-
公开(公告)号：JP2003174895A
公开(公告)日：2003-06-24
申请号：JP2002290121
申请日：2002-10-02
Applicant: PROGENITOR INC
Inventor： SNODGRASS RALPH H , CIOFFI JOSEPH , ZUPANCIC THOMAS JOEL , SHAFER ALAN WAYNE
IPC: G01N33/53 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P7/06 , A61P35/00 , C07K14/705 , C07K14/715 , C07K14/72 , C07K16/24 , C07K16/28 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/6883 , C12R1/91 , G01N33/50 , G01N33/566
Abstract: PROBLEM TO BE SOLVED: To provide an isolated polypeptide containing the extracellular domain of a hematopoietin receptor. SOLUTION: The isolated polypeptide containing an amino acid sequence represented by a specific sequence residue. The polypeptide is encoded in a new gene which contains two FN3 domains containing the characteristic [WS box] of a hematopoietin family gene obtained by isolating a cDNA clone from a human fetal liver cDNA library and then determining its DNA sequence. COPYRIGHT: (C)2003,JPO
-
2.发明申请DETECTION OF THE LEPTIN RECEPTOR IN REPRODUCTIVE ORGANS AND METHODS FOR REGULATING REPRODUCTIVE BIOLOGY 审中-公开检测生殖器官中的LEPTIN受体和调节生殖生物学的方法
公开(公告)号：WO1997041263A1
公开(公告)日：1997-11-06
申请号：PCT/US1997007676
申请日：1997-04-28
Applicant: PROGENITOR, INC.
Inventor： PROGENITOR, INC. , SNODGRASS, Ralph, H. , CIOFFI, Joseph , ZUPANCIC, Thomas, J. , SHAFER, Alan, W.
IPC: C12Q01/68
CPC classification number: C07K14/705 , A61K38/00 , C07K14/715 , C07K14/72 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5091
Abstract: The present invention relates to variant forms of the receptor for the obese gene product. In particular, the invention relates to methods of detecting receptor variants in the reproductive organs for the diagnosis of the cause of infertility. In addition, it relates to methods of inhibiting or down-regulating expression of defective variants in cells to augment their responsiveness to regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system to improve fertility.
Abstract translation: 本发明涉及肥胖基因产物的受体的变体形式。 特别地，本发明涉及在生殖器官中检测受体变体以诊断不育原因的方法。 此外，它涉及抑制或降低细胞中缺陷变体表达的方法，以增加其对瘦素调节的反应性以及使用化合物直接激活与该配体 - 受体系统相关的信号转导途径以改善生育力的方法 。
-
3.发明申请DETECTION OF A LEPTIN RECEPTOR VARIANT AND METHODS FOR REGULATING OBESITY 审中-公开检测LEPTIN受体变体和调节肥胖的方法
公开(公告)号：WO1997026523A2
公开(公告)日：1997-07-24
申请号：PCT/US1997000881
申请日：1997-01-17
Applicant: PROGENITOR, INC.
Inventor： PROGENITOR, INC. , SNODGRASS, H., Ralph , CIOFFI, Joseph , ZUPANCIC, Thomas, J. , SHAFER, Alan, W.
IPC: G01N00/00
CPC classification number: G01N33/5041 , A61K38/00 , C07K14/705 , C07K14/715 , C07K14/72 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5091
Abstract: The present invention relates to a variant form of the receptor for the obese gene product. In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals. In addition, it relates to methods of inhibiting or down-regulating expression of this variant in cells to augment their responsiveness to weight regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system.
Abstract translation: 本发明涉及用于肥胖基因产物的受体的变体形式。 特别地，本发明涉及在肥胖个体的细胞和组织中检测该受体变体的方法。 此外，本发明涉及抑制或降低细胞中该变体表达的方法，以增加其对瘦素对体重调节的反应性，以及使用化合物直接激活与该配体 - 受体系统相关的信号转导途径的方法。
-
4.发明专利
公开(公告)号：AU731685C
公开(公告)日：2002-08-22
申请号：AU1831197
申请日：1997-01-21
Applicant: PROGENITOR INC
Inventor： SNODGRASS H RALPH , CIOFFI JOSEPH , ZUPANCIC THOMAS J , SHAFER ALAN W , MIKHAIL ADEL A , BARUT BRUCE A
IPC: C12N15/09 , A61K38/00 , A61K38/22 , A61K48/00 , A61P7/00 , A61P7/06 , A61P9/00 , A61P17/02 , A61P35/00 , A61P37/00 , C07K14/575 , C07K14/715 , C12N5/078 , C12N5/0786 , C12N5/0789 , C12Q1/68 , C12N5/00 , C07H21/00 , C12N15/00 , C12N15/79
-
公开(公告)号：AU2998097A
公开(公告)日：1997-11-19
申请号：AU2998097
申请日：1997-04-28
Applicant: PROGENITOR INC
Inventor： SNODGRASS RALPH H , CIOFFI JOSEPH , ZUPANCIC THOMAS J , SHAFER ALAN W
IPC: G01N33/53 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P7/06 , A61P35/00 , C07K14/705 , C07K14/715 , C07K14/72 , C07K16/24 , C07K16/28 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/50 , G01N33/566 , C12P19/34 , C07H21/02 , C07H21/04
Abstract: The present invention relates to variant forms of the receptor for the obese gene product. In particular, the invention relates to methods of detecting receptor variants in the reproductive organs for the diagnosis of the cause of infertility. In addition, it relates to methods of inhibiting or down-regulating expression of defective variants in cells to augment their responsiveness to regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system to improve fertility.
-
Patent Agency Ranking
公开(公告)号：WO1997026272A1
公开(公告)日：1997-07-24
申请号：PCT/US1997000880
申请日：1997-01-17
Applicant: PROGENITOR, INC.
Inventor： PROGENITOR, INC. , SNODGRASS, H., Ralph , CIOFFI, Joseph , ZUPANCIC, Thomas, J. , SHAFER, Alan, W.
IPC: C07H21/04
CPC classification number: C07K14/705 , A61K38/00 , C07K14/715 , C07K14/72 , C12N2503/02 , C12N2510/00 , C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5091
Abstract: The present invention relates to a variant form of the receptor for the obese gene product. In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals. In addition, it relates to methods of inhibiting or down-regulating expression of this variant in cells to augment their responsiveness to weight regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system.
Abstract translation: 本发明涉及ob产物基因受体的变体，并且特别涉及用于检测肥胖个体的细胞和组织中的所述受体的方法。 本发明还涉及在细胞中抑制或减少这种变体以增加它们对瘦素重量调节作用的反应的方法，以及使用直接激活转导途径的化合物的方法。 与该配体/受体系统相关的信号。
-
公开(公告)号：CA2176463C
公开(公告)日：2006-07-11
申请号：CA2176463
申请日：1995-08-30
Applicant: PROGENITOR INC
Inventor： SNODGRASS H RALPH , CIOFFI JOSEPH , ZUPANCIC THOMAS JOEL , SHAFER ALAN WAYNE
IPC: C12N15/12 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P7/06 , A61P35/00 , C07K14/705 , C07K14/715 , C07K14/72 , C07K16/24 , C07K16/28 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/6883 , C12R1/91 , G01N33/50 , G01N33/566
Abstract: The present invention relates to a novel member of the hematopoietin recepto r family, herein referred to as Hu-B1.219. In particular , the invention relates to nucleotide sequences and expression vectors encodin g Hu-B1.219 gene product. Genetically engineered host ce lls that express the Hu-B1.219 coding sequence may be used to evaluate and scree n for ligands or drugs involved in Hu-B1.219 interaction and regulation. Since Hu-B1.219 expression has been detected in certain huma n fetal tissues and cancer cells, molecular probes desig ned from its nucleotide sequence may be useful for prenatal testing and cancer d iagnosis.
-
公开(公告)号：AU1941899A
公开(公告)日：1999-07-12
申请号：AU1941899
申请日：1998-12-21
Applicant: PROGENITOR INC , UNIV VANDERBILT
Inventor： HIRATA KEN-ICHI , QUERTERMOUS THOMAS , CIOFFI JOSEPH A , ZUPANCIC THOMAS
-
公开(公告)号：CA2268771A1
公开(公告)日：1998-04-09
申请号：CA2268771
申请日：1997-09-30
Applicant: PROGENITOR INC
Inventor： WOLFF ROGER K , RUDDY DAVID A , THOMAS WINSTON J , TSUCHIHASHI ZENTA , LAUER PETER M , KRONMAL GREGORY S , FEDER JOHN N
IPC: C12N15/09 , C07K14/705 , C07K14/74 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , C07H21/04 , C12N15/63 , C12N15/85 , C12P21/02
Abstract: Polymorphic sites in the region surrounding the HFE gene are provided. These polymorphisms are useful as surrogate markers in diagnostic assays for hemochromatosis. Additionally, a fine structure map of the 1 megabase region surrounding the HFE gene is provided, along with 235 kb of DNA sequence and 8 loci corresponding to candidate genes within the 1 megabase region, and in the purification of related proteins.
-
10.发明专利
公开(公告)号：ZA9703703B
公开(公告)日：1998-01-29
申请号：ZA9703703
申请日：1997-04-29
Applicant: PROGENITOR INC
Inventor： SNODGRASS H RALPH , CIOFFI JOSEPH , ZUPANCIC THOMAS J , SHAFER ALAN W
IPC: G01N33/53 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P7/06 , A61P35/00 , C07K14/705 , C07K14/715 , C07K14/72 , C07K16/24 , C07K16/28 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/50 , G01N33/566 , C12N , A61K , G01N
CPC classification number: C07K14/705 , A61K38/00 , C07K14/715 , C07K14/72 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5091
-
-
-
-
-
-
-
-
-
Search Results
43
records
(took 0.018 seconds)
