BIOADHESIVE COMPOSITION AND DEVICE FOR REPAIRING TISSUE DAMAGE
    4.
    发明申请
    BIOADHESIVE COMPOSITION AND DEVICE FOR REPAIRING TISSUE DAMAGE 审中-公开
    用于修复组织损伤的生物粘合剂组合物和装置

    公开(公告)号:WO2012042522A3

    公开(公告)日:2012-07-19

    申请号:PCT/IL2011000765

    申请日:2011-09-27

    CPC classification number: A61K31/79 A61K31/765 A61L24/046 C08L67/04

    Abstract: The present disclosure provides a bioadhesive composition and device comprising same, the composition comprising a polymeric matrix and at least one synthetic bioadhesive polymer carried by the polymeric matrix, the polymeric matrix comprising at least one synthetic thermoplastic polymer characterized by one or more of (a) an average molecular weight in the range of between 20,000Da to 90,000Da; and (b) it comprises polycaprolactone (PCL); wherein exposure to heat causes the bioadhesive composition to transform into a non-solid state and to cohesively adhere to a biological tissue upon subsequent cooling thereof. Also provided herein are methods of preparing the composition or device, and use of the composition or device in therapy, e.g. for treating hernia.

    Abstract translation: 本公开内容提供了一种生物粘附组合物和包含它的装置,所述组合物包含聚合物基质和由所述聚合物基质携带的至少一种合成生物粘附聚合物,所述聚合物基质包含至少一种合成热塑性聚合物,其特征在于以下一种或多种:(a) 平均分子量为20,000Da至90,000Da; 和(b)它包含聚己酸内酯(PCL); 其中暴露于热引起生物粘合剂组合物转变成非固体状态并且随后在其冷却后粘附到生物组织上。 本文还提供了制备组合物或装置的方法以及组合物或装置在治疗中的用途,例如, 用于治疗疝气。

    BIOADHESIVE COMPOSITION AND DEVICE FOR REPAIRING TISSUE DAMAGE
    5.
    发明申请
    BIOADHESIVE COMPOSITION AND DEVICE FOR REPAIRING TISSUE DAMAGE 审中-公开
    生物组合物和修复组织损伤的装置

    公开(公告)号:WO2012042522A2

    公开(公告)日:2012-04-05

    申请号:PCT/IL2011/000765

    申请日:2011-09-27

    CPC classification number: A61K31/79 A61K31/765 A61L24/046 C08L67/04

    Abstract: The present disclosure provides a bioadhesive composition and device comprising same, the composition comprising a polymeric matrix and at least one synthetic bioadhesive polymer carried by the polymeric matrix, the polymeric matrix comprising at least one synthetic thermoplastic polymer characterized by one or more of (a) an average molecular weight in the range of between 20,000Da to 90,000Da; and (b) it comprises polycaprolactone (PCL); wherein exposure to heat causes the bioadhesive composition to transform into a non-solid state and to cohesively adhere to a biological tissue upon subsequent cooling thereof. Also provided herein are methods of preparing the composition or device, and use of the composition or device in therapy, e.g. for treating hernia.

    Abstract translation: 本公开内容提供了包含其的生物粘附剂组合物和装置,所述组合物包含聚合物基质和由聚合物基质携带的至少一种合成生物粘附聚合物,所述聚合物基质包含至少一种合成热塑性聚合物,其特征在于以下一种或多种(a) 在20,000Da至90,000Da范围内的平均分子量; 和(b)它包括聚己酸内酯(PCL); 其中暴露于热使得生物粘附性组合物转变成非固体状态并且随后在其冷却时粘附到生物组织。 本文还提供了制备组合物或装置的方法,以及组合物或装置在治疗中的用途,例如, 用于治疗疝气。

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