公开(公告)号：WO2002066683A3

公开(公告)日：2002-08-29

申请号：PCT/US2002/003606

申请日：2002-02-06

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  HARPER, James, Douglas ,  MATHEWS, Richard, Hart ,  JOHNSON, Bernadette ,  PETROVICK, Martha, Susan ,  RUNDELL, Ann ,  NARGI, Frances, Ellen ,  STEPHENS, Timothy ,  MENDENHALL, Linda, Marie ,  HOLLIS, Mark, Alexander ,  YOUNG, Albert, M. ,  RIDER, Todd, Holman ,  SCHWOEBEL, Eric, David ,  VIAN, Trina, Rae

Inventor： HARPER, James, Douglas ,  MATHEWS, Richard, Hart ,  JOHNSON, Bernadette ,  PETROVICK, Martha, Susan ,  RUNDELL, Ann ,  NARGI, Frances, Ellen ,  STEPHENS, Timothy ,  MENDENHALL, Linda, Marie ,  HOLLIS, Mark, Alexander ,  YOUNG, Albert, M. ,  RIDER, Todd, Holman ,  SCHWOEBEL, Eric, David ,  VIAN, Trina, Rae

IPC: C12Q1/68

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles (Figure 4). The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

公开(公告)号：WO02066683A2

公开(公告)日：2002-08-29

申请号：PCT/US0203606

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY ,  HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HOLMAN ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HOLMAN ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N21/64 ,  C12M1/34 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58 ,  C12Q1/68 ,  G01N27/26 ,  G01N33/552 ,  G01N33/554 ,  H01L21/203 ,  H01L29/00

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles (Figure 4). The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

Abstract translation: 本发明涉及用于检测一个或多个靶粒子的光电子系统（图4）。 该系统包括反应室，样品收集器，光学检测器和含有细胞的储存器，每个细胞具有存在于每个细胞表面上并且对待检测的靶颗粒是特异性的受体，其中结合 受体的目标颗粒直接或间接激活报告分子，从而产生可测量的光信号。