公开(公告)号：ES2397356T3

公开(公告)日：2013-03-06

申请号：ES06790906

申请日：2006-10-31

Applicant: OTI OPHTHALMIC TECHNOLOGIES INC ,  OPTOS PLC

Inventor： ROGERS JOHN ,  HATHAWAY MARK

IPC: A61B3/12 ,  A61B3/10 ,  G01N21/47

Abstract: Un procedimiento para realizar formación de imágenes por tomografía de coherencia óptica espectral sobre unadiana (14), que comprende: explorar repetidamente dicha diana a lo largo de una única línea de exploración transversal con un haz delobjeto derivado de un interferómetro de tomografía de coherencia óptica que tiene una fuente de bandaestrecha (10); barrer la longitud de onda de dicha fuente de banda estrecha sobre un intervalo de longitudes de onda a unavelocidad que es lenta con respecto a la velocidad de exploración de dicha diana, de modo que cada línea deexploración se realiza a una frecuencia o intervalo estrecho de frecuencias particular en el intervalo delongitudes de onda; detectar el haz del objeto (21, 22) devuelto desde la diana para producir un conjunto de datos obtenidos demúltiples exploraciones a lo largo de dicha línea de exploración sobre dicho intervalo de longitudes de onda; yprocesar dicho conjunto de datos para extraer una imagen de sección de tomografía de coherencia ópticalongitudinal de dicha diana (14) que contiene información de profundidad.

公开(公告)号：WO2004002298A1

公开(公告)日：2004-01-08

申请号：PCT/CA2003/000993

申请日：2003-06-27

Applicant: OTI OPHTHALMIC TECHNOLOGIES INC. ,  PODOLEANU, Adrian, Gh. ,  JACKSON, David, A. ,  ROGERS, John, A. ,  DOBRE, George, M. ,  CUCU, Radu, G.

Inventor： PODOLEANU, Adrian, Gh. ,  JACKSON, David, A. ,  ROGERS, John, A. ,  DOBRE, George, M. ,  CUCU, Radu, G.

IPC: A61B3/12

CPC classification number: A61B3/102 ,  A61B3/1025 ,  G01N21/4795

Abstract: The present invention relates to a multiple channel optical mapping apparatus which can deliver one or simultaneously at least two images of different depth resolutions or sequentially, images with different depth resolutions, or a combination of these images, or a single image with adjustable depth resolution. The multiple channels could be either multiple confocal channel and one or two optical coherence tomography channel, or two optical coherence tomogrraphy channels, or two confocal channels. The channels, either OCT or confocal can operate on the same wavelength or on different wavelengths. The apparatus can display both transversal as well as longitudinal images in an object, particularly the eye.

Abstract translation: 本发明涉及一种多通道光学映射设备，其可以递送不同深度分辨率的一个或同时至少两个图像或顺序地，具有不同深度分辨率的图像，或这些图像的组合，或者具有可调节的深度分辨率的单个图像。 多个通道可以是多个共焦通道和一个或两个光学相干断层扫描通道，或两个光学相干断层图像通道或两个共聚焦通道。 OCT或共焦的通道可以在相同波长或不同波长下工作。 该装置可以在物体，特别是眼睛中显示横向和纵向图像。

公开(公告)号：WO2003086181A1

公开(公告)日：2003-10-23

申请号：PCT/CA2003/000529

申请日：2003-04-08

Applicant: OTI-OPHTHALMIC TECHNOLOGIES INC.

Inventor： PODOLEANU, Adrian ,  ROGERS, John

IPC: A61B3/12

CPC classification number: A61B3/102 ,  A61B3/1025 ,  G01B9/0203 ,  G01B9/02077 ,  G01B9/02083 ,  G01B9/02091 ,  G01B2290/65

Abstract: Apparatus for high resolution imaging of a moving object comprises a source of low coherence light, an optical coherence tomography imaging instrument or a dual channel, optical coherence tomography/confocal imaging instrument, a transverse scanner, an interferometer, depth adjustment means, and interface optics. First and an optional second sensing blocks sense the axial and respectively the transverse position of the object. A splitting element is shared so that the interface optics and the sensing blocks have a common axis of light transmitted to and from the object. Timing means establishes a timing, and timing intervals and reference times for images as they are taken. The acceptability of each scanned image is determined according to predetermined criteria. A series of en-face OCT images, or of longitudinal OCT images of the object may be taken at different depths or transverse coordinates, and the stack of collected images is used to build 3D profiles of the object.

Abstract translation: 用于运动物体的高分辨率成像的装置包括低相干光源，光学相干断层摄影成像仪器或双通道光学相干断层摄影/共焦成像仪器，横向扫描仪，干涉仪，深度调节装置和界面光学器件 。 首先和可选的第二感测块感测物体的轴向和横向位置。 分离元件被共享，使得界面光学元件和感测块具有传输到物体的物体的共同的光轴。 定时手段为图像建立定时，定时间隔和参考时间。 每个扫描图像的可接受性根据预定标准确定。 可以在不同的深度或横向坐标处拍摄一系列面孔OCT图像或对象的纵向OCT图像，并且使用所收集的图像的堆叠来构建对象的3D轮廓。

公开(公告)号：WO2008000078A1

公开(公告)日：2008-01-03

申请号：PCT/CA2007/001148

申请日：2007-06-28

Applicant: OTI OPHTHALMIC TECHNOLOGIES INC. ,  PODOLEANU, Adrian G.H.

Inventor： PODOLEANU, Adrian G.H.

IPC: A61B3/10 ,  A61B3/117 ,  G01B11/24 ,  G01N21/958

CPC classification number: G01N21/4795 ,  A61B3/102 ,  G01B9/0203 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/70

Abstract: An optical coherence tomography (OCT) apparatus includes an optical source, an interferometer generating an object beam and a reference beam, a transverse scanner for scanning an object with said object beam, and a processor for generating an OCT image from an OCT signal returned by said interferometer. At least the optical source, the interferometer, and the scanner are mounted on a common translation stage displaceable towards and away from said object. A dynamic focus solution is provided when the scanner and a folded object path are placed on the translation stage.

Abstract translation: 光学相干断层摄影（OCT）装置包括光源，产生物体光束和参考光束的干涉仪，用于用所述物体光束扫描物体的横向扫描仪，以及用于从OCT信号产生OCT图像的处理器， 所述干涉仪。 至少光源，干涉仪和扫描仪安装在朝向和远离所述物体可移位的公共平移台上。 当扫描仪和折叠对象路径放置在平移台上时，提供动态聚焦解决方案。

公开(公告)号：WO2002059643A2

公开(公告)日：2002-08-01

申请号：PCT/CA2002/000076

申请日：2002-01-23

Applicant: OTI OPHTHALMIC TECHNOLOGIES INC.

Inventor： DUNNE, Shane ,  CHARLES, Steven

IPC: G01S15/89

CPC classification number: G02B26/101 ,  A61B5/0062 ,  A61B5/0064 ,  A61B5/0066 ,  A61B8/4281 ,  A61B8/4461 ,  A61B8/483 ,  B06B1/04 ,  G01S7/521 ,  G01S15/8947 ,  G02B7/1821 ,  G10K11/004 ,  G10K11/355

Abstract: A scanning device, typically ultrasonic, can make a volumetric scan of a conical scanning field. A transducer having a permanent magnet at its back end is gimbal mounted in a housing. Behind the permanent magnet is a hemispheric electromagnet coil assembly having at least two wound electromagnet coils. The coils are energized in turn with an alternating current signal, with the signal applied to any coil being out of phase with the signal applied to any other coil by 180°/n, where n is the number of coils in the hemispheric electromagnet coil assembly. Volumetric scanning is possible by periodically modulating the magnitude or frequency of the signals applied to the coils.

Abstract translation: 扫描装置（通常为超声波）可以对锥形扫描场进行体积扫描。 在其后端具有永磁体的换能器被安装在壳体中。 在永磁体后面是具有至少两个缠绕的电磁体线圈的半球形电磁体线圈组件。 线圈通过交流信号依次通电，施加于任何线圈的信号与施加于任何其他线圈的信号相位相差180°/ n，其中n是半球形电磁线圈组件中线圈的数量 。 通过定期调节施加到线圈的信号的幅度或频率，可以进行体积扫描。

公开(公告)号：WO2009059406A1

公开(公告)日：2009-05-14

申请号：PCT/CA2008/001944

申请日：2008-11-06

Applicant: OTI OPHTHALMIC TECHNOLOGIES INC. ,  HATHAWAY, Mark ,  ROGERS, John A.

Inventor： HATHAWAY, Mark ,  ROGERS, John A.

IPC: G01B11/24 ,  A61B3/10 ,  G01N21/958

CPC classification number: G01B9/02044 ,  A61B3/102 ,  G01B9/02065 ,  G01B9/02091 ,  G01N21/39 ,  G01N21/4795 ,  G01N2021/1787

Abstract: Optical Coherence (OCT) tomography apparatus includes a first interferometer receiving light from a source and having a first and second arms. Light from the first and second arms is combined to produce a first output beam, there being an optical path difference between the first and second arms. A second interferometer in tandem with the first receives as an input the output beam from the first interferometer. The second interferometer has a reference arm and an object arm. Light from the reference and object arms is combined to produce a second output beam, there being an optical path difference between said reference and object arms. The optical path difference in said first interferometer is matched to the optical path difference in the second interferometer to produce an output signal. Alternatively, the object arm can be in the first interferometer.

Abstract translation: 光学相干（OCT）断层摄影装置包括从源极接收光并具有第一和第二臂的第一干涉仪。 来自第一和第二臂的光被组合以产生第一输出光束，在第一和第二臂之间存在光程差。 第一干涉仪与第一干涉仪一起接收来自第一干涉仪的输出光束作为输入。 第二干涉仪具有参考臂和物体臂。 来自参考物体和物体臂的光被组合以产生第二输出光束，所述参考物体和对象臂之间存在光程差。 所述第一干涉仪中的光程差与第二干涉仪中的光程差相匹配以产生输出信号。 或者，物体臂可以在第一干涉仪中。

公开(公告)号：WO2007051293A1

公开(公告)日：2007-05-10

申请号：PCT/CA2006/001782

申请日：2006-10-31

Applicant: OTI OPHTHALMIC TECHNOLOGIES INC. ,  ROGERS, John, A. ,  HATHAWAY, Mark

Inventor： ROGERS, John, A. ,  HATHAWAY, Mark

IPC: A61B6/03 ,  A61B3/10 ,  G01N21/84

CPC classification number: A61B3/102 ,  G01N21/4795

Abstract: A method of performing spectral OCT imaging on a target involves repeatedly scanning said target along a transverse scanning line with an object beam derived from an OCT interferometer having a narrowband source. The wavelength of the narrowband source is modulated over a range of wavelengths at a rate that is slow relative to the rate of scanning the target. The object beam returned from the target is detected to produce a set of data obtained from multiple scans along said scanning line over the entire range of wavelengths. The data is then processed to extract an OCT image (typically a B-scan) of the target containing depth information.

Abstract translation: 在目标上进行光谱OCT成像的方法涉及用具有窄带源的OCT干涉仪衍生的物体光束沿着横向扫描线重复扫描所述目标。 窄带源的波长以相对于扫描目标的速率较慢的速率在波长范围内进行调制。 检测从目标物返回的目标光束，以产生在整个波长范围内沿着扫描线从多次扫描获得的一组数据。 然后处理数据以提取包含深度信息的目标的OCT图像（通常为B扫描）。

公开(公告)号：WO2007051292A1

公开(公告)日：2007-05-10

申请号：PCT/CA2006/001781

申请日：2006-10-31

Applicant: OTI OPHTHALMIC TECHNOLOGIES INC. ,  ROGERS, John, A. ,  HATHAWAY, Mark

Inventor： ROGERS, John, A. ,  HATHAWAY, Mark

IPC: A61B6/03 ,  A61B3/10 ,  G01N21/84 ,  G02B27/22 ,  G03H1/00

CPC classification number: G01N21/4795 ,  A61B3/102

Abstract: In an OCT apparatus, an object light beam is returned from a target and interferes with a reference light beam. Image information is obtained from a depth Z in the target that depends on the optical path difference between the object and reference beams with a resolution that depends on the coherence length of the light. A scanner transversely scans the target with the object beam over a plurality of image points defined by the resolution of the apparatus. Interface optics directs the reference and object beams onto an array of detector elements such that the optical path difference between the reference beam and the object beam varies across the array. The reference beam and the object beam interfere with each other over the array of detector elements for individual image points on the target during each transverse scan. A memory stores a subset of data points corresponding to each individual image point obtained from each detector elements of the array. A processor processes one or more of the subsets of data points to derive image information extending over a range of depths in the target for each individual image point. The obtained image information is displayed on a displace device.

Abstract translation: 在OCT设备中，物体光束从目标返回并干扰参考光束。 图像信息从目标中的深度Z获得，其取决于取决于光的相干长度的分辨率的对象和参考光束之间的光程差。 扫描仪在由装置的分辨率限定的多个图像点上用对象光束横向扫描目标。 接口光学器件将参考光束和物体光束引导到检测器元件的阵列上，使得参考光束和物体光束之间的光程差在阵列上变化。 参考光束和物体光束在每个横向扫描期间在目标上的各个图像点的检测器元件阵列上彼此干涉。 存储器存储对应于从阵列的每个检测器元件获得的每个单独图像点的数据点的子集。 处理器处理数据点的一个或多个子集以导出在每个单独图像点的目标中的深度范围上延伸的图像信息。 获得的图像信息显示在位移装置上。

公开(公告)号：WO2004102112A1

公开(公告)日：2004-11-25

申请号：PCT/CA2004/000730

申请日：2004-05-17

Applicant: OTI OPHTHALMIC TECHNOLOGIES INC. ,  PODOLEANU, Adrian, Gh. ,  JACKSON, David, A. ,  ROGERS, John, A. ,  DOBRE, George, M. ,  CUCU, Radu, G.

Inventor： PODOLEANU, Adrian, Gh. ,  JACKSON, David, A. ,  ROGERS, John, A. ,  DOBRE, George, M. ,  CUCU, Radu, G.

IPC: G01B9/02

CPC classification number: A61B3/102 ,  A61B5/0066 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/0203 ,  G01B9/02058 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/23 ,  G01N21/4795

Abstract: OCT apparatus includes an interferometer, having an input beam splitter and a 50/50 output splitter. The splitting ratio of the input splitter may be optimized depending on the source power of light source and on the mismatch of the balanced receiver. The input splitter is a plate beam-splitter to minimize the stray reflected light in the interferometer and allow sequential operation of the apparatus in the OCT or in the confocal regime. The switching between the two regimes may be at will, or synchronous with the en-face scanning which results in quasi-simultaneous OCT/confocal imaging or in alternatives frames, confocal and OCT. By using polarization sensitive elements, two channels are provided in each regime, OCT and confocal. The two confocal polarization sensitive channels may allow adjustments of compensators prior to OCT measurements or OCT imaging.

Abstract translation: OCT设备包括具有输入分束器和50/50输出分离器的干涉仪。 输入分路器的分频比可以根据光源的功率和平衡接收机的不匹配进行优化。 输入分路器是平板分光器，以最小化干涉仪中的杂散反射光，并允许在OCT或共聚焦状态下对装置的顺序操作。 两种方案之间的切换可以是随意的，或者与进行准同时OCT /共聚焦成像或替代帧，共聚焦和OCT的en-face扫描同步。 通过使用极化敏感元件，在每个方案中提供了两个通道，OCT和共聚焦。 两个共焦极化敏感通道可以允许在OCT测量或OCT成像之前调整补偿器。

公开(公告)号：WO2009073970A1

公开(公告)日：2009-06-18

申请号：PCT/CA2008/002144

申请日：2008-12-10

Applicant: OTI OPHTHALMIC TECHNOLOGIES INC. ,  MCLEAN, Duncan ,  PEDRO, Justin ,  ROGERS, John

Inventor： MCLEAN, Duncan ,  PEDRO, Justin ,  ROGERS, John

IPC: A61B3/024 ,  A61B3/12

CPC classification number: A61B3/024 ,  A61B3/102 ,  A61B3/1225 ,  A61B3/1241

Abstract: A method of performing a retinal examination is described wherein perimetry points are selected in three dimensional imaging data of the retinal tissue. The corresponding points in register with these perimetry points are mapped to an en-face image. These corresponding points are used as stimulus locations for a micro-perimetry examination.

Abstract translation: 描述了进行视网膜检查的方法，其中在视网膜组织的三维成像数据中选择视野图。 将这些周边点注册的对应点映射到面部图像。 这些对应点用作微观测量检查的刺激位置。