.

公开(公告)号：US09340794B2

公开(公告)日：2016-05-17

申请号：US13601146

申请日：2012-08-31

Applicant: Jui-Jen Chang ,  Feng-Ju Ho ,  Cheng-Yu Ho ,  Wen-Hsiung Li ,  Ming-Che Shih ,  Chieh-Chen Huang

Inventor： Jui-Jen Chang ,  Feng-Ju Ho ,  Cheng-Yu Ho ,  Wen-Hsiung Li ,  Ming-Che Shih ,  Chieh-Chen Huang

IPC: C12N15/66 ,  C12N15/81

CPC classification number: C12N15/815

Abstract: Described is a method of introducing multiple nucleic acid molecules into the genome of a cell. The method includes providing a plurality of nucleic acid molecules, each of the plurality of nucleic acid molecules containing (a) a nucleic acid sequence operatively linked to a promoter sequence at the 5′ end of the nucleic acid molecule, and (b) an overlapping sequence at the 3′ end of the nucleic acid molecule.

Abstract translation: 描述了将多个核酸分子引入细胞的基因组中的方法。 所述方法包括提供多个核酸分子，所述多个核酸分子中的每一个含有（a）与所述核酸分子的5'末端的启动子序列可操作地连接的核酸序列，和（b）重叠 序列在核酸分子的3'末端。

公开(公告)号：US20140248703A1

公开(公告)日：2014-09-04

申请号：US13601146

申请日：2012-08-31

Applicant: Jui-Jen Chang ,  Feng-Ju Ho ,  Cheng-Yu Ho ,  Wen-Hsiung Li ,  Ming-Che Shih ,  Chieh-Chen Huang

Inventor： Jui-Jen Chang ,  Feng-Ju Ho ,  Cheng-Yu Ho ,  Wen-Hsiung Li ,  Ming-Che Shih ,  Chieh-Chen Huang

IPC: C12N15/81

CPC classification number: C12N15/815

Abstract: Described is a method of introducing multiple nucleic acid molecules into the genome of a cell. The method includes providing a plurality of nucleic acid molecules, each of the plurality of nucleic acid molecules containing (a) a nucleic acid sequence operatively linked to a promoter sequence at the 5′ end of the nucleic acid molecule, and (b) an overlapping sequence at the 3′ end of the nucleic acid molecule.

Abstract translation: 描述了将多个核酸分子引入细胞基因组的方法。 所述方法包括提供多个核酸分子，所述多个核酸分子中的每一个含有（a）与所述核酸分子的5'末端的启动子序列可操作地连接的核酸序列，和（b）重叠 序列在核酸分子的3'末端。

公开(公告)号：US08431371B2

公开(公告)日：2013-04-30

申请号：US13306056

申请日：2011-11-29

Applicant: Wen-Hsiung Li ,  Ming-Che Shih ,  Chieh-Chen Huang ,  Jui-Jen Chang ,  Cheng-Yu Ho

Inventor： Wen-Hsiung Li ,  Ming-Che Shih ,  Chieh-Chen Huang ,  Jui-Jen Chang ,  Cheng-Yu Ho

IPC: C12P7/16 ,  C12P7/10 ,  C12P7/06

CPC classification number: C07K14/33 ,  C12N1/22 ,  C12N9/00 ,  C12N9/244 ,  C12N15/63 ,  C12N15/75 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01006 ,  Y02E50/16 ,  Y02E50/17

Abstract: An expression system for producing a multi-enzyme complex, the system including a nucleic acid molecule containing a promoter operatively linked to a nucleotide sequence including multiple genes encoding multiple enzymes that are components of the multi-enzyme complex.

Abstract translation: 一种用于产生多酶复合物的表达系统，该系统包含含有可操作地连接到核苷酸序列的启动子的核酸分子，该核苷酸序列包括编码作为多酶复合物的组分的多种酶的多个基因。

公开(公告)号：US20120083012A1

公开(公告)日：2012-04-05

申请号：US13306056

申请日：2011-11-29

Applicant: Jui-Jen Chang ,  Cheng-Yu Ho ,  Ming-Che Shih ,  Chieh-Chen Huang ,  Wen-Hsiung Li

Inventor： Jui-Jen Chang ,  Cheng-Yu Ho ,  Ming-Che Shih ,  Chieh-Chen Huang ,  Wen-Hsiung Li

IPC: C12N9/96 ,  C12P1/00 ,  C12N1/13 ,  C12N1/19 ,  C12N15/63 ,  C12N1/21

CPC classification number: C07K14/33 ,  C12N1/22 ,  C12N9/00 ,  C12N9/244 ,  C12N15/63 ,  C12N15/75 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01006 ,  Y02E50/16 ,  Y02E50/17

Abstract: An expression system for producing a multi-enzyme complex, the system including a nucleic acid molecule containing a promoter operatively linked to a nucleotide sequence including multiple genes encoding multiple enzymes that are components of the multi-enzyme complex.

Abstract translation: 一种用于产生多酶复合物的表达系统，该系统包含含有可操作地连接到核苷酸序列的启动子的核酸分子，该核苷酸序列包括编码作为多酶复合物的组分的多种酶的多个基因。

公开(公告)号：US20230184751A1

公开(公告)日：2023-06-15

申请号：US17925119

申请日：2021-05-14

Applicant: Ming-Che SHIH ,  ACADEMIA SINICA

Inventor： Wen-Bin YANG

IPC: G01N33/53 ,  G01N30/72 ,  G01N33/58

CPC classification number: G01N33/5308 ,  G01N30/7233 ,  G01N33/58 ,  G01N2030/027

Abstract: The present invention relates to a system and method for carbohydrate analysis in a flow chemistry manner. The present invention at least features continuous reactions of glycan hydrolysis in combination with saccharide labeling which is helpful to improve the existing approaches in glycan structural analysis.