公开(公告)号：US20040157073A1

公开(公告)日：2004-08-12

申请号：US10772672

申请日：2004-02-05

Applicant: Nucryst Pharmaceuticals Corp., a Alberta, Canada corporation

Inventor： Robert Edward Burrell ,  Hua Qing Yin ,  Antony George Naylor ,  Peter Howard Moxham ,  Walter Carlton Theodore Cholowski ,  Leonard Salvin Bowlby ,  David James Field

IPC: C23C020/00

CPC classification number: A61K9/0024 ,  A01N59/16 ,  A61K9/0019 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/14 ,  A61K9/7007 ,  A61K33/24 ,  A61K33/38 ,  A61K33/40 ,  A61K47/34 ,  A61K47/38 ,  A61L15/46 ,  A61L17/145 ,  A61L27/30 ,  A61L29/10 ,  A61L31/082 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/452 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2300/63 ,  Y10S424/15 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/829 ,  Y10S514/83 ,  Y10S514/849 ,  Y10S514/851 ,  Y10S514/853 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/864 ,  Y10S514/865 ,  Y10S514/88 ,  Y10S514/881 ,  Y10S514/882 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902 ,  Y10S514/912 ,  Y10S514/914 ,  Y10S514/925 ,  Y10S514/931 ,  Y10S514/932 ,  Y10S514/933 ,  Y10S514/934 ,  Y10S514/944 ,  Y10S514/951 ,  Y10S514/953 ,  Y10S514/954 ,  Y10S514/956 ,  Y10S514/958 ,  Y10S514/964 ,  Y10S514/965 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968 ,  Y10S514/969 ,  Y10T428/31855 ,  A61K2300/00 ,  A01N25/04 ,  A01N25/10 ,  A01N25/12

Abstract: The invention provides methods and kits to form water swellable gel coatings, preferably lubricious coatings, on substrates, and coated substrates thus formed. The coatings contain one or more antimicrobial metals formed with atomic disorder, together with one or more antimicrobial metals formed with atomic disorder such that the coatings provide an antimicrobial and anti-inflammatory effect when wet. The invention also provides a method to produce metal powders by sputtering a coating onto a moving surface, and then scraping the coating with one or more scrapers to produce the metal powder. The method is particularly useful for producing large amounts of nanocrystalline antimicrobial metal powders formed with atomic disorder, useful in the water swellable gel coatings of this invention.

公开(公告)号：WO2006016263A2

公开(公告)日：2006-02-16

申请号：PCT/IB2005/002459

申请日：2005-03-03

Applicant: NUCRYST PHARMACEUTICALS CORP. ,  STILES, James, Alexander, Robert ,  FIELD, David, James

Inventor： STILES, James, Alexander, Robert ,  FIELD, David, James

IPC: A61K33/38

CPC classification number: A61K33/00 ,  A61K33/38 ,  B82Y5/00

Abstract: NO-containing complexes, as well as methods of making and using such complexes are disclosed.

Abstract translation: 公开了含NO复合物，以及制备和使用这种复合物的方法。

公开(公告)号：WO2002085387A2

公开(公告)日：2002-10-31

申请号：PCT/CA2002/000549

申请日：2002-04-23

Applicant: NUCRYST PHARMACEUTICALS CORP. ,  BURRELL, Robert, Edward ,  YIN, Hua, Qing

Inventor： BURRELL, Robert, Edward ,  YIN, Hua, Qing

IPC: A61K33/00

CPC classification number: A61K9/0024 ,  A01N59/16 ,  A61K9/0019 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/14 ,  A61K9/7007 ,  A61K33/24 ,  A61K33/38 ,  A61K33/40 ,  A61K47/34 ,  A61K47/38 ,  A61L15/46 ,  A61L17/145 ,  A61L27/30 ,  A61L29/10 ,  A61L31/082 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/452 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2300/63 ,  Y10S424/15 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/829 ,  Y10S514/83 ,  Y10S514/849 ,  Y10S514/851 ,  Y10S514/853 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/864 ,  Y10S514/865 ,  Y10S514/88 ,  Y10S514/881 ,  Y10S514/882 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902 ,  Y10S514/912 ,  Y10S514/914 ,  Y10S514/925 ,  Y10S514/931 ,  Y10S514/932 ,  Y10S514/933 ,  Y10S514/934 ,  Y10S514/944 ,  Y10S514/951 ,  Y10S514/953 ,  Y10S514/954 ,  Y10S514/956 ,  Y10S514/958 ,  Y10S514/964 ,  Y10S514/965 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968 ,  Y10S514/969 ,  Y10T428/31855 ,  A61K2300/00 ,  A01N25/04 ,  A01N25/10 ,  A01N25/12

Abstract: The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form,for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choise may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.

Abstract translation: 本发明涉及一种或多种抗微生物金属，最优选银，优选以原子紊乱形成，优选以纳米晶形式用于治疗炎性皮肤病症的用途。 选择的纳米晶体抗微生物金属可以以一种或多种抗微生物金属的纳米晶体涂层的形式使用，一种或多种抗微生物金属的纳米晶体粉末，或含有来自纳米晶体粉末或一种或多种抗微生物剂的纳米晶体粉末的溶解物质的溶液 金属。

公开(公告)号：WO2009014781A2

公开(公告)日：2009-01-29

申请号：PCT/US2008/061597

申请日：2008-04-25

Applicant: NUCRYST PHARMACEUTICALS CORP. ,  LYCZAK, Jeffrey B. ,  THOMPSON, Katherine

Inventor： LYCZAK, Jeffrey B. ,  THOMPSON, Katherine

IPC: A01N59/16 ,  A01P1/00

CPC classification number: A61K33/38 ,  A01N59/16 ,  A61K9/0056 ,  A61K9/7023 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/437 ,  A61K38/14 ,  A61K45/06 ,  B82Y5/00 ,  Y02A50/469 ,  Y10S977/773 ,  Y10S977/915 ,  A01N25/12 ,  A01N25/26 ,  A01N25/34 ,  A01N2300/00 ,  A61K2300/00

Abstract: Metal-containing materials, as well as their preparation, formulations, and use are disclosed.

Abstract translation: 公开了含金属材料及其制备，配方和用途。

公开(公告)号：WO2004037186A3

公开(公告)日：2004-05-06

申请号：PCT/US2003/033431

申请日：2003-10-22

Applicant: NUCRYST PHARMACEUTICALS CORP. ,  GILLIS, Scott, H. ,  SCHECHTER, Paul ,  DEMLING, Robert, H.

Inventor： GILLIS, Scott, H. ,  SCHECHTER, Paul ,  DEMLING, Robert, H.

IPC: A61F13/00

Abstract: Prophylactic treatment methods are disclosed. The methods can include contacting an object and/or an area of a subject with a metal-containing material to reduce the occurrence of a condition at the same area or a different area of the subject. The metals containing material can be, for example, an antimicrobial material, an anti-biofilm metal containing material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, an anti proliferative material, an MMP modulating material, an atomically disordered, crystalline material, and/or a nanocrystalline material. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.

公开(公告)号：WO2002085384A2

公开(公告)日：2002-10-31

申请号：PCT/CA2002/000546

申请日：2002-04-23

Applicant: NUCRYST PHARMACEUTICALS CORP. ,  BURRELL, Robert, Edward ,  YIN, Hua, Qing ,  NAYLOR, Antony, George ,  MOXHAM, Peter, Howard ,  CHOLOWSKI, Walter, Carlton, Theodore ,  BOWLBY, Leonard, Salvin ,  FIELD, David, James

Inventor： BURRELL, Robert, Edward ,  YIN, Hua, Qing ,  NAYLOR, Antony, George ,  MOXHAM, Peter, Howard ,  CHOLOWSKI, Walter, Carlton, Theodore ,  BOWLBY, Leonard, Salvin ,  FIELD, David, James

IPC: A61K33/00

CPC classification number: A61K9/0024 ,  A01N59/16 ,  A61K9/0019 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/14 ,  A61K9/7007 ,  A61K33/24 ,  A61K33/38 ,  A61K33/40 ,  A61K47/34 ,  A61K47/38 ,  A61L15/46 ,  A61L17/145 ,  A61L27/30 ,  A61L29/10 ,  A61L31/082 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/452 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2300/63 ,  Y10S424/15 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/829 ,  Y10S514/83 ,  Y10S514/849 ,  Y10S514/851 ,  Y10S514/853 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/864 ,  Y10S514/865 ,  Y10S514/88 ,  Y10S514/881 ,  Y10S514/882 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902 ,  Y10S514/912 ,  Y10S514/914 ,  Y10S514/925 ,  Y10S514/931 ,  Y10S514/932 ,  Y10S514/933 ,  Y10S514/934 ,  Y10S514/944 ,  Y10S514/951 ,  Y10S514/953 ,  Y10S514/954 ,  Y10S514/956 ,  Y10S514/958 ,  Y10S514/964 ,  Y10S514/965 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968 ,  Y10S514/969 ,  Y10T428/31855 ,  A61K2300/00 ,  A01N25/04 ,  A01N25/10 ,  A01N25/12

Abstract: The invention provides methods and kits to form water swellable gel coatings, preferably lubricious coatings, on substrates, and coated substrates thus formed. The coatings contain one or more antimicrobial metals formed with atomic disorder, together with one or more antimicrobial metals formed with atomic disorder such that the coatings provide an antimicrobial and anti-inflammatory effect when wet. The invention also provides a method to produce metal powders by sputtering a coating onto a moving surface, and then scraping the coating with one or more scrapers to produce the metal powder. The method is particularly useful for producing large amounts of nanocrystalline antimicrobial metal powders formed with atomic disorder, useful in the water swellable gel coatings on this invention.

Abstract translation: 本发明提供了在基底上形成水可溶胀凝胶涂层，优选润滑涂层的方法和试剂盒，以及如此形成的涂覆的基底。 涂层含有一种或多种由原子紊乱形成的抗微生物金属，以及一种或多种由原子紊乱形成的抗微生物金属，使得涂层在湿润时提供抗微生物和抗炎作用。 本发明还提供了通过将涂层溅射到移动表面上然后用一个或多个刮刀刮擦涂层以产生金属粉末来生产金属粉末的方法。 该方法特别适用于生产大量由原子紊乱形成的纳米晶体抗微生物金属粉末，可用于本发明的水溶胀性凝胶涂层。

公开(公告)号：WO2008005705A2

公开(公告)日：2008-01-10

申请号：PCT/US2007/071867

申请日：2007-06-22

Applicant: NUCRYST PHARMACEUTICALS CORP. ,  CHEN, Wen Gang ,  BHOL, Khailash ,  LYCZAK, Jeffrey B. ,  SCHECHTER, Paul

Inventor： CHEN, Wen Gang ,  BHOL, Khailash ,  LYCZAK, Jeffrey B. ,  SCHECHTER, Paul

CPC classification number: A61K9/0014 ,  A61K33/00 ,  A61K33/24 ,  A61K33/38

Abstract: Metal-containing materials, as well as their preparation, formulations, and use are disclosed.

Abstract translation: 公开了含金属材料及其制备，制剂和用途。

公开(公告)号：WO2005074949A1

公开(公告)日：2005-08-18

申请号：PCT/US2005/001043

申请日：2005-01-12

Applicant: NUCRYST PHARMACEUTICALS CORP. ,  GILLIS, Scott, H.

Inventor： GILLIS, Scott, H.

IPC: A61K33/38

CPC classification number: A61K31/28 ,  A61K9/0009 ,  A61K9/0021 ,  A61K31/496 ,  A61K31/704 ,  A61K33/38 ,  A61K47/36 ,  A61K47/38 ,  Y10S514/858 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/951

Abstract: The treatment of ungual and subungual diseases is disclosed, wherein the treatment comprises the local injection of a colution containing a metallic material with atomic disorder under the nail or into the nail bed and/or the surrounding tisuue.

Abstract translation: 本发明公开了治疗不良和亚疾病的方法，其中所述治疗包括局部注射包含在钉子下方的原子紊乱的金属材料或进入甲床和/或周围的织物的溶出物。

公开(公告)号：WO2002085299A2

公开(公告)日：2002-10-31

申请号：PCT/US2002/012690

申请日：2002-04-23

Applicant: NUCRYST PHARMACEUTICALS CORP.

Inventor： BURRELL, Robert, E. ,  GILLIS, Scott, H.

IPC: A61K

CPC classification number: A61K9/0024 ,  A01N59/16 ,  A61K9/0019 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/14 ,  A61K9/7007 ,  A61K33/24 ,  A61K33/38 ,  A61K33/40 ,  A61K47/34 ,  A61K47/38 ,  A61L15/46 ,  A61L17/145 ,  A61L27/30 ,  A61L29/10 ,  A61L31/082 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/452 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2300/63 ,  Y10S424/15 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/829 ,  Y10S514/83 ,  Y10S514/849 ,  Y10S514/851 ,  Y10S514/853 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/864 ,  Y10S514/865 ,  Y10S514/88 ,  Y10S514/881 ,  Y10S514/882 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902 ,  Y10S514/912 ,  Y10S514/914 ,  Y10S514/925 ,  Y10S514/931 ,  Y10S514/932 ,  Y10S514/933 ,  Y10S514/934 ,  Y10S514/944 ,  Y10S514/951 ,  Y10S514/953 ,  Y10S514/954 ,  Y10S514/956 ,  Y10S514/958 ,  Y10S514/964 ,  Y10S514/965 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968 ,  Y10S514/969 ,  Y10T428/31855 ,  A61K2300/00 ,  A01N25/04 ,  A01N25/10 ,  A01N25/12

Abstract: Therapeutic treatments using the direct application of selected structures of antimicrobial metals in free-standing powder form, solution form and/or suspension form in therapeutically effective amounts. The selected structures of antimicrobial metals serve as an antimicrobial agent, an anti-inflammatory agent, an immuno modulator agent, an enzyme modulator agent, and/or an anti-tumor agent, for human and/or animal use.

Abstract translation: 使用以治疗有效量直接施用选择的抗微生物金属结构的自由粉末形式，溶液形式和/或悬浮液形式的治疗性治疗。 抗微生物金属的所选结构用作人和/或动物使用的抗微生物剂，抗炎剂，免疫调节剂，酶调节剂和/或抗肿瘤剂。

公开(公告)号：WO2006105362A2

公开(公告)日：2006-10-05

申请号：PCT/US2006/011821

申请日：2006-03-29

Applicant: NUCRYST PHARMACEUTICALS CORP. ,  GILLIS, Scott H.

Inventor： GILLIS, Scott H.

IPC: A61L15/18 ,  A61L15/16 ,  A61L27/04

CPC classification number: A61L15/18 ,  A61K33/24 ,  A61K33/38 ,  A61K35/12 ,  A61K45/06 ,  A61L15/46 ,  A61L24/0015 ,  A61L24/02 ,  A61L27/04 ,  A61L27/54 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  A61K2300/00

Abstract: Biocompatible articles and related methods are disclosed.

Abstract translation: 公开了生物相容性制品及相关方法。