公开(公告)号：JP2003328161A

公开(公告)日：2003-11-19

申请号：JP2003139417

申请日：2003-05-16

Applicant: Nawotec Gmbh ,  Univ Of Maryland Office Of Technology Commercialization ,  ナヴォテック・ゲーエムベーハー ,  ユニバーシティ・オブ・メリーランド・オフィス・オブ・テクノロジー・コマーシャリゼーション

Inventor： KOOPS HANS WILFRIED PETER ,  EDINGER KLAUS

IPC: C23F4/00 ,  G03F1/00 ,  H01J37/305 ,  H01L21/302 ,  H01L21/311

CPC classification number: H01L21/31122 ,  G03F1/74 ,  H01J37/3056 ,  H01J2237/3174 ,  H01J2237/31744 ,  H01L21/31105

Abstract: PROBLEM TO BE SOLVED: To provide a method for etching material at its surface by a focused electronic beam for deriving a chemical reaction on the surface. SOLUTION: The method comprises irradiating the material to be etched by using at least one molecular beam, at least one photon beam and at least one electronic beam in a vacuum atmosphere, exciting the irradiated material and the molecules of the molecular beam so as to induce the prescribed chemical reaction by the compositions of the material and the molecules and to form a reaction product, and removing the reaction product from the surface of the material, i.e., having irradiating and removing steps. COPYRIGHT: (C)2004,JPO

Abstract translation: 要解决的问题：提供一种通过聚焦电子束在其表面上蚀刻材料以在表面上引起化学反应的方法。 解决方案：该方法包括通过使用至少一个分子束，至少一个光子束和至少一个电子束在真空气氛中照射待蚀刻的材料，激发被照射的材料和分子束的分子，从而 通过该材料和分子的组合物诱导规定的化学反应并形成反应产物，并从该材料表面除去反应产物，即具有照射和去除步骤。 版权所有（C）2004，JPO

公开(公告)号：WO2020061346A1

公开(公告)日：2020-03-26

申请号：PCT/US2019/051979

申请日：2019-09-19

Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARK OFFICE OF TECHNOLOGY COMMERCIALIZATION

Inventor： ZHU, Qiang ,  CHEN, Mingliang ,  WU, Min ,  WONG, Chau-Wai

IPC: G06N3/02 ,  G06N3/08 ,  G10L15/20 ,  G10L25/30

Abstract: Systems, methods, apparatuses, and computer program products for tracking weak signal traces under severe noise and/or distortions. A method may include tracking at least one candidate frequency trace from a time-frequency representation of a signal. The method may also include identifying a frequency trace of the signal based on tracking results. In addition, the method may include outputting an estimated frequency vector related to the frequency trace. Further, the tracking may be performed under a noisy condition environment.

公开(公告)号：WO2007109228A1

公开(公告)日：2007-09-27

申请号：PCT/US2007/006809

申请日：2007-03-19

Applicant: NATIONAL INSTITUTES OF HEALTH ,  UNIVERSITY OF MARYLAND OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  GOMEZ, Romel, Del Rosario ,  KHAN, Javed ,  PANDANA, Herman ,  ASCHENBACH, Konrad ,  FUHRER, Michael ,  WEI, Jun

Inventor： GOMEZ, Romel, Del Rosario ,  KHAN, Javed ,  PANDANA, Herman ,  ASCHENBACH, Konrad ,  FUHRER, Michael ,  WEI, Jun

IPC: C12Q1/68

CPC classification number: G01N33/5438 ,  B82Y15/00 ,  B82Y30/00 ,  Y10S977/702 ,  Y10S977/92 ,  Y10S977/938

Abstract: A microarray apparatus is provided which contains at least one chip having source and drain electrodes positioned on an array of carbon nanotube transistors which allows for electronic detection of nucleic acid hybridizations, thereby affording both increased sensitivity and the capability of miniaturization.

Abstract translation: 提供一种微阵列装置，其包含至少一个芯片，其具有位于碳纳米管晶体管阵列上的源极和漏极，其允许电子检测核酸杂交，从而提供增加的灵敏度和小型化的能力。

公开(公告)号：WO2016168444A1

公开(公告)日：2016-10-20

申请号：PCT/US2016/027501

申请日：2016-04-14

Applicant: PURDUE RESEARCH FOUNDATION OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  TURRINI, Francesco ,  PANTALEO, Antonella

Inventor： TURRINI, Francesco ,  PANTALEO, Antonella ,  LOW, Philip S.

IPC: A61K31/505 ,  A61K31/506 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12

CPC classification number: A61K31/506 ,  A61K31/505

Abstract: The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds that inhibit the spleen tyrosine kinse (SYK). In some embodiments a method is presented to prevent thrombosis in blood vessels of patients with a hemolytic disease comprising the step of: administrating to a patient having at least one hemolytic disease a therapeutically effective amount of at least one SYK inhibitor. In some embodiments the method includes repeatedly administering the SYK kinase inhibitor to a patient.

Abstract translation: 本公开总体上涉及使用激酶抑制剂治疗溶血性疾病如镰状细胞性贫血的方法，例如抑制脾脏酪氨酸激酶（SYK）的化合物。 在一些实施方案中，提出了一种用于预防患有溶血性疾病的患者的血管中的血栓形成的方法，包括以下步骤：向具有至少一种溶血性疾病的患者施用治疗有效量的至少一种SYK抑制剂。 在一些实施方案中，该方法包括向患者重复施用SYK激酶抑制剂。

公开(公告)号：WO2014062985A1

公开(公告)日：2014-04-24

申请号：PCT/US2013/065548

申请日：2013-10-17

Applicant: UNIVERSITY OF MARYLAND, OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  CHILDREN'S NATIONAL MEDICAL CENTER ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH

Inventor： AYYUB, Omar Bilal ,  BEHRENS, Adam Michael ,  KOFINAS, Peter ,  SUMMAR, Marshall Lynn ,  CABRERA-LUQUE, Juan Manuel ,  CUNNINGHAM, Gary ,  SIMEONOV, Anton ,  MARUGAN, Juan

IPC: G01N17/04 ,  G01F1/64 ,  C12N9/00 ,  C12N11/00

CPC classification number: C12Q1/005 ,  C12N9/0018 ,  C12N9/0071 ,  C12N11/04 ,  C12N11/10 ,  G01N27/3277 ,  G01N33/6812 ,  G01N2800/04 ,  G01N2800/52

Abstract: The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the hydrogel.

Abstract translation: 本发明涉及能够使用包含由水凝胶改性的电极的无试剂系统来测量一种或多种氨基酸的总浓度的生物传感器，该电极包含至少一种氧化至少一种至少一种至少一种底物的酶 一个氨基酸。 在一些实施方案中，生物传感器包含包含藻酸盐的水凝胶。 在一些实施方案中，生物传感器包括使用固定或附着在水凝胶上的嗜热细菌代谢酶。

公开(公告)号：WO2007084700A3

公开(公告)日：2007-07-26

申请号：PCT/US2007/001501

申请日：2007-01-19

Applicant: UNIVERSITY OF MARYLAND OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  WEN, Xingzhi ,  VISHKIN, Uzi, Yehoshua

Inventor： WEN, Xingzhi ,  VISHKIN, Uzi, Yehoshua

IPC: G06F9/48

Abstract: An Explicit Multi-Threading (XMT) system and method is provided for processing multiple spawned threads associated with SPAWN-type commands of an XMT program. The method includes executing a plurality of child threads by a plurality of TCUs including a first TCU executing a child thread which is allocated to it; completing execution of the child thread by the first TCU; announcing that the first TCU is available to execute another child thread; executing by a second TCU a parent child thread that includes a nested spawn-type command for spawning additional child threads of the plurality of child threads, wherein the parent child thread is related in a parent-child relationship to the child threads that are spawned in conjunction with the nested spawn-type command; assigning a thread ID (TID) to each child thread, wherein the TID is unique with respect to the other TIDs; and allocating a new child thread to the first TCU.

公开(公告)号：WO2019018371A1

公开(公告)日：2019-01-24

申请号：PCT/US2018/042451

申请日：2018-07-17

Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  DUKE UNIVERSITY

Inventor： FRANK, Barnett, Samuel ,  PADUA, Darin, Anthony ,  MAZZOLENI, Michael, Joseph ,  MANN, Brian, Patrick

IPC: A61B5/11 ,  A61B5/00 ,  A61B5/024 ,  A61B5/1455

Abstract: A system for assessing lower extremity movement quality includes one or more user sensors, at least one processor, and a movement evaluator implemented using the at least one processor. The movement evaluator is configured, by virtue of appropriate programming, for receiving movement data from the one or more user sensors during a user's performance of a movement task; extracting one or more movement features from the movement data, each movement feature characterizing a respective aspect of a movement pattern of the user's performance that is associated with lower extremity injury risk; and classifying the movement pattern into a classified risk category for lower extremity injury for the user based on the one or more movement features.

公开(公告)号：WO2016172365A1

公开(公告)日：2016-10-27

申请号：PCT/US2016/028686

申请日：2016-04-21

Applicant: PURDUE RESEARCH FOUNDATION OFFICE OF TECHNOLOGY COMMERCIALIZATION

Inventor： RICKUS, Jenna Leigh ,  HARBIN, Sherry L. ,  KAHN, Jennifer L.

IPC: C12N11/04 ,  C12N11/14

CPC classification number: C07K14/78 ,  C12N5/0012 ,  C12N5/0697 ,  C12N11/04 ,  C12N11/14

Abstract: Soluble, self-assembling collagens derived from tissues are extensively characterized such that one can predict and customize the final collagen-fibril matrix with respect to fibril microstructure (i.e.,fibril density, interfibril branching), viscoelasticity, and proteolytic degradability. As shown herein these matrices template and direct the deposition of mesoporous silica at the level of individual collagen fibrils. The fibril density, silicic acid concentration, and time of exposure to silicifying solution were varied and the resulting hybrid materials were analyzed by scanning electron microscopy, energy-dispersive x-ray spectroscopy, and rheology. Microstructural properties of the collagen-fibril template are preserved in the silica surface of hybrid materials. Results for three different collagen fibril densities, corresponding to shear storage moduli of 200 Pa, 1000 Pa, and 1600 Pa, indicate that increased fibril density increases the absolute amount of templated silica when all other silica synthesis conditions are kept constant. The mechanical properties of the hybrid material are dominated by the presence of the silica coating rather than the starting collagen matrix stiffness.

Abstract translation: 衍生自组织的可溶性自组装胶原蛋白被广泛地表征，使得人们可以相对于原纤维微结构（即原纤维密度，纤丝分支），粘弹性和蛋白水解降解性来预测和定制最终的胶原纤维基质。 如本文所示，这些基质模拟并引导介孔二氧化硅在单个胶原原纤维水平的沉积。 改变原纤维密度，硅酸浓度和暴露于硅化溶液的时间，通过扫描电子显微镜，能量色散X射线光谱和流变学分析所得的杂化材料。 胶原纤维模板的微观结构性质保留在混合材料的二氧化硅表面。 对应于200 Pa，1000 Pa和1600 Pa的剪切储存模量的三种不同胶原纤维密度的结果表明，当所有其他二氧化硅合成条件保持恒定时，增加的原纤维密度增加模板二氧化硅的绝对量。 杂化材料的机械性能由二氧化硅涂层的存在主导，而不是起始胶原基质刚度。

公开(公告)号：WO2021113807A1

公开(公告)日：2021-06-10

申请号：PCT/US2020/063588

申请日：2020-12-07

Applicant: THE UNIVERSITY OF NORTH CAROLINA ATCHAPEL HILL OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  MIZAR IMAGING, LLC

Inventor： MADDOX, Paul, Samuel ,  SMITH, Joel, Carter

IPC: G01N1/18 ,  G01N1/36 ,  G01N1/20 ,  B01L3/50 ,  G01N1/2813

Abstract: Devices, systems, and methods for imaging samples. In some examples, a device includes at least two basins for holding a liquid medium, the at least two basins including a sample chamber and a reservoir. The device includes a wedge between the sample chamber and the reservoir, and the wedge protrudes into the sample chamber and defines a space between the wedge and a bottom of the sample chamber. The space is sized for holding one or more biological samples. The device is formed to define a flow channel between the sample chamber and the reservoir, and the flow channel is shaped to allow the passage of the liquid medium from the sample chamber and the reservoir and to block passage of the one or more biological samples between the sample chamber and the reservoir.

公开(公告)号：WO2018022165A9

公开(公告)日：2018-02-01

申请号：PCT/US2017/030906

申请日：2017-05-03

Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARK OFFICE OF TECHNOLOGY COMMERCIALIZATION

Inventor： BARAS, John S. ,  WENG, Xiangnan

IPC: G06Q30/00

Abstract: Various communication systems may benefit from optimized delivery or dissemination of information. For example, various wireless networks including heterogeneous wireless may benefit from joint optimization for social content delivery or dissemination over such networks. A method can include selecting content to deliver according to user reward values given wireless capacity constraints. The method can also include delivering the content to a plurality of users via a wireless network comprising different transmission modes.