公开(公告)号：WO1995020361A1

公开(公告)日：1995-08-03

申请号：PCT/US1994014378

申请日：1994-12-12

Applicant: PHILADELPHIA HEART INSTITUTE ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： PHILADELPHIA HEART INSTITUTE ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  THE CATHOLIC UNIVERSITY OF AMERICA ,  MARCHLINSKI, Francis, E., M.D. ,  SCHWARTZMAN, David, S. ,  MIROTZNIK, Mark, S. ,  FOSTER, Kenneth, R. ,  GOTTLIEB, Charles, D. ,  CHANG, Isaac

IPC: A61B17/39

CPC classification number: A61N1/025 ,  A61B18/1402 ,  A61B18/1492 ,  A61B2018/00702 ,  A61B2018/00875 ,  A61B2018/126 ,  A61B2034/2051 ,  A61B2090/065 ,  A61N1/05 ,  A61N1/056 ,  A61N1/40

Abstract: A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip (10) of a catheter (14) into the chamber of the beating heart and measuring the impedance of the endocardium at various locations within the beating heart. The values measured are compared to impedance values with a predetermined range of values (22) to identify an infarcted area of myocardium and distinguish such area from normal myocardium (20). The measurements are also compared to a range of values for an infarction border zone. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia. In accordance with the methods of the present invention, the risk of arrhythmia in a beating heart may be substantially reduced or eliminated by ablating endocardium within the infarction border zone utilizing the same catheter tip.

Abstract translation: 在搏动心脏中定位梗塞的心肌组织的方法包括将导管（14）的阻抗测量尖端（10）插入跳动心脏的腔室中并测量心脏跳动心脏内各个位置处的心内膜的阻抗的步骤 。 将所测量的值与具有预定范围值（22）的阻抗值进行比较，以鉴定心肌的梗死面积并将该区域与正常心肌区分开（20）。 也将测量结果与梗塞边界区域的范围进行比较。 梗死边界区是心律失常的重要来源，特别是室性心动过速。 根据本发明的方法，通过利用相同的导管尖端在梗死边界区域中消融心内膜，可以显着减少或消除跳动心脏中的心律不齐的风险。