公开(公告)号：WO2007014188A3

公开(公告)日：2009-04-30

申请号：PCT/US2006028770

申请日：2006-07-25

Applicant: UNIV DUKE ,  WISCONSIN ALUMNI RES FOUND ,  PALMER GREGORY M ,  RAMANUJAM NIMALA

Inventor： PALMER GREGORY M ,  RAMANUJAM NIMALA

IPC: G01N21/00

CPC classification number: G01N21/4738 ,  G01N2021/4742 ,  G01N2021/4752 ,  G01N2201/1296

Abstract: The presently disclosed subject matter provides methods, systems, and computer program products for optimizing a probe geometry for spectroscopic measurement in a turbid medium. A probe geometry comprising one emitting entity for emitting electromagnetic radiation into a turbid medium and at least one collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium is selected. A simulation is performed with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values. The measured optical parameter values are input to an Inversion algorithm to produce corresponding optical properties as output and are compared to reference values. The simulation and inversion steps are repeated and compared for a plurality of additional probe geometries and an optimal geometry is selected.

Abstract translation: 目前公开的主题提供了用于优化用于在混浊介质中进行光谱测量的探针几何形状的方法，系统和计算机程序产品。 选择包括用于将电磁辐射发射到混浊介质中的一个发射实体的探针几何形状和用于收集与混浊介质相互作用的电磁辐射的至少一个收集实体。 使用探针几何的输入和与浑浊介质相关联的多组光学性质值的输入来执行模拟，以产生包括由每组输入光学性质值由探针几何测量的光学参数值的输出。 测量的光学参数值被输入到反转算法，以产生相应的光学性质作为输出并且与参考值进行比较。 重复模拟和反演步骤并对多个附加探针几何进行比较，并选择最佳几何形状。

公开(公告)号：WO2007014188A2

公开(公告)日：2007-02-01

申请号：PCT/US2006/028770

申请日：2006-07-25

Applicant: DUKE UNIVERSITY ,  WISCONSIN ALUMNI RESEARCH FOUNDATION ,  PALMER, Gregory, M. ,  RAMANUJAM, Nimala

Inventor： PALMER, Gregory, M. ,  RAMANUJAM, Nimala

IPC: G01N21/47

CPC classification number: G01N21/4738 ,  G01N2021/4742 ,  G01N2021/4752 ,  G01N2201/1296

Abstract: The presently disclosed subject matter provides methods, systems, and computer program products for optimizing a probe geometry for spectroscopic measurement in a turbid medium. According to one method, a probe geometry comprising one emitting entity for emitting electromagnetic radiation into a turbid medium and at least on collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium is selected. A simulation is performed with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values. The measured optical parameter values are input to an inversion algorithm to produce corresponding optical properties as output. The produced optical properties are compared with optical properties known to correspond to the measured optical parameter values and a degree of matching between the produced optical properties and the known optical properties is determined. The simulation and inversion steps are repeated for a plurality of additional probe geometries. Each additional probe geometry differs from the previously tested probe geometry in at least one property. The property may be a quantity of collecting entities, a diameter of at least one emitting or collecting entity, a linear between the emitting and collecting entities, or combinations thereof. An optimization algorithm is applied at each iteration to select a probe geometry such that the resulting degree of matching will converge to an optimum value. An optimal geometry is selected based on the degree of matching determined for each geometry.

Abstract translation: 目前公开的主题提供了用于优化用于在混浊介质中进行光谱测量的探针几何形状的方法，系统和计算机程序产品。 根据一种方法，选择包括用于将电磁辐射发射到混浊介质中的至少一个发射实体的探针几何形状，并且至少在用于收集与混浊介质相互作用的电磁辐射的收集体上。 使用探针几何的输入和与浑浊介质相关联的多组光学性质值的输入来执行模拟，以产生包括由每组输入光学性质值由探针几何测量的光学参数值的输出。 测量的光学参数值被输入到反演算法中以产生相应的光学特性作为输出。 将所产生的光学性质与已知对应于测量的光学参数值的光学性质进行比较，并且确定所产生的光学性质和已知的光学性质之间的匹配程度。 对于多个额外的探针几何形状，重复模拟和反转步骤。 每个附加的探针几何与至少一个属性中先前测试的探针几何不同。 该属性可以是一定数量的收集实体，至少一个发射或收集实体的直径，发射和收集实体之间的线性，或其组合。 在每个迭代中应用优化算法来选择探针几何，使得所得到的匹配度将会收敛到最佳值。 基于为每个几何确定的匹配程度来选择最佳几何。