公开(公告)号：EP1761188A1

公开(公告)日：2007-03-14

申请号：EP05755946.0

申请日：2005-06-01

Applicant: MEDTRONIC, INC. ,  Rothstein, Paul T.

Inventor： ROTHSTEIN, Paul, T. ,  DAIGLE, Tom, P. ,  LUTTERMAN, Alison ,  BRISCOE, Roderick, E. ,  FRANCISHELLI, David, E.

IPC: A61B18/14

CPC classification number: A61B18/1442 ,  A61B2017/2945 ,  A61B2018/00065 ,  A61B2018/00363 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/1432

Abstract: Method and apparatus for ablating target tissue adjacent pulmonary veins of a patient. A clamping ablation tool can include an upper arm (12) having an upper neck (24), a link assembly (25), and an upper actuator (18). The link assembly can include a distal electrode and a proximal electrode. The clamping ablation tool includes a lower arm (14) that mates with the upper arm (12). The lower arm (21) can include a lower neck (42), a distal jaw (44), and a lower actuator (46). The distal jaw can include a jaw electrode (48), and the lower actuator (46) can control movement of the distal jaw (44).

公开(公告)号：WO2010123734A2

公开(公告)日：2010-10-28

申请号：PCT/US2010/031074

申请日：2010-04-14

Applicant: MEDTRONIC INC. ,  AHLBERG, Sarah ,  SIMMA, Sara ,  ROTHSTEIN, Paul T. ,  CLEMENTS, Martin ,  JELICH, Damian ,  LASKE, Timothy G. ,  CLAGUE, Cynthia ,  GREEN, Michael ,  IAIZZO, Paul

Inventor： AHLBERG, Sarah ,  SIMMA, Sara ,  ROTHSTEIN, Paul T. ,  CLEMENTS, Martin ,  JELICH, Damian ,  LASKE, Timothy G. ,  CLAGUE, Cynthia ,  GREEN, Michael ,  IAIZZO, Paul

IPC: A61B17/04

CPC classification number: A61B17/0401 ,  A61B2017/00243 ,  A61B2017/00663 ,  A61B2017/00867 ,  A61B2017/0441 ,  A61B2017/0443 ,  A61B2017/0464 ,  A61B2017/1142

Abstract: A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends and an intermediate segment. A flexible tether is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.

Abstract translation: 一种用于在包括身体组织在内的目标位置处关闭开口的方法，包括围绕开口的周边以间隔开的方式将多个自闭合夹子嵌入目标部位。 每个夹子具有相对的夹子端部和中间部分。 柔性系绳联接到嵌入的夹子上以围绕开口周边形成环。 将拉力施加到至少一个环端，从而将开口的周边拉到其上以完全关闭开口。 环路端部被固定以将目标部位保持在关闭状态。 在一些实施方案中，靶位点是心尖心脏组织，并且该方法作为跨顶部进入程序的一部分进行。

公开(公告)号：WO2009120435A1

公开(公告)日：2009-10-01

申请号：PCT/US2009/034859

申请日：2009-02-23

Applicant: MEDTRONIC, INC. ,  FRANCISCHELLI, David E. ,  STEWART, Mark T. ,  CHEEK, Daniel S. ,  ROSS, Brian J. ,  HAMEED, Asif ,  ROTHSTEIN, Paul T. ,  BATCHELOR, Kester J. ,  COLON, William ,  KLEIN, Scott T. ,  CROWE, Douglas A.

Inventor： FRANCISCHELLI, David E. ,  STEWART, Mark T. ,  CHEEK, Daniel S. ,  ROSS, Brian J. ,  HAMEED, Asif ,  ROTHSTEIN, Paul T. ,  BATCHELOR, Kester J. ,  COLON, William ,  KLEIN, Scott T. ,  CROWE, Douglas A.

IPC: A61B18/14 ,  A61N1/37

CPC classification number: A61B18/1402 ,  A61B5/0422 ,  A61B18/1492 ,  A61B2017/00053 ,  A61B2018/00357 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1472 ,  A61N1/06 ,  A61N1/36017

Abstract: A system for ablating tissue and electrically interfacing with a heart including an electrosurgical instrument, an energy source, and a controller. The instrument includes a shaft maintaining first and second electrodes at a distal section. The electrodes are electrically isolated from one another. The controller controls delivery of energy from the energy source, and monitors electrical signals at the electrodes. The controller is programmed to operate in a monopolar mode and a bipolar mode. In the monopolar mode, the first and second electrodes are electrically uncoupled, and energy from the energy source is delivered to the first electrode in performing an ablation procedure. In the bipolar mode, first and second electrodes are electrically coupled and serve as opposite polarity poles to apply energy to a tissue target site, detect electrical signals at a tissue target site, or both.

Abstract translation: 一种用于消融组织并与包括电外科器械，能量源和控制器的心脏电接口的系统。 仪器包括轴，其在远端部分保持第一和第二电极。 电极彼此电隔离。 控制器控制能量从能源的传递，并监测电极处的电信号。 控制器被编程为在单极模式和双极模式下工作。 在单极模式中，第一和第二电极是电耦合的，并且来自能量源的能量在执行消融过程时被传送到第一电极。 在双极模式中，第一和第二电极被电耦合并且用作相反的极性极以将能量施加到组织靶位点，检测组织靶位置处的电信号，或者两者。

公开(公告)号：WO2006060431A1

公开(公告)日：2006-06-08

申请号：PCT/US2005/043200

申请日：2005-11-30

Applicant: MEDTRONIC, INC. ,  BONNER, Matthew, D. ,  ROTHSTEIN, Paul, T. ,  HINIDUMA-LOKUGE, Prasanga, D. ,  KEOGH, James, R. ,  USHER, Raymond, W. ,  JAHNS, Scott, E. ,  CHEN, Victor, T.

Inventor： BONNER, Matthew, D. ,  ROTHSTEIN, Paul, T. ,  HINIDUMA-LOKUGE, Prasanga, D. ,  KEOGH, James, R. ,  USHER, Raymond, W. ,  JAHNS, Scott, E. ,  CHEN, Victor, T.

IPC: A61B17/34

CPC classification number: A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/2926 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M25/0084

Abstract: Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

Abstract translation: 将生物制剂注入组织的装置和方法。 提供了具有细长轴和远端注射头的装置，用于将针驱动到组织中并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以转换成针驱动力。 一些装置提供可控制的针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

公开(公告)号：WO2005120376A3

公开(公告)日：2006-04-27

申请号：PCT/US2005019129

申请日：2005-06-01

Applicant: MEDTRONIC INC ,  CHRISTIAN STEVEN C ,  DAIGLE TOM P ,  ROTHSTEIN PAUL T

Inventor： CHRISTIAN STEVEN C ,  DAIGLE TOM P ,  ROTHSTEIN PAUL T

IPC: A61B18/14

CPC classification number: A61B18/1442 ,  A61B18/1492 ,  A61B2018/00363 ,  A61B2018/00375 ,  A61B2018/00577

Abstract: System, device and method for ablating target tissue adjacent pulmonary veins of a patient through an incision. An ablation device can include a hinge including a cam assembly, a moving arm, a floating jaw, and a lower jaw. Fingers can engage the floating jaw to hold the floating jaw in a first position with respect to the moving arm. Some embodiments of the invention can provide an ablation device including a central support, an upper four-bar linkage coupled to the central support, an upper jaw coupled to the upper linkage, a lower four-bar linkage coupled to the central support, and a lower jaw coupled to the lower linkage. Some embodiments of the invention can provide an ablation device having an upper jaw including a first cannula connection and a lower jaw including a second cannula connection. The system can include a first catheter coupled to the first cannula connection and a second catheter coupled to the second cannula connection. The first and second catheters can be inserted through the incision and can move the upper and lower jaws adjacent the pulmonary veins.

Abstract translation: 用于通过切口消融患者的肺静脉附近的靶组织的系统，装置和方法。 消融装置可以包括铰链，其包括凸轮组件，移动臂，浮动夹爪和下颚。 手指可以接合浮动的颚板将浮动颚部相对于移动臂保持在第一位置。 本发明的一些实施例可以提供消融装置，其包括中央支撑件，联接到中心支撑件的上部四杆连接件，联接到上部连接件的上部钳口，联接到中心支撑件的下部四杆连杆，以及 下颚连接到下连杆。 本发明的一些实施例可以提供一种消融装置，其具有包括第一套管连接的上颚和包括第二插管连接的下颚。 该系统可以包括耦合到第一插管连接的第一导管和耦合到第二插管连接的第二导管。 第一和第二导管可以穿过切口插入并且能够移动邻近肺静脉的上下爪。

公开(公告)号：WO2009132009A1

公开(公告)日：2009-10-29

申请号：PCT/US2009/041261

申请日：2009-04-21

Applicant: MEDTRONIC, INC. ,  AHLBERG, Sarah, E. ,  DAIGLE, Tom, P. ,  FRANCISCHELLI, David, E. ,  PODBELSKI, Adam, A. ,  HAEG, Daniel, C. ,  ROTHSTEIN, Paul, T. ,  RAMBERG, Steve, V. ,  BATCHELOR, Kester, J. ,  CONWAY, Thomas, J.

Inventor： AHLBERG, Sarah, E. ,  DAIGLE, Tom, P. ,  FRANCISCHELLI, David, E. ,  PODBELSKI, Adam, A. ,  HAEG, Daniel, C. ,  ROTHSTEIN, Paul, T. ,  RAMBERG, Steve, V. ,  BATCHELOR, Kester, J. ,  CONWAY, Thomas, J.

IPC: A61B8/14

CPC classification number: A61B18/1492 ,  A61B2018/00065 ,  A61B2018/00113 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00863 ,  A61B2018/1472 ,  A61B2090/064 ,  A61B2218/002 ,  A61B2218/007

Abstract: An ablation device for ablating tissue having an outer wall and an inner wall, approximately parallel and concentric with said outer wall, defining an inner fluid chamber and an outer low pressure chamber. Each of the outer wall and the inner wall have an edge defining an open face of the fluid chamber and the low pressure chamber. An ablative element is contained within the fluid chamber. A source of low pressure is coupled to the low pressure chamber. When the edge of the outer wall and the edge of the inner wall contact a surface, the ablation device is at least partially secured to the surface by low pressure created in the low pressure chamber by the source of low pressure. The fluid chamber is at least partially fluidly isolated from the low pressure chamber when the ablation device is at least partially secured to the surface.

Abstract translation: 一种用于烧蚀组织的消融装置，其具有与所述外壁大致平行并同心的外壁和内壁，限定内部流体室和外部低压室。 外壁和内壁中的每一个具有限定流体室和低压室的敞开面的边缘。 消融元件包含在流体室内。 低压源连接到低压室。 当外壁的边缘和内壁的边缘接触表面时，消融装置通过由低压源产生的低压室中的低压至少部分地固定到表面。 当消融装置至少部分地固定到表面时，流体室至少部分地与低压室流体隔离。

公开(公告)号：WO2005120374A1

公开(公告)日：2005-12-22

申请号：PCT/US2005/019022

申请日：2005-06-01

Applicant: MEDTRONIC, INC. ,  ROTHSTEIN, Paul, T. ,  BRISCOE, Roderick, E. ,  FRANCISCHELLI, David, E. ,  KIM, David, Jin, Sung ,  LUTTERMAN, Alison

Inventor： ROTHSTEIN, Paul, T. ,  BRISCOE, Roderick, E. ,  FRANCISCHELLI, David, E. ,  KIM, David, Jin, Sung ,  LUTTERMAN, Alison

IPC: A61B18/14

CPC classification number: A61B18/1442 ,  A61B2018/00363 ,  A61B2018/00375 ,  A61B2018/00577

Abstract: Method and apparatus for ablating target tissue adjacent pulmonary veins of a patient. The ablation device (30) can include a lower jaw assembly (32) including a proximal jaw (42) having a proximal electrode (50) and a distal jaw (62) having a distal electrode (70), and an upper jaw assembly (90) including an upper jaw (94) having an upper electrode (98). A proximal actuator (54) can be movable between a first position in which the proximal jaw is open and a second position in which the proximal jaw is clamped with respect to the upper jaw. A distal actuator (76) can be movable between a third position in which the distal jaw is open and a fourth position in which the distal jaw is clamped with respect to the upper jaw.

Abstract translation: 用于消融患者的肺静脉附近的靶组织的方法和装置。 消融装置（30）可以包括下钳口组件（32），其包括具有近端电极（50）的近端钳口（42）和具有远端电极（70）的远端钳口（62）和上钳口组件 90），包括具有上电极（98）的上钳口（94）。 近侧致动器（54）可以在其中近侧颚打开的第一位置和相对于上颚夹紧近端颌的第二位置之间移动。 远侧致动器（76）可以在其中远侧钳口打开的第三位置和相对于上钳口夹紧远端钳口的第四位置之间移动。

公开(公告)号：WO2004100800A2

公开(公告)日：2004-11-25

申请号：PCT/US2004/009843

申请日：2004-03-31

Applicant: MEDTRONIC, INC. ,  ROTHSTEIN, Paul, T. ,  PIGNATO, Paul, A. ,  DAIGLE, Thomas, P. ,  GOODMAN, Jack

Inventor： ROTHSTEIN, Paul, T. ,  PIGNATO, Paul, A. ,  DAIGLE, Thomas, P. ,  GOODMAN, Jack

IPC: A61B17/04

CPC classification number: A61B17/06061 ,  A61B17/0483 ,  A61B90/50 ,  A61B2017/0237

Abstract: A device for holding a surgical suture including a base, a guide body, a cam body, a bearing member, and a spring member. The base has a top side, a front edge, and a back edge. The guide body projects from the top side of the base and defines a guide face having an entrance side and an exit side. The entrance side is adjacent the front edge and the exit side is adjacent the back edge. The cam body is pivotally mounted to the top side and forms a toothed surface positioned to selectively secure a surgical suture against the guide face. The spring member is positioned between the cam body and the bearing member, biasing the toothed surface toward the guide face.

Abstract translation: 一种用于保持包括基部，引导体，凸轮体，支承构件和弹簧构件的手术缝合线的装置。 底座具有顶侧，前边缘和后边缘。 引导体从基部的顶侧突出并且限定具有入口侧和出口侧的引导面。 入口侧邻近前缘，出口侧邻近后缘。 凸轮主体枢转地安装到顶侧并形成齿形表面，其被定位成选择性地将外科缝合线固定抵靠引导面。 弹簧构件定位在凸轮本体和轴承构件之间，将齿形表面朝向引导面偏置。

公开(公告)号：WO2011136935A1

公开(公告)日：2011-11-03

申请号：PCT/US2011/032422

申请日：2011-04-14

Applicant: MEDTRONIC INC. ,  ROTHSTEIN, Paul T. ,  QUILL, Jason

Inventor： ROTHSTEIN, Paul T. ,  QUILL, Jason

IPC: A61B17/04

CPC classification number: A61B17/0401 ,  A61B90/39 ,  A61B2017/00243 ,  A61B2017/00783 ,  A61B2017/0409 ,  A61B2017/0443 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61F2/2427

Abstract: A delivery system for percutaneously guiding a repair or replacement device into a desired position relative to a valve within a patient. The delivery system includes a longitudinal support tube having a distal end, a deformable centering loop extending from the distal end of the support tube, at least one stop positioned on the centering loop and spaced from the distal end of the support tube, at least one clip delivery system slideably attached to the centering loop, and a sheath that is longitudinally slideable relative to the support tube, the centering loop, and the at least one clip delivery tube.

Abstract translation: 一种用于将修复或更换装置经皮引导到相对于患者内的阀的期望位置的输送系统。 输送系统包括纵向支撑管，其具有远端，从支撑管的远端延伸的可变形定心环，至少一个止动件，其位于定心环上并与支撑管的远端间隔开，至少一个 夹子传送系统，其可滑动地附接到定心环，以及相对于支撑管，定心环和至少一个夹子输送管可纵向滑动的护套。

公开(公告)号：WO2010132254A1

公开(公告)日：2010-11-18

申请号：PCT/US2010/033719

申请日：2010-05-05

Applicant: MEDTRONIC INC. ,  STEWART, Mark, T. ,  DIAGLE, Tom, P. ,  FRANCISCHELLI, David, E. ,  LIDDICOAT, John, R. ,  ROTHSTEIN, Paul, T.

Inventor： STEWART, Mark, T. ,  DIAGLE, Tom, P. ,  FRANCISCHELLI, David, E. ,  LIDDICOAT, John, R. ,  ROTHSTEIN, Paul, T.

IPC: A61B18/14

CPC classification number: A61B18/1445 ,  A61B1/00087 ,  A61B1/05 ,  A61B1/06 ,  A61B34/20 ,  A61B2017/00057 ,  A61B2017/2945 ,  A61B2018/00107 ,  A61B2018/00142 ,  A61B2018/0022 ,  A61B2018/00375 ,  A61B2018/00982 ,  A61B2018/1432 ,  A61N1/362

Abstract: Device for sub-xiphoid ablation of patient tissue. A sub-xiphoid access clamp has a handle, an elongate neck coupled to the handle and first and second opposing jaws. The first and second opposing jaws have first and second opposing relief segments being generally co-planar and concave with respect to one another to form a void therebetween, and first and second opposing elongate ablation elements positioned along the first and second opposing jaws and distal of the first and second opposing relief segments relative to the handle. The first and second opposing jaws are articulate between a closed position and an open position to admit, at least in part, a second portion of tissue of the patient within the void created by the first and second opposing relief segments while the first portion of tissue is positioned between the first and second ablation elements in the closed position.

Abstract translation: 用于患者组织的亚剑突消融的装置。 副剑杆通道夹具具有手柄，连接到手柄的细长颈部以及第一和第二相对的夹爪。 第一和第二相对的钳口具有第一和第二相对的浮雕段，它们大致共面并相对于彼此凹入以在它们之间形成空隙，并且第一和第二相对的细长消融元件沿着第一和第二相对的夹爪定位， 第一和第二相对的释放段相对于把手。 第一和第二相对的夹爪在关闭位置和打开位置之间铰接，以至少部分地允许患者在由第一和第二相对的浮雕段产生的空隙内的组织的第二部分，同时组织的第一部分 位于第一和第二消融元件之间处于关闭位置。