公开(公告)号：WO2006062745A3

公开(公告)日：2007-07-26

申请号：PCT/US2005042522

申请日：2005-11-22

Applicant: 454 LIFE SCIENCES CORP ,  ATTIYA SAID ,  MAKAHIJANI VINOD B ,  LEI MING ,  CHEN YI-JU ,  SIMPSON JOHN ,  ROTH G THOMAS ,  HO CHUN HEEN ,  PENGGUANG YU

Inventor： ATTIYA SAID ,  MAKAHIJANI VINOD B ,  LEI MING ,  CHEN YI-JU ,  SIMPSON JOHN ,  ROTH G THOMAS ,  HO CHUN HEEN ,  PENGGUANG YU

IPC: C12Q1/68 ,  C12M1/34 ,  G01N33/53 ,  G01N33/543

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00353 ,  B01J2219/00414 ,  B01J2219/00423 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01L2200/0668 ,  B01L2300/0819 ,  B01L2400/0487 ,  C12Q1/6869

Abstract: The present invention relates to methods and apparatuses for conducing densely packed, independent chemical reactions in parallel in fluid-permeable arrays. Accordingly, this invention also focuses on the use of such arrays for applications such as DNA sequencing, most preferably pyrophosphate sequencing, and DNA amplification.

Abstract translation: 本发明涉及用于在流体可渗透阵列中并行地进行密集包装的独立化学反应的方法和装置。 因此，本发明还集中于这种阵列用于诸如DNA测序，最优选焦磷酸测序和DNA扩增的应用。

公开(公告)号：WO2002067768A2

公开(公告)日：2002-09-06

申请号：PCT/US2002/005774

申请日：2002-02-28

Applicant: HOME DIAGNOSTICS, INC. ,  PAOLINI, Gregory, P. ,  ROTH, G., Thomas ,  MODZELEWSKI, Brent, E.

Inventor： PAOLINI, Gregory, P. ,  ROTH, G., Thomas ,  MODZELEWSKI, Brent, E.

IPC: A61B

CPC classification number: G01N21/8483

Abstract: A method an apparatus for strip insertion detection in an analytical meter system. The invention allows for individual meter calibration, adaptive thresholding and ambient light correction. Increased performance is economically realized, while providing enhanced meter accuracy in varying light conditions.

Abstract translation: 一种分析仪系统（10）中的带插入检测装置（124）的方法。 本发明允许单独的仪表校准，自适应阈值和环境光校正。 提高性能经济实现，同时在不同的光线条件下提供增强的仪表精度。

公开(公告)号：WO02067768A3

公开(公告)日：2002-10-17

申请号：PCT/US0205774

申请日：2002-02-28

Applicant: HOME DIAGNOSTICS INC ,  PAOLINI GREGORY P ,  ROTH G THOMAS ,  MODZELEWSKI BRENT E

Inventor： PAOLINI GREGORY P ,  ROTH G THOMAS ,  MODZELEWSKI BRENT E

IPC: G01N21/27 ,  G01N21/77 ,  G01N21/78 ,  G01N21/86 ,  G01N21/75

CPC classification number: G01N21/8483

Abstract: A method an apparatus for strip insertion detection(124) in an analytical meter system(10). The invention allows for individual meter calibration, adaptive thresholding and ambient light correction. Increased performance is economically realized, while providing enhanced meter accuracy in varying light conditions.

Abstract translation: 一种用于分析仪表系统（10）中的带插入检测装置（124）的方法。 本发明允许单独的仪表校准，自适应阈值和环境光校正。 经济上实现了更高的性能，同时在各种光照条件下提供了更高的仪表精度。

公开(公告)号：WO2006062745A2

公开(公告)日：2006-06-15

申请号：PCT/US2005/042522

申请日：2005-11-22

Applicant: 454 LIFE SCIENCES ,  ATTIYA, Said ,  MAKAHIJANI, Vinod, B. ,  LEI, Ming ,  CHEN, Yi-Ju ,  SIMPSON, John ,  ROTH, G., Thomas ,  HO, Chun, Heen ,  PENGGUANG, Yu

Inventor： ATTIYA, Said ,  MAKAHIJANI, Vinod, B. ,  LEI, Ming ,  CHEN, Yi-Ju ,  SIMPSON, John ,  ROTH, G., Thomas ,  HO, Chun, Heen ,  PENGGUANG, Yu

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00353 ,  B01J2219/00414 ,  B01J2219/00423 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01L2200/0668 ,  B01L2300/0819 ,  B01L2400/0487 ,  C12Q1/6869

Abstract: The present invention relates to methods and apparatuses for conducing densely packed, independent chemical reactions in parallel in fluid-permeable arrays. Accordingly, this invention also focuses on the use of such arrays for applications such as DNA sequencing, most preferably pyrophosphate sequencing, and DNA amplification.

Abstract translation: 本发明涉及用于在流体可渗透阵列中并行地进行密集包装的独立化学反应的方法和装置。 因此，本发明还集中于这种阵列用于诸如DNA测序，最优选焦磷酸测序和DNA扩增的应用。

公开(公告)号：WO2002070734A1

公开(公告)日：2002-09-12

申请号：PCT/US2002/003415

申请日：2002-02-28

Applicant: HOME DIAGNOSTICS, INC. ,  MODZELEWSKI, Brent, E. ,  GILMOUR, Steven, B. ,  ROTH, G., Thomas ,  BELL, Douglas, E.

Inventor： MODZELEWSKI, Brent, E. ,  GILMOUR, Steven, B. ,  ROTH, G., Thomas ,  BELL, Douglas, E.

IPC: C12Q1/00

CPC classification number: G01N33/54386 ,  G01N21/8483 ,  G06F19/00 ,  Y10T436/144444

Abstract: The present invention provides a method of measuring an analyte, such a glucose in a fluid sample, such as whole blood, by a reflectance reading device (Figure 1). The method includes making periodic intermediate calculations of analyte level and dynamically ascertaining when an analytical reaction has reached an end point. Once stable, the process stops making periodic calculations and reports the final, actual glucose concentration. According to an exemplary embodiment, the method is performed by a reflectance photometer (10) using an analytical test strip (40) containing reagents that react with an analyte of interest in the test fluid. The end point is determined by calculating an intermediate analyte level of the testing element at predetermined intervals and calculating a ratio value corresponding to the (n) th measurement to an (n-5) th measurement. When two consecutive ratio values are less than or equal to a predetermined value, the end point is deemed reached and the final analyte level ascertained.

Abstract translation: 本发明提供了一种通过反射读取装置（图1）测量诸如全血的流体样品中的分析物如葡萄糖的方法。 该方法包括对分析物水平进行周期性中间计算，并动态确定分析反应何时达到终点。 一旦稳定，该过程将停止定期计算并报告最终的实际葡萄糖浓度。 根据示例性实施例，该方法由反射光度计（10）使用分析测试条（40）进行，所述分析测试条（40）含有与测试流体中感兴趣的分析物反应的试剂。 通过以预定的间隔计算测试元件的中间分析物水平并计算对应于第（n）第三测量的比值到第（n-5）测量来确定终点。 当两个连续的比值小于或等于预定值时，认为达到终点并确定最终的分析物水平。