PRECISELY-SHAPED POROUS PARTICLES
    4.
    发明申请
    PRECISELY-SHAPED POROUS PARTICLES 审中-公开
    精细形状的多孔颗粒

    公开(公告)号:WO2009085424A1

    公开(公告)日:2009-07-09

    申请号:PCT/US2008/083737

    申请日:2008-11-17

    Abstract: Precisely-shaped composites and methods for making these composites are disclosed. The method of this disclosure comprises introducing a precursor composition onto a production tool having at least one continuous surface and a plurality of cavities so as to fill at least a portion of the cavities with the precursor composition and wherein the precursor composition, upon curing, forms a composition having a shape corresponding to the cavities thereby resulting in a plurality of discrete, precisely-shaped particles having a porosity comprising one of the following: (a) 10 m 2 /g or greater or (b) 5 kdalton or greater. The precisely-shaped particles have at least one essentially flat side. The precisely-shaped particles can be confined in a vessel and used for chromatographic applications.

    Abstract translation: 公开了精确形状的复合材料和制备这些复合材料的方法。 本公开的方法包括将前体组合物引入到具有至少一个连续表面和多个空腔的生产工具上,以便用前体组合物填充至少一部分空腔,并且其中前体组合物在固化时形成 具有与空腔相对应的形状的组合物,从而导致多个离散的精确成形的颗粒,其具有包括以下之一的孔隙率:(a)10m 2 / g或更大或(b)5kdalton或更大。 精确形状的颗粒具有至少一个基本平坦的侧面。 精确形状的颗粒可以限制在容器中并用于色谱应用。

    HYDROPHOBIC MONOMERS, HYDROPHOBICALLY-DERIVATIZED SUPPORTS, AND METHODS OF MAKING AND USING THE SAME
    6.
    发明申请
    HYDROPHOBIC MONOMERS, HYDROPHOBICALLY-DERIVATIZED SUPPORTS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
    疏水性单体,疏水性衍生物的支持物及其制备方法和使用方法

    公开(公告)号:WO2010117598A3

    公开(公告)日:2011-01-13

    申请号:PCT/US2010027978

    申请日:2010-03-19

    Abstract: A composition is disclosed comprising a hydrophobic monomer having the structure:CH2=CR4C(O)NHC(R1R1)(C(R1R1))nC(O)XR3 wherein n is an integer of 0 or 1; R1 is independently selected from at least one of: a hydrogen atom, alkyls, aryls, and alkylaryls, wherein the alkyls, aryls, and alkylaryls have a total of 10 carbon atoms or less; R3 is a hydrophobic group selected from at least one of: alkyls, aryls, alkylaryls and ethers, wherein the alkyls, aryls, alkylaryls and ethers have a total number of carbon atoms ranging from 4 to 30; R4 is H or CH3; X is O or NH. In some embodiments the hydrophobic monomer is derived from an amine or an alcohol (HXR3) that has a hydrophilicity index of 25 or less. A polymerizable composition comprising the hydrophobic monomer is disclosed, which optionally may comprise a cross-linking monomer and/or a non-cross-linking monomer. This polymerizable mixture may be used to from hydrophobically-derivatized supports, which may be used in applications such as hydrophobic interaction chromatography.

    Abstract translation: 公开了一种组合物,其包含具有以下结构的疏水单体:CH 2 = CR 4 C(O)NHC(R 1 R 1)(C(R 1 R1))nC(O)XR 3,其中n为0或1的整数; R 1独立地选自氢原子,烷基,芳基和烷基芳基中的至少一个,其中烷基,芳基和烷基芳基总共具有10个或更少的碳原子; R3是选自烷基,芳基,烷基芳基和醚中的至少一种的疏水基团,其中烷基,芳基,烷基芳基和醚的总碳原子数范围为4-30; R4是H或CH3; X是O或NH。 在一些实施方案中,疏水性单体衍生自亲水性指数为25以下的胺或醇(HXR3)。 公开了包含疏水单体的可聚合组合物,其任选地可以包含交联单体和/或非交联单体。 该可聚合混合物可用于疏水衍生的载体,其可用于例如疏水相互作用层析的应用中。

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