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公开(公告)号：WO2009071691A2
公开(公告)日：2009-06-11
申请号：PCT/EP2008/066937
申请日：2008-12-05
Applicant: ABBOTT GMBH & CO. KG , NETZ, Astrid , OOST, Thorsten , GENESTE, Hervé , BRAJE, Wilfried , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
Inventor： NETZ, Astrid , OOST, Thorsten , GENESTE, Hervé , BRAJE, Wilfried , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
CPC classification number: C07D401/14 , C07D401/04 , C07D401/12 , C07D487/04 , C07D487/08
Abstract: Die vorliegende Erfindung betrifft neue substituierte Oxindol-Derivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung zur Behandlung von Vasopressin-abhängigen Erkrankungen.
Abstract translation: 本发明涉及新的取代的羟吲哚衍生物，含有它们以及它们用于加压素依赖性疾病的治疗中使用的药物组合物。
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2.发明申请SUBSTITUTED OXINDOLE DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF 审中-公开取代的氧杂吲哚衍生物，含有它们的药物及其用途
公开(公告)号：WO2006072458A3
公开(公告)日：2006-10-05
申请号：PCT/EP2005014150
申请日：2005-12-30
Applicant: ABBOTT GMBH & CO KG , LUBISCH WILFRIED , OOST THORSTEN , WERNET WOLFGANG , UNGER LILIANE , HORNBERGER WILFRIED , GENESTE HERVE
Inventor： LUBISCH WILFRIED , OOST THORSTEN , WERNET WOLFGANG , UNGER LILIANE , HORNBERGER WILFRIED , GENESTE HERVE
IPC: C07D401/12 , A61K31/496 , A61P25/00 , C07D403/12 , C07D417/12
CPC classification number: C07D209/40 , C07D401/04 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention relates to novel oxindole derivatives of general formula (I), wherein substituents A, B, X and Y are defined as in Claim I, medicaments containing said derivatives, and the use thereof in the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.
Abstract translation: 本发明涉及其中取代基A，B，X和Y如权利要求1中定义的通式（I）的新的羟吲哚衍生物，含有它们以及它们用于加压素依赖性和/或预防和/或治疗的药物组合物 催产素依赖性疾病。
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公开(公告)号：WO2012130633A1
公开(公告)日：2012-10-04
申请号：PCT/EP2012/054616
申请日：2012-03-15
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , MARTYRES, Domnic , ANDERSKEWITZ, Ralf , HOENKE, Christoph , KRIEGL, Jan , OOST, Thorsten , RIST, Wolfgang , SEITHER, Peter
Inventor： MARTYRES, Domnic , ANDERSKEWITZ, Ralf , HOENKE, Christoph , KRIEGL, Jan , OOST, Thorsten , RIST, Wolfgang , SEITHER, Peter
IPC: C07D403/10 , A61P29/00 , A61K31/4155
CPC classification number: C07D403/10 , A61K31/335 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4184 , A61K31/421 , A61K31/437 , A61K31/52 , A61K45/06 , C07D471/04 , C07D473/00 , C07D487/04
Abstract: The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2 antagonistic activity, wherein L, Y 1 , Y 2 , Y 3 , Y 4 , Y 5 , Z, R 1 , R 2 , R 3 and n have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical compositions containing said compounds and to pharmaceutical compositions containing said compounds in combination with one or more active substances.
Abstract translation: 本发明涉及具有CRTH2拮抗活性的式（I）的吡唑化合物及其药学上可接受的盐，其中L，Y1，Y2，Y3，Y4，Y5，Z，R1，R2，R3和n具有以下含义之一： 在说明书和权利要求书中指出其作为药物的用途，含有所述化合物的药物组合物和含有所述化合物与一种或多种活性物质组合的药物组合物。
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公开(公告)号：WO2009103478A1
公开(公告)日：2009-08-27
申请号：PCT/EP2009/001081
申请日：2009-02-17
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , STENKAMP, Dirk , BUDZINSKI, Ralph-Michael , HECKEL, Armin , KLEY, Joerg , LEHMANN-LINTZ, Thorsten , MUELLER, Stephan, Georg , OOST, Thorsten , ROTH, Gerald, Juergen , RUDOLF, Klaus , SCHINDLER, Marcus , LOTZ, Ralf , THOMAS, Leo
Inventor： STENKAMP, Dirk , BUDZINSKI, Ralph-Michael , HECKEL, Armin , KLEY, Joerg , LEHMANN-LINTZ, Thorsten , MUELLER, Stephan, Georg , OOST, Thorsten , ROTH, Gerald, Juergen , RUDOLF, Klaus , SCHINDLER, Marcus , LOTZ, Ralf , THOMAS, Leo
IPC: C07D213/64 , C07D213/69 , C07D237/14 , C07D237/16 , C07D401/10 , C07D401/14 , C07D401/12 , C07D471/04 , A61K31/435 , A61K31/47 , A61K31/495
CPC classification number: C07D401/10 , C07D213/64 , C07D213/69 , C07D237/14 , C07D237/16 , C07D401/12 , C07D401/14 , C07D471/04
Abstract: The present invention relates to pyridone and pyridazinone derivatives as listed in claim 1 including their salts. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH- receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
Abstract translation: 本发明涉及权利要求1所述的吡啶酮和哒嗪酮衍生物，包括它们的盐。 此外，本发明涉及含有至少一种本发明化合物的药物组合物。 由于其MCH-受体拮抗活性，根据本发明的药物组合物适用于治疗代谢紊乱和/或进食障碍，特别是肥胖，贪食症，厌食症，食欲过盛和糖尿病。
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5.发明申请5,6-DISUBSTITUTED OXINDOLE-DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSINE-DEPENDENT DISEASES 审中-公开5,6-二取代的羟吲哚衍生物及其使用抗利尿激素依赖性疾病的治疗
公开(公告)号：WO2009071690A3
公开(公告)日：2009-07-23
申请号：PCT/EP2008066935
申请日：2008-12-05
Applicant: ABBOTT GMBH & CO KG , BRAJE WILFRIED , OOST THORSTEN , NETZ ASTRID , WERNET WOLFGANG , UNGER LILIANE , HORNBERGER WILFRIED , LUBISCH WILFRIED
Inventor： BRAJE WILFRIED , OOST THORSTEN , NETZ ASTRID , WERNET WOLFGANG , UNGER LILIANE , HORNBERGER WILFRIED , LUBISCH WILFRIED
IPC: C07D401/14 , A61K31/4545 , A61K31/496 , A61P3/10 , A61P7/02 , A61P9/00 , A61P25/00
CPC classification number: C07D401/14
Abstract: The invention relates to novel 5,6-disubstituted oxindole derivatives, to pharmaceutical agents containing said components and to the use thereof for producing a medicament.
Abstract translation: 本发明涉及新的5,6-二取代的羟吲哚衍生物，含有它们和它们用于制备药物的制造中使用的药物组合物。 其中R1和R2独立地为氢，C1-C3烷基，C1-C3氟烷基，C1-C3烷氧基，C1-C3氟烷氧基，卤素或CN; R3是氢或C1-C4烷基; R4是乙氧基，氟化乙氧基或异丙基; R5是氢或甲基; R6是Br，Cl，F或CN; R 7是Cl，F或CN; R8和R9独立地是C1-C3烷基或C1-C3氟烷基; X 1是O，NH或CH 2; X2和X3是N或CH，条件是X 2和X 3不同时为N; X 4是N或CH; a和b独立地为0，1或2; 且m，n，p为0并且独立地为1,2或3;
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Patent Agency Ranking6.发明申请5-HALOGEN-SUBSTITUIERTE OXINDOL-DERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON VASOPRESSIN-ABHÄNGIGEN ERKRANKUNGEN 审中-公开5个卤素取代的羟吲哚衍生物及其使用加压素依赖性疾病治疗
公开(公告)号：WO2009071689A2
公开(公告)日：2009-06-11
申请号：PCT/EP2008/066934
申请日：2008-12-05
Applicant: ABBOTT GMBH & CO. KG , BRAJE, Wilfried , OOST, Thorsten , NETZ, Astrid , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
Inventor： BRAJE, Wilfried , OOST, Thorsten , NETZ, Astrid , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
IPC: C07D401/14 , A61K31/496 , A61K31/4545 , A61P3/10 , A61P7/02 , A61P9/00 , A61P25/00
CPC classification number: C07D401/14
Abstract: Die vorliegende Erfindung betrifft neue 5-Halogen-substituierte Oxindol-Derivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung zur Behandlung von Vasopressin-abhängigen Erkrankungen.
Abstract translation: 本发明涉及新的5-卤代 - 取代的羟吲哚衍生物，含有它们以及它们用于加压素依赖性疾病的治疗中使用的药物组合物。
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7.发明申请AMIDOMETHYL-SUBSTITUIERTE OXINDOL-DERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON VASOPRESSIN-ABHÄNGIGEN ERKRANKUNGEN 审中-公开酰氨基甲基吲哚的取代的衍生物及其使用抗利尿激素依赖性疾病的治疗
公开(公告)号：WO2009071687A1
公开(公告)日：2009-06-11
申请号：PCT/EP2008/066931
申请日：2008-12-05
Applicant: ABBOTT GMBH & CO. KG , OOST, Thorsten , NETZ, Astrid , GENESTE, Hervé , BRAJE, Wilfried , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
Inventor： OOST, Thorsten , NETZ, Astrid , GENESTE, Hervé , BRAJE, Wilfried , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
IPC: C07D401/14 , A61K31/496 , A61P3/00 , A61P7/00 , A61P9/00 , A61P25/00
CPC classification number: C07D401/14
Abstract: Die vorliegende Erfindung betrifft neue Amidomethyl-substituierte Oxindol-Derivate der Formel (I), diese enthaltende pharmazeutische Mittel und ihre Verwendung zur Behandlung von Vasopressin-abhängigen Erkrankungen, worin R 1 für Wasserstoff, Methoxy oder Ethoxy steht; R 2 für Wasserstoff oder Methoxy steht; R 3 für Wasserstoff, Methyl, Ethyl, n-Propyl oder Isopropyl steht; X 1 und X 2 für N oder CH stehen, unter der Maßgabe, dass X 1 und X 2 nicht gleichzeitig für N stehen.
Abstract translation: 本发明涉及式（I）的新颖的酰氨基甲基取代的羟吲哚衍生物，含有它们和它们用于治疗加压素依赖性疾病的方法，其中R1是氢，甲氧基或乙氧基的药物组合物; R 2是氢或甲氧基; R3是氢，甲基，乙基，正丙基或异丙基; X1和X2是N或CH，条件是X1和X2不同时为N.条件
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8.发明申请SUBSTITUTED OXINDOLE DERIVATIVES AND THEIR USE AS VASOPRESSIN RECEPTOR LIGANDS 审中-公开取代的氧化衍生物及其作为血管收缩素受体配体使用
公开(公告)号：WO2008080973A1
公开(公告)日：2008-07-10
申请号：PCT/EP2007/064622
申请日：2007-12-28
Applicant: ABBOTT GMBH & CO. KG , NETZ, Astrid , OOST, Thorsten , GENESTE, Hervé , BRAJE, Wilfried Martin , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
Inventor： NETZ, Astrid , OOST, Thorsten , GENESTE, Hervé , BRAJE, Wilfried Martin , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
IPC: C07D401/14 , A61K31/444 , A61P25/00 , A61P7/00 , A61P9/00
CPC classification number: A61K31/506 , A61K31/4545 , C07D401/14
Abstract: The present invention relates to novel oxindole derivatives of the general formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dependent.
Abstract translation: 本发明涉及通式（I）的新型羟基吲哚衍生物与包含它们的药物及其用于预防和/或治疗依赖于加压素的疾病的用途。
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公开(公告)号：WO2011092140A1
公开(公告)日：2011-08-04
申请号：PCT/EP2011/050910
申请日：2011-01-24
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , OOST, Thorsten , ANDERSKEWITZ, Ralf , HAMPRECHT, Dieter, Wolfgang , HOENKE, Christoph , MARTYRES, Domnic , RIST, Wolfgang , SEITHER, Peter
Inventor： OOST, Thorsten , ANDERSKEWITZ, Ralf , HAMPRECHT, Dieter, Wolfgang , HOENKE, Christoph , MARTYRES, Domnic , RIST, Wolfgang , SEITHER, Peter
IPC: C07D231/12 , A61K31/415 , A61P29/00 , A61P37/00
CPC classification number: C07D231/12 , C07D401/06 , C07D405/12
Abstract: The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2-activity, wherein W, L 1 , L 2 , X, L 3 , Y, R 1 and R 2 are as defined in the specification and claims, to their use as medicaments and to pharmaceutical formulations, containing said compounds or containing a combination of said compounds with one or more active substances.
Abstract translation: 本发明涉及具有CRTH2-活性的式（I）的吡唑化合物及其药学上可接受的盐，其中W，L1，L2，X，L3，Y，R1和R2如说明书和权利要求中所定义， 作为药物和药物制剂，含有所述化合物或含有所述化合物与一种或多种活性物质的组合。
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10.发明申请SUBSTITUIERTE OXINDOL-DERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON VASOPRESSIN-ABHÄNGIGEN ERKRANKUNGEN 审中-公开取代羟吲哚衍生物及其使用抗利尿激素依赖性疾病的治疗
公开(公告)号：WO2009083559A1
公开(公告)日：2009-07-09
申请号：PCT/EP2008/068254
申请日：2008-12-23
Applicant: ABBOTT GMBH & CO. KG , BRAJE, Wilfried , NETZ, Astrid , OOST, Thorsten , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
Inventor： BRAJE, Wilfried , NETZ, Astrid , OOST, Thorsten , WERNET, Wolfgang , UNGER, Liliane , HORNBERGER, Wilfried , LUBISCH, Wilfried
IPC: C07D401/14 , A61K31/4439 , A61K31/496 , A61P25/00
CPC classification number: C07D401/14 , C07D209/34 , C07D401/04
Abstract: Die vorliegende Erfindung betrifft neue substituierte Oxindol-Derivate der Formel (I), diese enthaltende pharmazeutische Mittel und ihre Verwendung zur Behandlung von Vasopressin-abhängigen Erkrankungen.
Abstract translation: 本发明涉及式（I）下式的新的羟吲哚取代的衍生物，含有它们以及它们用于加压素依赖性疾病的治疗中使用的药物组合物。
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