公开(公告)号：WO1994001093A1

公开(公告)日：1994-01-20

申请号：PCT/US1993006271

申请日：1993-07-01

Applicant: MERCK & CO., INC. ,  RORK, Gerald, S. ,  HASLAM, John, L.

Inventor： MERCK & CO., INC.

IPC: A61K09/24

CPC classification number: A61K9/0004 ,  A61K38/556

Abstract: The instant invention is directed to an osmotic pump, for the controlled release of enalapril to an environment of use, the pump comprising: (A) a core, which comprises a therapeutically effective amount of enalapril, sodium bicarbonate, and lactose surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6.96 x 10-18 to 6.96 x 10-14 cm3 sec/g and a reflection coefficient of less than 0.5, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0.1 to 60 % by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout the wall.

Abstract translation: 本发明涉及渗透泵，用于将依那普利控制释放到使用环境中，所述泵包括：（A）核心，其包含治疗有效量的依那普利，碳酸氢钠和由（B ）控制水不溶性壁的速率，具有6.96×10-18至6.96×10-14厘米3秒/克的流体渗透性和小于0.5的反射系数，由以下物质制备：（i）可渗透水但不渗透的聚合物 溶解和（ii）0.1至60重量％，基于（i）和（ii）的总重量，分散在整个壁上的至少一种pH不敏感的成孔添加剂。

公开(公告)号：WO1996012478A1

公开(公告)日：1996-05-02

申请号：PCT/US1995013693

申请日：1995-10-19

Applicant: MERCK & CO., INC. ,  RORK, Gerald, S. ,  PIPKIN, James, D.

Inventor： MERCK & CO., INC.

IPC: A61K09/24

CPC classification number: A61K9/2027 ,  A61K9/0004 ,  A61K9/2072 ,  A61K31/4422

Abstract: A device for the controlled delivery of a beneficial agent as a gelatinous dispersion consisting of (i) a core which contains a beneficial agent, a polymer which forms microscopic gel beads upon hydration and the core may also contain an agent to modulate the hydration of the polymer; and (ii) an impermeable, insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of the microscopic gel beads.

Abstract translation: 用于作为凝胶状分散体受控输送有益剂的装置，其包含（i）含有有益试剂的核心，在水合时形成微细凝胶珠粒的聚合物和核心，还可含有调节水合作用的试剂 聚合物; 和（ii）不渗透的不溶性涂层，其粘附并包围芯并且包含提供用于微细凝胶珠的水合和释放的区域的孔。

公开(公告)号：SK279964B6

公开(公告)日：1999-06-11

申请号：SK76994

申请日：1992-12-18

Applicant: RORK GERALD S. ,  PIPKIN JAMES D.

Inventor： RORK GERALD S ,  PIPKIN JAMES D

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K31/74 ,  A61K47/32

Abstract: A device for the controlled delivery of a beneficial agent as a gelatinous dispersion consisting of (i) a core which contains a beneficial agent, a polymer which forms gelatinous microscopic particles upon hydration and if desired an agent to modulate the hydration of the polymer; and (ii) an impermeable, insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of a dispersion comprising gelatinous microscopic particles.

公开(公告)号：WO1996019201A1

公开(公告)日：1996-06-27

申请号：PCT/US1995016530

申请日：1995-12-18

Applicant: MERCK & CO., INC. ,  RORK, Gerald, S. ,  PIPKIN, James, D.

Inventor： MERCK & CO., INC.

IPC: A61K09/24

CPC classification number: A61K9/2072 ,  A61K9/2086

Abstract: A device is disclosed for the controlled delivery of a beneficial agent, the device consisting of (i) a core comprising at least two layers, wherein at least one layer comprises a beneficial agent and a polymer which forms microscopic gel beads upon hydration and at least one layer which comprises a polymer which forms microscopic gel beads upon hydration; and (ii) an impermeable, insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of the microscopic gel beads.

Abstract translation: 公开了用于受控输送有益试剂的装置，该装置由（i）包含至少两层的芯组成，其中至少一层包含有益试剂和在水合时形成微细凝胶珠的聚合物，并且至少 一层，其包含在水合时形成微观凝胶珠的聚合物; 和（ii）不渗透的不溶性涂层，其粘附并围绕芯并且包含提供用于微细凝胶珠的水合和释放的区域的孔。