公开(公告)号：WO2005116902A3

公开(公告)日：2006-08-17

申请号：PCT/IB2005051645

申请日：2005-05-20

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR ,  PAULUS TIMO

Inventor： PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR ,  PAULUS TIMO

IPC: G06F19/00

CPC classification number: G06F19/321 ,  G16H10/40

Abstract: The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (C p ) of the imaging agent in plasma (301), in metabolites (304, 504) and in blood elements (303) (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (200). This is made possible by deploying an injection function (S INJ (t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.

Abstract translation: 本发明涉及一般的复合隔室模型和隔室分析程序，其非侵入性地提取血浆（301）中的成像剂在代谢物（304,504）中的浓度（C） 在来自在参考组织区域（200）内测量的时间信号曲线的血液元件（303）（如红细胞，血小板，血浆蛋白等）中。 这可以通过部署作为输入的注射功能（SUB）作为输入，其作为时间的函数对施用给患者的成像剂的量进行建模。 本发明允许向医生介绍等离子体输入功能，而不需要侵入性地抽取血液样本。

公开(公告)号：WO2003077365A3

公开(公告)日：2003-09-18

申请号：PCT/IB2003/000746

申请日：2003-02-27

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL & STANDARDS GMBH ,  PURR, Thomas ,  BRAMBILLA, Nora ,  PELIGRAD, Dragos-Nicolae

Inventor： PURR, Thomas ,  BRAMBILLA, Nora ,  PELIGRAD, Dragos-Nicolae

IPC: H01Q9/04

Abstract: A multiband microwave antenna (1) is described, which antenna is intended particularly for surface mounting (SMD) on a printed circuit board (PCB) and has a substrate (10) having at least a first and a second metallization structure (11, 12), wherein the first metallization structure (11) has at least a metal area (111) forming a resonator area and the second metallization structure (12) has at least a resonant printed conductor structure (121), thus enabling the antenna to combine the advantageous properties of a PIFA (planar inverted F-antenna) with those of a PWA (printed wire antenna).

公开(公告)号：WO2011095898A1

公开(公告)日：2011-08-11

申请号：PCT/IB2011/050068

申请日：2011-01-07

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  PELIGRAD, Dragos-Nicolae

Inventor： PELIGRAD, Dragos-Nicolae

IPC: A61B5/055 ,  A61B6/00 ,  G06T7/00

CPC classification number: A61B6/481 ,  A61B6/037 ,  A61B6/469 ,  A61B6/5247 ,  A61B6/583 ,  A61B8/4416 ,  A61B8/481 ,  G06T7/0016 ,  G06T2207/10084 ,  G06T2207/30096

Abstract: A method includes obtaining a first image of first contrast agent uptake in non tissue of interest of a patient. The first image is generated based on data from first data from a first imaging modality. The method further includes obtaining a second image of second contrast agent uptake in tissue of interest and the non tissue of interest of the patient. The second image is generated based on second data from a second different imaging modality. The method further includes generating a first image mask based on the first image and generating a first feature image based on the second image and the first image mask. The method further includes displaying at least the first feature image.

Abstract translation: 一种方法包括获得患者感兴趣的非组织中的第一造影剂摄取的第一图像。 基于来自第一成像模态的第一数据的数据生成第一图像。 该方法还包括获得感兴趣组织和患者感兴趣的非组织中的第二造影剂摄取的第二图像。 基于来自第二种不同成像模式的第二数据生成第二图像。 该方法还包括基于第一图像生成第一图像掩码，并且基于第二图像和第一图像掩模生成第一特征图像。 该方法还包括至少显示第一特征图像。

公开(公告)号：WO2005116902A2

公开(公告)日：2005-12-08

申请号：PCT/IB2005/051645

申请日：2005-05-20

Applicant: PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  PELIGRAD, Dragos-Nicolae ,  SPIES, Lothar ,  PAULUS, Timo

Inventor： PELIGRAD, Dragos-Nicolae ,  SPIES, Lothar ,  PAULUS, Timo

IPC: G06F19/00

CPC classification number: G06F19/321 ,  G06F19/00 ,  G16H10/40

Abstract: The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (C p ) of the imaging agent in plasma (301), in metabolites (304, 504) and in blood elements (303) (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (200). This is made possible by deploying an injection function (S INJ (t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.

Abstract translation: 本发明涉及一般的复合区室模型和隔室分析程序，其非侵入性地提取血浆（301），代谢物（304,504）和血液元件（303）中的成像剂的浓度（Cp）（如 红细胞，血小板，血浆蛋白等）从参考组织区域（200）中测量的时间信号曲线。 这是通过部署注射功能（SINJ（t））作为对作为时间的函数对患者施用的成像剂的量进行建模的输入而实现的。 本发明允许向医生介绍等离子体输入功能，而不需要侵入性地抽取血液样本。

公开(公告)号：WO2005116647A2

公开(公告)日：2005-12-08

申请号：PCT/IB2005051665

申请日：2005-05-23

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR ,  PAULUS TIMO

Inventor： PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR ,  PAULUS TIMO

IPC: G01N33/50 ,  G06F19/00

CPC classification number: G06T7/20 ,  G06F19/321 ,  G06T2207/10072 ,  G06T2207/30004 ,  G16H50/50

Abstract: The invention relates to the estimation of kinetic parameters for a target region (210) utilizing information from a normal (unperturbed) reference region (200). The proposed compartmental model models metabolic pathways for blood, reference and target tissue. The proposed analysis procedure features two alternatives: (A) Extraction of the plasma input in the reference region (200) and its unperturbed kinetic parameters, hereafter utilization of the plasma input and the kinetic parameters of the reference region as initial parameters for the analysis of the target region (210). (B) The system of kinetic equations describing the kinetics of the imaging agent in the target and reference regions is solved for the input function (amount of free imaging agent in the plasma or the total imaging agent SB(t) contained in plasma, blood elements and metabolites) considered to be the same for both regions.

Abstract translation: 本发明涉及利用来自正常（未扰动）参考区域（200）的信息估计目标区域（210）的动力学参数。 提出的区室模型为血液，参考和靶组织建立代谢途径。 提出的分析程序具有两个选择：（A）参考区域（200）中的等离子体输入的提取及其未扰动的动力学参数，以下将等离子体输入的利用和参考区域的动力学参数用作分析的初始参数 目标区域（210）。 （B）解决了描述目标和参考区域中成像剂的动力学的动力学方程的系统，用于输入功能（等离子体中的游离显像剂的量或血浆中的总成像剂SB（t），血液 元素和代谢物）被认为是相同的两个地区。

公开(公告)号：WO2003077365A2

公开(公告)日：2003-09-18

申请号：PCT/IB2003/000746

申请日：2003-02-27

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL & STANDARDS GMBH ,  PURR, Thomas ,  BRAMBILLA, Nora ,  PELIGRAD, Dragos-Nicolae

Inventor： PURR, Thomas ,  BRAMBILLA, Nora ,  PELIGRAD, Dragos-Nicolae

IPC: H01Q9/04

CPC classification number: H01Q13/10 ,  H01Q5/371 ,  H01Q5/378 ,  H01Q9/0407

Abstract: A multiband microwave antenna (1) is described, which antenna is intended particularly for surface mounting (SMD) on a printed circuit board (PCB) and has a substrate (10) having at least a first and a second metallization structure (11, 12), wherein the first metallization structure (11) has at least a metal area (111) forming a resonator area and the second metallization structure (12) has at least a resonant printed conductor structure (121), thus enabling the antenna to combine the advantageous properties of a PIFA (planar inverted F-antenna) with those of a PWA (printed wire antenna).

Abstract translation: 描述了一种多频带微波天线（1），该天线特别地用于印刷电路板（PCB）上的表面安装（SMD），并且具有基板（10），该基板具有至少第一和第二 （11,12），其中所述第一金属化结构（11）具有形成谐振器区域的至少一个金属区域（111），并且所述第二金属化结构（12）具有至少一个谐振印制导体结构（121） ，从而使得天线能够将PIFA（平面倒F型天线）的有利特性与PWA（印刷线型天线）的有利特性相结合。

公开(公告)号：WO2010004464A1

公开(公告)日：2010-01-14

申请号：PCT/IB2009/052679

申请日：2009-06-22

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  PELIGRAD, Dragos-Nicolae

Inventor： PELIGRAD, Dragos-Nicolae

IPC: G01R33/28 ,  G01R33/48

CPC classification number: G01R33/5601 ,  A61K49/18 ,  A61K51/12 ,  G01R33/481

Abstract: Magnetic resonance (MR) imaging typically has excellent spatial resolution, but relatively poor temporal resolution. In contrast, positron emission tomography (PET) typically has excellent temporal resolution, but poor spatial resolution relative to MR. Resultantly, it is advantageous to use combined PET-MR imaging sequences to create hybrid or enhanced images that reap the benefits of both modalities. A contrast agent (80) that includes both a PET tracer (82) and MR contrast enhancement (86) can be used in such a combined modality setting. The contrast agent (80) also includes a targeting system (84) that allows the contrast agent (80) to pool in a region of interest.

Abstract translation: 磁共振（MR）成像通常具有优异的空间分辨率，但相对较差的时间分辨率。 相比之下，正电子发射断层摄影（PET）通常具有优异的时间分辨率，但相对于MR而言空间分辨率差。 因此，有利的是使用组合的PET-MR成像序列来产生混合或增强的图像，从而获得两种模式的益处。 包括PET示踪剂（82）和MR对比度增强（86）的造影剂（80）可以用于这种组合形态设置。 造影剂（80）还包括允许造影剂（80）在感兴趣区域中聚集的靶向系统（84）。

公开(公告)号：WO2005109343A3

公开(公告)日：2006-10-12

申请号：PCT/IB2005051446

申请日：2005-05-03

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  PAULUS TIMO ,  PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR

Inventor： PAULUS TIMO ,  PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR

IPC: G06T7/00 ,  G06F19/00

CPC classification number: G06T7/0012 ,  G06F19/321 ,  G06T2200/04 ,  G06T2207/10104 ,  G06T2207/20092 ,  G06T2207/30004

Abstract: The invention relates to a data processing system (1) for the evaluation of image data, particularly of PET-images (I), that represent the time varying concentration of a tracer substance like F-MISO in an object (20). The data processing system (1) comprises a library module (48) with analytical solutions (C j (t)) for several compartment models. Preferably the library also contains the analytical gradients with respect to the parameters of interest. From the library an appropriate solution for each study can be chosen by a user. The use of analytical functions together with the information about the error (s A ( t )) of the input data (either via noise models 43 or via a simulation 44) allows to extract all parameters mandatory to fully understand the kinetics of complex models (more than one tissue compartment) on a per-voxel basis in a robust way in real-time.

Abstract translation: 本发明涉及一种用于评价特定于PET图像（I）的图像数据的数据处理系统（1），其表示物体（20）中的示踪物质如F-MISO的时变浓度。 数据处理系统（1）包括具有用于几个隔室模型的分析解决方案（C（j））的库模块（48）。 优选地，库还包含关于感兴趣的参数的分析梯度。 从图书馆，每个研究的适当解决方案可由用户选择。 使用分析功能以及关于输入数据的错误（通过噪声模型43或经由模拟44）的错误的信息允许（例如， 提取所有必要的参数，以实时的方式，以健壮的方式充分了解复杂模型（多于一个组织室）的动力学。

公开(公告)号：WO2005116647A3

公开(公告)日：2005-12-08

申请号：PCT/IB2005/051665

申请日：2005-05-23

Applicant: PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  PELIGRAD, Dragos-Nicolae ,  SPIES, Lothar ,  PAULUS, Timo

Inventor： PELIGRAD, Dragos-Nicolae ,  SPIES, Lothar ,  PAULUS, Timo

IPC: G06F19/00

Abstract: The invention relates to the estimation of kinetic parameters for a target region (210) utilizing information from a normal (unperturbed) reference region (200). The proposed compartmental model models metabolic pathways for blood, reference and target tissue. The proposed analysis procedure features two alternatives: (A) Extraction of the plasma input in the reference region (200) and its unperturbed kinetic parameters, hereafter utilization of the plasma input and the kinetic parameters of the reference region as initial parameters for the analysis of the target region (210). (B) The system of kinetic equations describing the kinetics of the imaging agent in the target and reference regions is solved for the input function (amount of free imaging agent in the plasma or the total imaging agent S B (t) contained in plasma, blood elements and metabolites) considered to be the same for both regions.

公开(公告)号：WO2005109343A2

公开(公告)日：2005-11-17

申请号：PCT/IB2005/051446

申请日：2005-05-03

Applicant: PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  PAULUS, Timo ,  PELIGRAD, Dragos-Nicolae ,  SPIES, Lothar

Inventor： PAULUS, Timo ,  PELIGRAD, Dragos-Nicolae ,  SPIES, Lothar

IPC: G06T7/00

CPC classification number: G06T7/0012 ,  G06F19/321 ,  G06T2200/04 ,  G06T2207/10104 ,  G06T2207/20092 ,  G06T2207/30004

Abstract: The invention relates to a data processing system (1) for the evaluation of image data, particularly of PET-images (I), that represent the time varying concentration of a tracer substance like F-MISO in an object (20). The data processing system (1) comprises a library module (48) with analytical solutions (C,(t)) for several compartment models. Preferably the library also contains the analytical gradients with respect to the parameters of interest. From the library an appropriate solution for each study can be chosen by a user. The use of analytical functions together with the information about the error (6 A ( t )) of the input data (either via noise models 43 or via a simulation 44) allows to extract all parameters mandatory to fully understand the kinetics of complex models (more than one tissue compartment) on a per-voxel basis in a robust way in real-time.

Abstract translation: 本发明涉及一种用于评价特定于PET图像（I）的图像数据的数据处理系统（1），其表示物体（20）中的示踪物质如F-MISO的时变浓度。 数据处理系统（1）包括具有用于几个隔室模型的分析解决方案（C，（t））的库模块（48）。 优选地，库还包含关于感兴趣的参数的分析梯度。 从图书馆，每个研究的适当解决方案可由用户选择。 使用分析函数以及关于输入数据的错误（6A（t））的信息（通过噪声模型43或通过模拟44）允许提取强制性的所有参数以完全理解复杂模型的动力学（更多 比一个组织室）以一个健壮的方式实时地在每个体素基础上。