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    composições farmacêuticas compreendendo derivados de poh
    1.
    发明专利
    composições farmacêuticas compreendendo derivados de poh 未知

    公开(公告)号：BR112013004698A2

    公开(公告)日：2016-05-10

    申请号：BR112013004698

    申请日：2011-08-26

    Applicant: NEONC TECHNOLOGIES INC

    Inventor： LEVIN DANIEL ,  PUPALLI SATISH ,  CHEN THOMAS

    IPC: C07C35/18

    Abstract: composições farmacêuticas compreendendo derivados de poh. a presente invenção proporciona um derivado de monoterpeno ou sesquiterpeno, tal como um derivado de álcool perílico. por exemplo, o derivado de álcool perílico pode ser um carbamento de álcool perílico. o derivado de álcool perílico pode ser álcool perílilo conjugado com um agente terapêutico tal como um agente quimioterapêutico. a presente invenção também proporciona um método de tratar uma doença tal como câncer, compreendendo a etapa de enviar a um paciente uma quantidade terapeuticamente eficaz de um derivado de monoterpeno (ou sesquiterpeno). a via de administração pode variar, e pode incluir inalação, intranasal, oral, transdérmica, intravenosa, subcutânea ou injeção intramuscular.

    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES
    3.
    发明专利
    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES 未知

    公开(公告)号：CA2828833A1

    公开(公告)日：2011-09-09

    申请号：CA2828833

    申请日：2011-03-03

    Applicant: NEONC TECHNOLOGIES INC

    Inventor： CHEN THOMAS ,  LEVIN DANIEL ,  PUPPALI SATISH

    IPC: A01N43/78 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/635 ,  A61P35/00

    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w) The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w) The purified monoterpene can be used to treat a disease such as cancer The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

    PHARMACEUTICAL COMPOSITIONS COMPRISING DEUTERIUM-ENRICHED PERILLYL ALCOHOL, ISO-PERILLYL ALCOHOL AND DERIVATIVES THEREOF
    4.
    发明专利
    PHARMACEUTICAL COMPOSITIONS COMPRISING DEUTERIUM-ENRICHED PERILLYL ALCOHOL, ISO-PERILLYL ALCOHOL AND DERIVATIVES THEREOF 未知

    公开(公告)号：CA2856403A1

    公开(公告)日：2013-08-15

    申请号：CA2856403

    申请日：2012-11-21

    Applicant: NEONC TECHNOLOGIES INC

    Inventor： CHEN THOMAS ,  LEVIN DANIEL ,  PUPALLI SATISH

    IPC: C07C33/14 ,  A61K31/045 ,  A61K47/48 ,  A61P35/00

    Abstract: The present invention, provides for a deuterium-enriched monoterpene or sesquiterpene such as perillyl alcohol, or a deuterium-enriched isomer or analog of monoterpenes or sesquiterpenes, such as isoperillyl alcohol. The present invention also provides for a deuterium-enriched derivative of a monoterpene or sesquiterpene, such as a perillyl alcohol carbamate, or a deuterium-enriched derivative of an isomer or analog of a monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The deuterium-enriched derivative may be perillyl alcohol or isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a deuterium-enriched compound.

    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES
    5.
    发明专利
    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES 未知

    公开(公告)号：HK1210767A1

    公开(公告)日：2016-05-06

    申请号：HK15111511

    申请日：2015-11-20

    Applicant: NEONC TECHNOLOGIES INC

    Inventor： CHEN THOMAS T ,  LEVIN DANIEL D ,  PUPPALI SATISH S

    IPC: C07C20060101

    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w) The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w) The purified monoterpene can be used to treat a disease such as cancer The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

    PHARMACEUTICAL COMPOSITIONS COMPRISING DEUTERIUM-ENRICHED PERILLYL ALCOHOL, ISO-PERILLYL ALCOHOL AND DERIVATIVES THEREOF
    10.
    发明申请
    PHARMACEUTICAL COMPOSITIONS COMPRISING DEUTERIUM-ENRICHED PERILLYL ALCOHOL, ISO-PERILLYL ALCOHOL AND DERIVATIVES THEREOF 审中-公开
    包含富含氘的胭脂红醇，异癸醇及其衍生物的药物组合物

    公开(公告)号：WO2013119304A2

    公开(公告)日：2013-08-15

    申请号：PCT/US2012/066379

    申请日：2012-11-21

    Applicant: NEONC TECHNOLOGIES INC.

    Inventor： CHEN, Thomas ,  LEVIN, Daniel ,  PUPALLI, Satish

    IPC: A61K47/48 ,  A61K45/06 ,  A61N5/10

    CPC classification number: A61K45/06 ,  A61K31/05 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K47/54 ,  A61N5/10 ,  A61N2005/1098 ,  A61K2300/00

    Abstract: The present invention, provides for a deuterium-enriched monoterpene or sesquiterpene such as perillyl alcohol, or a deuterium-enriched isomer or analog of monoterpenes or sesquiterpenes, such as isoperillyl alcohol. The present invention also provides for a deuterium-enriched derivative of a monoterpene or sesquiterpene, such as a perillyl alcohol carbamate, or a deuterium-enriched derivative of an isomer or analog of a monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The deuterium-enriched derivative may be perillyl alcohol or isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a deuterium-enriched compound.

    Abstract translation: 本发明提供富含氘的单萜或倍半萜如紫苏醇，或富氘异构体或单萜或倍半萜的类似物，如异紫苏醇。 本发明还提供了一种用于单萜或倍半萜的氘富集的衍生物如紫苏醇氨基甲酸酯，或其异构体或单萜或倍半萜，模拟的氘富集的衍生物如异紫苏醇氨基甲酸酯。 富含氘的衍生物可以是与治疗剂例如化学治疗剂缀合的紫苏醇或异紫苏醇。 本发明还提供了治疗诸如癌症的疾病的方法，包括向患者递送治疗有效量的富含氘的化合物的步骤。

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