公开(公告)号：SK279435B6

公开(公告)日：1998-11-04

申请号：SK610390

申请日：1990-12-07

Applicant: SCHLINGMANN GERHARD ,  ROSENFELD STUART A.

Inventor： SCHLINGMANN GERHARD ,  ROSENFELD STUART A

IPC: C07D475/04 ,  C12N9/00 ,  C12P17/18 ,  C12P41/00

Abstract: A process for the preparation of optically pure (6R or 6S)-diastereoisomers of 5,6(R or S),7,8-tetrahydrofolic acid derivative or a salt or esters thereof is described, comprising the conversion of the 5,6S,7,8-tetrahydrofolic acid component of a racemic mixture of 5,6,7,8-tetrahydrofolic acid to 10-formyl-5,6S,7,8-tetrahydrofolic acid in the presence of a formyl tetrahydrofolic synthetase, followed by cyclizing, hydrolyzing and derivatizing. The process is also useful to make a desired substantially pure (6R or 6S) enantiomer of a derivative or tetrahydrofolic acid or a salt or ester thereof.